What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?

Molecular Immunology

Volumn 45, Issue 11, 2008, Pages 3264-3267

  Cohn, Melvin ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Alloreactivity; Restrictive recognition; T cell receptor; TCR structure

Indexed keywords

PROTEIN SUBUNIT; T LYMPHOCYTE RECEPTOR;

ARTICLE; GENE FREQUENCY; GENETIC CODE; GENETIC VARIABILITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DOCKING; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RESTRICTION MAPPING;

ALLELES; CODON; HISTOCOMPATIBILITY ANTIGENS; MODELS, IMMUNOLOGICAL; PROTEIN SUBUNITS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IGG;

EID: 43449097191     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.02.016     Document Type: Article

References (18)

1. Acha-Orbea H., Mitchell D.J., Timmermann L., Wraith D.C., Tausch G.S., Waldor M.K., Zamvil S.S., McDevitt H.O., and Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54 (1988) 263-273
2. Cohn M. The Tritope Model of restrictive recognition by the TCR. Trends Immunol. 24 (2003) 127-131
3. Cohn M. Distinguishing the Tritope from the interaction antigen models. Trends Immunol. 25 (2004) 8-9
4. Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells: I what assumptions about structure are needed to explain function?. Mol. Immunol. 42 (2005) 1419-1443
5. Cohn M. On a key postulate of TCR restrictive function: the V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species MHC. Immunology 120 (2007) 140-142
6. Cohn M. An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition. Immunol. Res. 40 (2008) 128-147
7. Cohn M. The Tritope Model for restrictive recognition of antigen by T-cells: II implications for ontogeny. Evolut. Physiol. Mol. Immunol. 45 (2008) 632-652
8. Colf L.A., Bankovich A.J., Hanick N.A., bowerman N.A., Jones L.L., Kranz D.M., and Garcia D.C. How a single T cell receptor recognizes both self and foreign MHC. Cell 129 (2007) 135-146
9. Felix N.J., Donermeyer D.L., Horvath S., Walters J.J., Gross M.I., Suri A., and Allen P.M. Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes. Nature Immunol. 8 (2007) 388-397
10. Feng D., Bond C.J., Ely L.I., Maynard J., and Garcia K.C. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nature Immunol. 8 (2007) 975-983
11. Hong S.-C., Chelouche A., Lin R.-h., Shaywitz D., Braunstein N.S., Glimcher L., Janeway J., and Charles A. An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell 69 (1992) 999-1009
12. Langman R.E., and Cohn M. The standard model of T-cell receptor function: a critical reassessment. Scand. J. Immunol. 49 (1999) 570-577
13. Matzinger P., and Bevan M.J. Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens?. Cell. Immunol. 29 (1977) 1-5
14. Maynard J., Petersson K., Wilson K.H., Adams E.J., Blondelle S.E., Boulanger M.J., Wilson D.B., and Garcia K.C. Structure of an autoimmune T cell receptor complexed with Class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity 22 (2005) 81-92
15. Portoles P., Rojo J.J., and Janeway Jr. C.A. Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same e T-cell receptor. J. Mol. Cell. Immunol. 4 (1989) 129-137
16. Reinherz E.L., Tan K., Tang L., Kern P., Liu J.-h., Xiong Y., Hussey R.E., Smolyar A., Hare B., Zhang R., Joachimiak A.J., Chang H.-C., Wagner G., and Wang J.-h. The crystal structure of a T cell receptor in complex with peptide and MHC Class II. Science 286 (1999) 1913-1921
17. Turner S.J., Cose S.C., and Carbone F.R. TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity. J. Immunol. 157 (1996) 4979-4985
18. Urban J.L., Kumar V., Kono D.H., Gomez C., Horvath S.J., Clayton J., Ando D.G., Sercarz E.E., and Hood L. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54 (1988) 577-592