Design and optimization of diclofenac sodium controlled release solid dispersions by response surface methodology

Indian Journal of Pharmaceutical Sciences

Volumn 70, Issue 1, 2008, Pages 22-30

  Shivakumar, H ^a   Desai, B ^a   Deshmukh, G ^a  

^a Karnatak Lingayat Education Society   (India)

Author keywords

Coevaporates; Diclofenac sodium; Eudragit RL 100; Eudragit RS 100; Solid dispersions

Indexed keywords

ALCOHOL; DICLOFENAC; EUDRAGIT; EUDRAGIT RS; POLYMER;

ANALYSIS OF VARIANCE; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DESIGN; DRUG FORMULATION; EQUIPMENT; EVAPORATION; FACTORIAL DESIGN; HYDROPHOBICITY; INFRARED SPECTROSCOPY; LINEAR REGRESSION ANALYSIS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MICROCRYSTALLINE SUSPENSION; MOLECULAR DYNAMICS; RESPONSE SURFACE METHOD; SOLID; STATISTICAL SIGNIFICANCE; THERMAL ANALYSIS; X RAY DIFFRACTION;

EID: 43449106483     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.40327     Document Type: Article

References (21)

1. Ford. JL. The current status of solid dispersions. Pharma Acta Helv 1986;61:69-87.
2. Chiou WC, Reigelman S. Pharmaceutical applications of solid dispersions. J Pharm Sci 1971;60:1281-302.
3. El-Fattah A, Salib NN, El-Assik M. A new approach for controlling the release rate of pheniramine aminosalicylate via solid dispersions. Drug Develop Ind Pharm 1984;10:649-66.
4. Hasegawa A, Nakagawa H, Sugimoto L. Bioavailability and stability of nifedipine-enteric coating agent solid dispersion. Chem Pharm Bull 1985;33:388-91.
5. Karnachi AA, De Hon RA, Khan MA. Compression of indomethacin coprecipitates with polymer mixtures: Effect of preparation methodology. Drug Develop Ind Pharm 1995;21:1473-83.
6. 13C solid state NMR to elucidate physical-chemical association in Eudragit RS100 microencapsulated acyl ester of salicylic acid. Eur J Pharm Biopharm 1998;45:9-12.
7. Jenquin MR, Liebowitz SM, Sarabia RE, Mc Ginity JW. Physical and chemical factors influencing the release of drugs from acrylic films. J Pharm Sci 1990;79:811-6.
8. Pignatello R, Ferro M, De Guidi G, Salemi G, Vandelli MA, Guccione S, et al. Preparation, characterization and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS 100 and RL 100. Int J Pharm 2001;218:27-42.
9. Pignatello R, Ferro M, Puglisi G. Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions. AAPS Pharm Sci Tech 2002;3, article 10.
10. Todd PA, Sorkin EM. Diclofenac sodium a reappraisal of its pharmacodynamic and pharmacokinetic purpose and therapeutic efficacy. Drugs 1988;35:244-85.
11. Sweetman SC. Martindale: The complete drug reference. 33rd ed. London (UK): Pharmaceutical Press; 2002.
12. Giunchedi P, Torre ML, Maggi L, Conti B, Conte U. Cellulose acetate trimellitate containing NSAIDs. Drug Develop Ind Pharm 1995;21:315-30.
13. Lewis GA, Mathieu D, Phan Tan Lui R. Pharmaceutical experimental design. New York (NY): Marcel Dekker; 1999.
14. Biju SS, Maria Gerald Rajan NS, Mishra PR. Dual coated erodible microcapsules for modified release of diclofenac sodium. Eur J Pharm Biopharm 2004;58:61-7.
15. Narendra C, Srinath MS, Prakash Rao B. Development of three layered buccal compact containing metoprolol tartrate by statistical optimization technique. Int J Pharm 2005;304:102-14.
16. Aceves JM, Cruz R, Hernandez E. Preparation and characterization of furosemide-eudragit controlled release systems. Int J Pharm 2000;195:45-53.
17. Information sheets (Basic info 1/E), Eudragit® acrylic polymers for controlled release of active ingredients, Rohm Pharma, 1995.
18. Ammar HO, Khalil RM. Preparation and evaluation of sustained release solid dispersions of drugs with eudragit polymers. Drug Develop Ind Pharm 1997;23:1043-54.
19. Christianah MA. Diclofenac sodium. In: Florey K, editors. Analytical profiles of drug substances. vol. 19. New York: Academic Press; 2005. p. 123-44.
20. Singh B, Agarwal R. Design development and optimization of controlled release microcapsules of diltiazem hydrochloride. Indian J Pharm Sci 2002;64:378-85.
21. Rodriguez M, Jose L, Vila-Jato, Dolores T. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J Control Release 1998;55:67-77.