On a key postulate of T-cell receptor restrictive function: The V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species major histocompatibility complex

Immunology

Volumn 120, Issue 1, 2007, Pages 140-142

  Cohn, Melvin ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

Allogeneic reactivity; Polymorphism of major histocompatibility complex; Restrictive recognition; T cell receptor; V gene segments

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ALLELE; ALLOIMMUNITY; ALPHA CHAIN; BETA CHAIN; DNA POLYMORPHISM; GENE; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; V GENE;

EID: 33845665456     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02501.x     Document Type: Review

References (13)

1. Zinkernagel RM, Doherty PC. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis. Nature 1974; 251:547-8.
2. Matzinger P, Bevan MJ. Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens? Cellular Immunol 1977; 29:1-5.
3. Cohn M, Epstein R. T-cell inhibition of humoral responsiveness. II. Theory on the role of restrictive recognition in immune regulation. Cellular Immunol 1978; 39:125-53.
4. Langman RE. Cell-mediated immunity and the major histocompatability complex. Rev Physiol Biochem Pharmacol 1978; 81:1-37.
5. Cohn M. The T-cell receptor mediating restrictive recognition of antigen. Cell 1983; 33:657-69.
6. Cohn M. Distinguishing the Tritope from the interaction antigen models. Trends Immunol 2004; 25:8-9.
7. Langman RE, Cohn M. The standard model of T-cell receptor function: a critical reassessment. Scand J Immunol 1999; 49:570-7.
8. Cohn M. The Tritope model for restrictive recognition of antigen by T-cells. I. What assumptions about structure are needed to explain function? Mol Immunol 2005; 42:1419-43.
9. Cohn M. The Tritope model of restrictive recognition by the TCR. Trends Immunol 2003; 24:127-31.
10. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, Arden B, Chien Y-H. Ligand recognition by αβ T cell receptors. Annu Rev Immunol 1998; 16:523-44.
11. Garcia KC, Teyton L, Wilson IA. Structural basis of T cell recognition. Annu Rev Immunol 1999; 17:369-97.
12. Cohn M. An alternative to current thinking about positive selection, negative selection and activation of T-cells. Immunology 2004; 111:1-6.
13. Cohn M. On the logic of positive selection. Immunology 2006; 117:452-3.