Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion (Retraction in: Anesthesiology (2010) 112:4 (1056-1057))

Anesthesiology

Volumn 101, Issue 3, 2004, Pages 626-639

  Fechner, Jörg ^a,c   Ihmsen, Harald ^a   Hatterscheid, Dirk ^a   Jeleazcov, Christian ^a   Schiessl, Christine ^a   Vornov, James J ^b   Schwilden, Helmut ^a   Schüttler, Jürgen ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b GUILFORD PHARMACEUTICALS INC   (United States)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAVAN; GPI 15715; PRODRUG; PROPOFOL; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BREATHING RATE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; ELECTROENCEPHALOGRAM; EMULSION; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPNOSIS; HYSTERESIS; INTRAVENOUS ANESTHESIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEDATION;

ADULT; ALGORITHMS; ANESTHETICS, INTRAVENOUS; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; ELECTROENCEPHALOGRAPHY; HEMODYNAMIC PROCESSES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MODELS, STATISTICAL; PRODRUGS; PROPOFOL; SLEEP;

EID: 4344681198     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200409000-00011     Document Type: Article

References (28)

1. Fechner J, Ihmsen H, Hatterscheid D, Schiessl C, Vornov JJ, Burak E, Schwilden H, Schuttler J: Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers. ANESTHESIOLOGY 2003; 99:303-13
2. Albrecht S, Ihmsen H, Suchodolski K, Frenkel C, Schuttler J: Analgo-sedation in intensive care: A quantitative, EEC-based trial with propofol 1% and 2% [in German]. Anaesthesist 1999; 48:794-801
3. Kelbel I, Koch T, Weber A, Schiefer HG, van Ackern K, Neuhof H: Alterations of bacterial clearance induced by propofol. Acta Anaesthesiol Scand 1999; 43:71-6
4. Nakane M, Iwama H: A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate. Br J Anaesth 1999; 83:397-404
5. Doursout MF, Joseph PM, Liang YY, Hartley CJ, Chelly JE: Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilatation in dogs. Br J Anaesth 2002; 89:492-8
6. Ririe DG, Lundell JC, Neville MJ: Direct effects of propofol on myocardial and vascular tissue from mature and immature rats. J Cardiothorac Vasc Anesth 2001; 15:745-9
7. Schuttler J, Schwilden H, Stoeckel H: Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: Etomidate as an example. Eur J Anaesthesiol 1985; 2:133-42
8. Russell D: Intravenous anaesthesia: Manual infusion schemes versus TCI systems. Anaesthesia 1998; 53 Suppl 1:42-5
9. Janzen PR, Hall WJ, Hopkins PM: Setting targets for sedation with a target-controlled propofol infusion. Anaesthesia 2000; 55:666-9
10. Plummer GF: Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987; 421:171-6
11. Holford NH, Sheiner LB: Kinetics of pharmacologic response. Pharmacol Ther 1982; 16:143-66
12. Hughes MA, Glass PS, Jacobs JR: Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. ANESTHESIOLOGY 1992; 76:334-41
13. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, Schwam EM, Siegel JL: Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: Study with intravenous midazolam. J Clin Psychopharmacol 1990; 10:244-51
14. Schywalsky M, Ihmsen H, Tzabazis A, Fecliner J, Burak E, Vornov J. Schwilden H: Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 2003; 20:182-90
15. Dutta S, Ebling WF: Formulation-dependent brain and lung distribution kinetics of propofol in rats. ANESTHESIOLOGY 1998; 89:678-85
16. Dutta S, Ebling WF: Formulation-dependent pharmacokinetics and pharmacodynamics of propofol in rats. J Pharm Pharmacol 1998; 50:37-42
17. Egan TD, Kern SE, Johnson KB, Pace NL: The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): An electroencephalographic and hemodynamic study in a porcine model. Anesth Analg 2003; 97:72-9
18. Gepts E, Camu F, Cockshott ID, Douglas EJ: Disposition of propofol administered as constant rate intravenous infusions in humans. Anesth Analg 1987; 66:1256-63
19. Schuttler J, Stoeckel H, Schwilden H: Pharmacokinetic and pharmacodynamic modelling of propofol ("Diprivan") in volunteers and surgical patients. Postgrad Med J 1985; 61:53-4
20. Schwilden H, Schuttler J, Stoeckel H: Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: Etomidate as an example. Eur J Anaesthesiol 1985; 2:121-31
21. Hering WJ, Ihmsen H, Langer H, Uhrlau C, Dinkel M, Geisslinger G, Schuttler J: Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteers. ANESTHESIOLOGY 1996; 85:1290-9
22. Dingemanse J, Haussler J, Hering W, Ihmsen H, Albrecht S, Zell M, Schwilden H, Schuttler J: Pharmacokinetic-pharmacodynamic modelling of the EEG effects of Ro 48-6791, a new short-acting benzodiazepine, in young and elderly subjects. Br J Anaesth 1997; 79:567-74
23. Forrest FC, Tooley MA, Saunders PR, Prys-Roberts C: Propofol infusion and the suppression of consciousness: The EEG and dose requirements. Br J Anaesth 1994; 72:35-41
24. Kuizenga K, Wierda JM, Kalkman CJ: Biphasic EEG changes in relation to loss of consciousness during induction with thiopental, propofol, etomidate, midazolam or sevoflurane. Br J Anaesth 2001; 86:354-60
25. Schnider TW, Minto CF, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ: The influence of age on propofol pharmacodynamics. ANESTHESIOLOGY 1999; 90:1502-16
26. Billard V, Gambus PL, Chamoun N, Stanski DR, Shafer SL: A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clin Pharmacol Ther 1997; 61:45-58
27. Rampil IJ: A primer for EEG signal processing in anesthesia. ANESTHESIOLOGY 1998; 89:980-1001
28. Luer MS: Fosphenytoin. Neurol Res 1998; 20:178-82