Behavioral characterization of serotonergic activation in the flatworm Planaria

Behavioural Pharmacology

Volumn 19, Issue 3, 2008, Pages 177-182

  Farrell, Martilias S ^a   Gilmore, Kirsti ^a   Raffa, Robert B ^a   Walker, Ellen A ^a  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

8 OH DPAT; Invertebrates; Locomotor activity; m chlorophenylpiperazine; Planaria; Serotonin receptors; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; DRUG VEHICLE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B AGONIST; SEROTONIN 2C AGONIST; SEROTONIN RECEPTOR;

ARTICLE; BEHAVIOR; DRUG SOLUTION; HYPERKINESIA; LOCOMOTION; NONHUMAN; PLATYHELMINTH; SEROTONINERGIC SYSTEM; TURBELLARIA; VIDEORECORDING; WRITHING TEST;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, ANIMAL; MOTOR ACTIVITY; PIPERAZINES; PLANARIANS; PYRIDINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 43449135330     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e3282fe885e     Document Type: Article

References (24)

1. Adham N, Zgombick JM, Bard J, Branchek TA (1998). Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation. J Pharmacol Exp Ther 287:508-514.
2. Barbas D, DesGroseillers L, Castellucci VF, Carew TJ, Marinesco S (2003). Multiple serotonergic mechanisms contributing to sensitization in aplysia: evidence of diverse serotonin receptor subtypes. Learn Mem 10:373-386.
3. Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL (1993). Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem 268:23422-23426.
4. Barnes NM, Sharp T (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
5. Buttarelli FR, Pontieri FE, Margotta V, Palladini G (2000). Acetylcholine/dopamine interaction in planaria. Comp Biochem Physiol C Toxicol Pharmacol 125:225-231.
6. Buttarelli FR, Pontieri FE, Margotta V, Palladini G (2002). Cannabinoid-induced stimulation of motor activity in planaria through an opioid receptor-mediated mechanism. Prog Neuropsychopharmacol Biol Psychiatry 26:65-68.
7. Carolei A, Margotta V, Palladini G (1975). Proposal of a new model with dopaminergic-cholinergic interactions for neuropharmacological investigations. Neuropsychobiology 1:355-364.
8. Hori T, Abe S, Baba A, Suzuki T, Shiraishi H (2000). Effects of repeated phencyclidine treatment on serotonin transporter in rat brain. Neurosci Lett 280:53-56.
9. Kahn RS, Wetzler S (1991). m-Chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry 30:1139-1166.
10. Kimmel HD, Carlyon WD (1990). Persistent effects of a serotonin depletor (p-chlorophenylalanine) in regenerated planaria (Dugesia dorotocephala). Behav Neurosci 104:127-134.
11. Kobilka KB, Frielle T, Collins S, Yang-Feng T, Kobilka ST, Fnancke U, Lefkowitz JR (1987). An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329:75-79.
12. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB (1997). Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-1322.
13. Passarelli F, Merante A, Pontieri FE, Margotta V, Venturini G, Palladini G (1999). Opioid-dopamine interaction in planaria: a behavioral study. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:51-55.
14. Raffa RB, Desai P (2005). Description and quantification of cocaine withdrawal signs in Planaria. Brain Res 1032:200-202.
15. Raffa RB, Valdez JM (2001). Cocaine withdrawal in Planaria. Eur J Pharmacol 430:143-145.
16. Raffa RB, Holland LJ, Schulingkamp RJ (2001). Quantitative assessment of dopamine D2 antagonist activity using invertebrate (Planaria) locomotion as a functional endpoint. J Pharmacol Toxicol Methods 45:223-226.
17. Saitoh O, Yuruzume E, Watanabe K, Nakata H (1997). Molecular identification of a G protein-coupled receptor family which is expressed in planarians. Gene 195:55-61.
18. Sarnat HB, Netsky MG (2002). When does a ganglion become a brain? Evolutionary origin of the central nervous system. Semin Pediatr Neurol 9:240-253.
19. Sharif NA, Drace CD, Williams GW, Crider JY (2004). Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. J Pharm Pharmacol 56:1267-1274.
20. Togrol BB (1968). The effect of drugs on the general behaviour, regeneration and learning capacity of planarians. J Biol Psychol 10:20-27.
21. Vickers SP, Easton N, Malcolm CS, Allen NH, Porter RH, Bickerdike MJ, Kennett GA (2001). Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists. Pharmacol Biochem Behav 69:643-652.
22. Welsh JH, Williams LD (1970). Monoamine-containing neurons in planaria. J Comp Neurol 138:103-115.
23. Willins DL, Meltzer HY (1997). Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. J Pharmacol Exp Ther 282:699-706.
24. Wood M, Chaubey M, Atkinson P, Thomas DR (2000). Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT(7) receptor. Eur J Pharmacol 396:1-8.