Protective responses in tuberculosis: Induction of genes for interferon-γ and cytotoxicity by Mycobacterium tuberculosis and during human tuberculosis

Scandinavian Journal of Immunology

Volumn 60, Issue 3, 2004, Pages 299-306

  Toossi, Z ^a,b,d   Mayanja Kizza, H ^c   Kanost, A ^a   Edmonds, K ^a   McHugh, M ^a   Hirsch, C ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c MAKERERE UNIVERSITY   (Uganda)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; GRANULYSIN; GRANZYME B; PERFORIN;

ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE INDUCTION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOLOGY; LYMPHOCYTE; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RNA ANALYSIS; SKIN TEST; TUBERCULOSIS;

CYTOTOXICITY, IMMUNOLOGIC; GRANZYMES; HIV INFECTIONS; HUMANS; INTERFERON TYPE II; MYCOBACTERIUM TUBERCULOSIS; RNA, MESSENGER; SERINE ENDOPEPTIDASES; TUBERCULIN; TUBERCULOSIS;

EID: 4344677183     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2004.01478.x     Document Type: Article

References (37)

1. Raviglione MC, Snider DE Jr, Kochi A. Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic. JAMA 1995;273:220-6.
2. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178:2249-54.
3. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993;178:2243-7.
4. Flynn JL, Goldsrein MM, Triebold KJ, Koller B, Bloom BR. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 1992;89:12013-7.
5. Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med 1999;189:1973-80.
6. Cooper AM, Magram J, Ferrante J, Orme IM. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997;186:39-45.
7. Srenger S, Mazzaccaro RJ, Uyemura K et al. Differential effects of cytolytic T cell subsets on intracellular infection. Science 1997; 276:1684-7.
8. Oddo M, Renno T, Attinger A, Bakker T, MacDonald HR, Meylan PR. Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis. J Immunol 1998;160:5448-54.
9. Newporr MJ, Huxley CM, Husron S et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996;335:1941-9.
10. Ottenhoff TH, Kumararatne D, Casanova JL. Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunol Today 1998;19:491-4.
11. Trinchieri G. In: Paul WE, Fathman CG, Metzger H, eds. Annual Review of Immunology. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity, USA: Annual Reviews Inc., 1995, 251-76.
12. Toossi Z. Cytokine circuits in tuberculosis. Infect Agents Dis 1996;5:98-107.
13. Fujiwara H, Okuda Y, Fukukawa T, Tsuyuguchi I. In vitro tuberculin reactivity of lymphocytes from patients with tuberculous pleurisy. Infect Immun 1982;35:402-9.
14. Hirsch CS, Toossi Z, Othieno C et al. Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis 1999; 180:2069-73.
15. Schwander SK, Torres M, Sada E et al. Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis. J Infect Dis 1998;178: 1434-45.
16. Ribeiro-Rodrigues R, Resende Co T, Johnson JL et al. Sputum cytokine levels in patients with pulmonary tuberculosis as early markets of mycobacterial clearance. Clin Diagn Lab Immunol 2002;9:818-23.
17. Ting LM, Kim AC, Cattamanchi A, Ernst JD. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol 1999;163:3898-906.
18. Hirsch CS, Ellner JJ, Russell DG, Rich EA. Complement receptor-mediated uptake and tumor necrosis factor-alpha-mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages. J Immunol 1994;152:743-53.
19. Mayanja-Kizza H, Wajja A, Wu M et al. Activation of beta-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis. J Infect Dis 2001;183:1801-4.
20. Hartel C, Bein G, Kirchner H, Kluter H. A human whole-blood assay for analysis of T-cell function by quantification of cytokine mRNA. Scand J Immunol 1999;49:649-54.
21. Nathan C, Xie QW. Nitric oxide synthases: toles, tolls, and controls. Cell 1994;78:915-8.
22. MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997;15:323-50.
23. Cooper AM, Adams LB, Dalton DK, Appelberg R, Ehlers S. IFN-gamma and NO in mycobacterial disease: new jobs for old hands. Trends Microbiol 2002;10:221-6.
24. Hoft DF, Worku S, Kampmann B et al. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity. J Infect Dis 2002;186: 1448-57.
25. Bonecini-Almeida MG, Chitale S, Boutsikakis I et al. Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes. J Immunol 1998;160:4490-9.
26. Hirsch CS, Yoneda T, Averill L, Ellnet JJ, Toossi Z. Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-beta 1. J Infect Dis 1994;170:1229-37.
27. Moreira AL, Tsenova L, Murray PJ et al. Aerosol infection of mice with recombinant BCG secreting murine IFN-gamma partially reconstitutes local protective immunity. Microb Pathog 2000;29:175-85.
28. Manca C, Tsenova L, Barry CE III et al. Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates. J Immunol 1999;162:6740-6.
29. Hitsch CS, Hussain R, Toossi Z, Dawood G, Shahid F, Ellnet JJ. Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production. Proc Natl Acad Sci USA 1996;93:3193-8.
30. Aubert-Pivert EM, Chedevergne FM, Lopez-Ramirez GM et al. Cytokine transcripts in pediatric tuberculosis: a study with bronchoalveolar cells. Tuber Lung Dis 2000;80:249-58.
31. Aung H, Toossi Z, McKenna SM et al. Expression of transforming growth factor-beta but not tumor necrosis factor-alpha, interferon-gamma, and interleukin-4 in granulomatous lung lesions in tuberculosis. Tuber Lung Dis 2000;80:61-7.
32. Hirsch CS, Toossi Z, Johnson JL et al. Augmentation of apoptosis and interferon-gamma production at sites of active Mycobacterium tuberculosis infection in human tuberculosis. J Infect Dis 2001;183:779-88.
33. Condos R, Rom WN, Schluget NW. Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol. Lancet 1997;349:1513-5.
34. Mayanja-Kizza H, Johnson JL, Hirsch CS et al. Macrophage-activating cytokines in human immununodeficiency virus type 1-infected and -uninfected patients with pulmonary tuberculosis. J Infect Dis 2001;183:1805-9.
35. Kori M, Barak V, Leibovitz E, Altman Y, Eliraz A, Handzel ZT. Specific in vitro proliferative immune responses and lymphokine production in Ethiopian children with and without tuberculosis. Infection 2000;28:42-5.
36. Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH. CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perform and Fas/Fas ligand-independent mechanism. J Immunol 2001;167:2734-42.
37. Gansert JL, Kiessler V, Engele M et al. Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol 2003; 170:3154-61.