PDZ proteins and proximal ion transport

Current Opinion in Nephrology and Hypertension

Volumn 13, Issue 5, 2004, Pages 569-574

  Hernando, Nati ^a   Wagner, Carsten A ^a   Gisler, Serge M ^a   Biber, Jürg ^a   Murer, Heini ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

PDZ; Polarity; Proximal tubules; Transporters

Indexed keywords

COTRANSPORTER; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PDZ PROTEIN;

CELL DIVISION; CELL FUNCTION; CELL POLARITY; DISEASE ASSOCIATION; GENE FUNCTION; GENETIC ANALYSIS; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; EPITHELIUM; HUMANS; ION TRANSPORT; KIDNEY TUBULES, PROXIMAL;

EID: 4344715213     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200409000-00014     Document Type: Review

References (48)

1. Nourry C, Grant SGN, Borg JP. PDZ domain proteins: plug and play. Science STKE 2003; 179:re7.
2. Hillier BJ, Christopherson KS, Prehoda KE, et al. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 1999; 284:812-815.
3. Zimmermann P, Meerschaert K, Reekmans G, et al. PIP2-PDZ domain binding controls the association of syntenin with the plasma membrane. Mol Cell 2002; 9:1215-1225.
4. Cao TT, Deacon HW, Reczek D, et al. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta 2-adrenergic receptor. Nature 1999; 401:286-290.
5. Hall RA, Premont RT, Chow et al. The β2-adrenergic receptor interacts with the Na/H-exchanger regulatory factor to control Na/H-exchange. Nature 1998; 392:626-630.
6. Takamiya K, Kostourou V, Adams S, et al. A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet 2004; 36:172-177.
7. Shenolikar S, Voltz JW, Minkoff CM, et al. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci USA 2002; 99:11470-11475.
8. Kocher O, Pal R, Roberts M, et al. Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol 2003; 23:1175-1180.
9. Roh MH, Margolis B. Composition and function of PDZ protein complexes during cell polarization. Am J Physiol Renal Physiol 2003; 285:F377-F387.
10. Wade JB, Liu J, Coleman RA, et al. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. Am J Physiol Cell Physiol 2003; 285:C1494-C1503.
11. Murthy A, Gonzalez-Agosti C, Cordero E, et al. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 1998; 273:1273-1276.
12. Shenolikar S, Minkoff CM, Steplock DA, et al. N-terminal PDZ domain is required for NHERF dimerization. FEBS Lett 2001; 489:233-236.
13. Gisler SM, Stagljar I, Traebert M, et al. Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem 2001; 276:9206-9213.
14. Short DB, Trotter KW, Reczek D, et al. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 1998; 273:19797-19801.
15. Moyer BD, Denton J, Karlson KH, et al. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J Clin Invest 1999; 104:1353-1361.
16. Karim-Jimenez Z, Hernando N, Biber J, Murer H. Molecular determinants for apical expression of the renal type IIa Na+/Pi-cotransporter. Pflugers Arch 2001; 442:782-790.
17. Hernando N, Deliot N, Gisler SM, et al. PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters. Proc Natl Acad Sci USA 2002; 99:11957-11962.
18. -/- as compared with wild-type mice. Furthermore, with both high- and low-phosphate diet, the intensity of NaPi-IIa staining detected subapically is higher in the knockout than in the wild-type group.
19. Swiatecka-Urban A, Duhaime M, Coutermarsh B, et al. PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 2002; 277:40099-40105.
20. Cheng J, Moyer BD, Milewski M, et al. A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem 2002; 277:3520-3529.
21. Neudauer CL, Joberty G, Macara IG. PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10. Biochem Biophys Res Commun 2001; 280:541-547.
22. Kocher O, Comella N, Gilchrist A, et al. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest 1999; 79:1161-1170.
23. Gisler SM, Pribanic S, Bacic D, et al. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int 2003; 64:1733-1745. This is an extensive yeast-two hybrid analysis that identified a large number of proteins that interact with single PDZ domains of PDZK1. These associated proteins can be divided into transporters [NaPi-II, NaPi-I, NHE3, OCT-N1, CFEX (mouse orthologue of human solute carrier family 26), URAT1 (urate transporter 1)], membrane-associated proteins (MAP17) and regulatory factors [NHERF1, DAKAP2 (dual kinase A anchoring protein 2)]. All interacting proteins immunolocalize in proximal tubules.
24. Ikemoto M, Arai H, Feng D, et al. Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I. Proc Natl Acad Sci USA 2000; 97:6538-6543.
25. Harris MJ, Kuwano M, Webb M, Board PG. Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/cMOAT). J Biol Chem 2001; 276:20876-20881.
26. Nies AT, König J, Yunhai C, et al. Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2). Eur J Biochem 2002; 269:1866-1876.
27. Pribanic S, Gisler SM, Bacic D, et al. Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol Renal Physiol 2003; 285:F784-F791.
28. Leonoudakis D, Conti LR, Radeke CM, et al. A multiprotein trafficking complex composed of SAP97, CASK, Veli and Mint1 is associated with inward rectifier Kir2 potassium channels. J Biol Chem 2004; 279:19051-19063. This study demonstrates that a complex containing SAP (synapse-associated protein) 97, CASK, Veli, and Mint1 associates with the C-terminal PDZ-binding domains of Kir2 channels. The authors propose two association models. In one, SAP97 would interact with Kir2 channels and recruit CASK, Veli, and Mint; in the alternative model, Veli would interact with Kir2 channels and and recruit CASK and SAP97.
29. Straight SW, Karnak D, Borg JP, et al. mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus. Am J Physiol Renal Physiol 2000; 278:F464-F475.
30. Warth R. Potassium channels in epithelial transport. Pflügers Arch 2003; 446:505-513.
31. van Hoek AN, Ma T, Yang B, et al. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol 2000; 278: F310-F316.
32. Neely JD, Amiry-Moghaddam M, Ottersen OP, et al. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc Natl Acad Sci USA 2001; 98:14108-14113.
33. Loh NY, Newey SA, Davies KE, Blake DJ. Assembly of multiple dystrobrevin-containing complexes in the kidney. J Cell Sci 2000; 113:2715-2724.
34. Bunn RC, Jensen MA, Reed BC. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell 1999; 10:819-832.
35. Dransfield DT, Bradford AJ, Smith J, et al. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J 1997; 16:35-43.
36. Weinman EJ, Steplock D, Wang Y, Shenolikar S. Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest 1995; 95:2143-2149.
37. Weinman EJ, Steplock D, Shenolikar S. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett 2003; 536:141-144. This study shows that pharmacological activation of PKA by cAMP inhibits NHE3 activity in BBM isolated from wild-type mice, but has no effect on samples from NHERF1-knockout animals. This lack of response is associated with a reduced cAMP-induced phosphorylation of NHE3.
38. Weinman EJ, Evangelista CM, Steplock D, et al. Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. J Biol Chem 2001; 276:42339-42346.
39. Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signaling. Nature 2002; 417:858-861.
40. Traebert M, Volkl H, Biber J, et al. Luminal and contraluminal action of 1-34 and 3-34 PTH peptides on renal type IIa Na-P(i) cotransporter. Am J Physiol Renal Physiol 2000; 278:F792-F798.
41. Lederer ED, Khundmiri SJ, Weinman EJ. Role of NHERF-1 in regulation of the activity of Na-K-ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol 2003; 14:1949-1951.
42. Raghuram V, Hormuth H, Foskett JK. A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions. Proc Natl Acad Sci USA 2003; 100:9620-9625. This paper describes how phosphorylation by PKC of the PDZ2 domain NHERF1 (on Ser-162) decreases the ability of NHERFI to bind CFTR. In addition, a mutation in NHERF1 that mimics phosphorylation (Ser-162 to Asp) decreases CFTR binding and disrupts the ability of NHERF to stimulate CFTR channel activity.
43. Yun CC, Chen Y, Lang F. Glucocorticoid activation of Na+/H+ exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem 2002; 277:7676-7683.
44. Lee-Kwon W, Kawano K, Choi JW, et al. Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. J Biol Chem 2003; 278:16494-16501.
45. Kim JH, Lee-Kwon W, Park JB, et al. Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. J Biol Chem 2002; 277:23714-23724.
46. Gisler SM, Madjdpour C, Bacic D, et al. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int 2003; 64:1746-1754. This paper shows that D-AKAP2, a dual PKA-binding protein, anchors PKA to PDZK1 and to NHERF1.
47. Wang S, Yue H, Derin RB, et al. Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell 2000; 103:169-179.
48. Cowan CA, Yokoyama SN, Bianchi LM, et al. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 2000; 26:417-430.