Development and in vitro characterization of canine CD40-Ig

Veterinary Immunology and Immunopathology

Volumn 123, Issue 3-4, 2008, Pages 260-265

  Jochum, Christoph ^a,c   Beste, Mechthild ^a,c   Stone, Diane ^a   Graves, Scott S ^a   Storb, Rainer ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Canine; CD40; Co stimulatory molecule; Fusion protein

Indexed keywords

CANINE CD40 IG; DIMER; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5C8;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG PURIFICATION; FEMALE; GENETIC TRANSFECTION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MASS SPECTROMETRY; MIXED LYMPHOCYTE REACTION; NONHUMAN; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULINS; LYMPHOCYTE CULTURE TEST, MIXED; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEQUENCE ALIGNMENT;

EID: 43449130024     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.02.005     Document Type: Article

References (24)

1. Fanslow W.C., Anderson D.M., Grabstein K.H., Clark E.A., Cosman D., and Armitage R.J. Soluble forms of CD40 inhibit biologic responses of human B cells. J. Immunol. 149 (1992) 655-660
2. Fehr T., and Sykes M. Tolerance induction in clinical transplantation (Review). Transpl. Immunol. 13 (2004) 117-130
3. Guillot C., Guillonneau C., Mathieu P., Gerdes C.A., Menoret S., Braudeau C., Tesson L., Renaudin K., Castro M.G., Lowenstein P.R., and Anegon I. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. J. Immunol. 168 (2002) 1600-1609
4. Hogan W.J., Little M.-T., Zellmer E., Friedetzky A., Diaconescu R., Gisburne S., Lee R., Kuhr C., and Storb R. Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermates. Biol. Blood Marrow Transplant. 9 (2003) 489-495
5. Jin Y.Z., and Xie S.S. Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft. Transplant. Proc. 35 (2003) 3165-3166
6. Jochum C., Beste M., Zellmer E., Graves S.S., and Storb R. CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1-Gy total body irradiation. Biol. Blood Marrow Transplant. 13 (2007) 164-171
7. Kanaya K., Tsuchida Y., Inobe M., Murakami M., Hirose T., Kon S., Kawaguchi S., Wada T., Yamashita T., Ishii S., and Uede T. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation 75 (2003) 275-281
8. Kawai T., Sogawa H., Boskovic S., Abrahamian G., Smith R.N., Wee S.L., Andrews D., Nadazdin O., Koyama I., Sykes M., Winn H.J., Colvin R.B., Sachs D.H., and Cosimi A.B. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am. J. Transplant. 4 (2004) 1391-1398
9. Kirk A.D., Harlan D.M., Armstrong N.N., Davis T.A., Dong Y., Gray G.S., Hong X., Thomas D., Fechner Jr. J.H., and Knechtle S.J. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 8789-8794
10. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
11. Lee E.N., Lee J., Kim E.Y., Park H.J., Chang C.Y., Jung D.Y., Choi S.Y., Lee S.K., Kwon C.H., Joh J.W., and Kim S.J. Tolerance induction through megadose bone marrow transplantation with two-signal blockade. J. Surg. Res. 130 (2006) 102-109
12. Li S., Thanikachalam M., Pang M., Carreno M., Aitouche A., and Pham S.M. Combined host-conditioning with CTLA4-Ig, tacrolimus, anti-lymphocyte serum, and low-dose radiation leads to stable mixed hematopoietic chimerism. Exp. Hematol. 29 (2001) 534-541
13. Masunaga T., Yamashita K., Sakihama H., Hashimoto T., Hua N., Imai A., Inobe M., Miyazaki T., Todo S., and Uede T. Dimeric but not monomeric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function. Transplantation 80 (2005) 1614-1622
14. McLellan A.D., Sorg R.V., Williams L.A., and Hart D.N. Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. Eur. J. Immunol. 26 (1996) 1204-1210
15. Nomura M., Yamashita K., Murakami M., Takehara M., Echizenya H., Sunahara M., Kitagawa N., Fujita M., Furukawa H., Uede T., and Todo S. Induction of donor-specific tolerance by adenovirus-mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 73 (2002) 1403-1410
16. Raff R.F., Deeg H.J., Farewell V.T., DeRose S., and Storb R. The canine major histocompatibility complex. Population study of DLA-D alleles using a panel of homozygous typing cells. Tissue Antigens 21 (1983) 360-373
17. Stamenkovic I., Clark E.A., and Seed B. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8 (1989) 1403-1410
18. Storb R., Yu C., Wagner J.L., Deeg H.J., Nash R.A., Kiem H.-P., Leisenring W., and Shulman H. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood 89 (1997) 3048-3054
19. Storb R., Yu C., Zaucha J.M., Deeg H.J., Georges G., Kiem H.-P., Nash R.A., McSweeney P.A., and Wagner J.L. Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 94 (1999) 2523-2529
20. Wekerle T., Blaha P., Langer F., Schmid M., and Muehlbacher F. Tolerance through bone marrow transplantation with costimulation blockade (Review). Transpl. Immunol. 9 (2002) 125-133
21. Wekerle T., Kurtz J., Ito H., Ronquillo J.V., Dong V., Zhao G., Shaffer J., Sayegh M.H., and Sykes M. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat. Med. 6 (2000) 464-469
22. Wekerle T., Sayegh M.H., Ito H., Hill J., Chandraker A., Pearson D.A., Swenson K.G., Zhao G., and Sykes M. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 68 (1999) 1348-1355
23. Yamashita K., Masunaga T., Yanagida N., Takehara M., Hashimoto T., Kobayashi T., Echizenya H., Hua N., Fujita M., Murakami M., Furukawa H., Uede T., and Todo S. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation 76 (2003) 1089-1096
24. Yin D., Ma L., Zeng H., Shen J., and Chong A.S. Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy. Transplantation 74 (2002) 345-354