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Volumn 1690, Issue 1, 2004, Pages 42-53

Left ventricular mitogen activated protein kinase signaling following polymicrobial sepsis during streptozotocin-induced hyperglycemia

Author keywords

Diabetes; Endothelin 1; Left ventricular end diastolic pressure; Nitric oxide synthase; Signaling; SIRS

Indexed keywords

ENDOTHELIN 1; GLUCOSE; HEAT SHOCK PROTEIN 27; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; WATER;

EID: 4344668354     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.05.001     Document Type: Article
Times cited : (13)

References (52)
  • 1
    • 0025057128 scopus 로고
    • Handicaps to host defense: Effects of hyperglycemia on C3 and Candida albicans
    • Hostetter M.K. Handicaps to host defense: effects of hyperglycemia on C3 and Candida albicans. Diabetes. 39:1990;271-275
    • (1990) Diabetes , vol.39 , pp. 271-275
    • Hostetter, M.K.1
  • 5
    • 0242582455 scopus 로고    scopus 로고
    • Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation
    • Clark R.J., McDonough P.M., Swanson E., Trost S.U., Suzuki M., Fukuda M., Dillmann W.H. Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation. J. Biol. Chem. 278:2003;44230-44237
    • (2003) J. Biol. Chem. , vol.278 , pp. 44230-44237
    • Clark, R.J.1    McDonough, P.M.2    Swanson, E.3    Trost, S.U.4    Suzuki, M.5    Fukuda, M.6    Dillmann, W.H.7
  • 7
    • 0039486310 scopus 로고    scopus 로고
    • Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties
    • Ren J., Ren B.H., Sharma A.C. Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties. Shock. 18:2002;285-288
    • (2002) Shock , vol.18 , pp. 285-288
    • Ren, J.1    Ren, B.H.2    Sharma, A.C.3
  • 8
    • 0036686075 scopus 로고    scopus 로고
    • Mechanism of immune dysfunction in sepsis: Inducible nitric oxide-meditated alterations in p38 MAPK activation
    • Song G.Y., Chung C.S., Jarrar D., Cioffi W.G., Ayala A. Mechanism of immune dysfunction in sepsis: inducible nitric oxide-meditated alterations in p38 MAPK activation. J. Trauma. 53:2002;276-282
    • (2002) J. Trauma , vol.53 , pp. 276-282
    • Song, G.Y.1    Chung, C.S.2    Jarrar, D.3    Cioffi, W.G.4    Ayala, A.5
  • 9
    • 0030907294 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions
    • Haneda M., Araki S., Togawa M., Sugimoto T., Isono M., Kikkawa R. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes. 46:1997;847-853
    • (1997) Diabetes , vol.46 , pp. 847-853
    • Haneda, M.1    Araki, S.2    Togawa, M.3    Sugimoto, T.4    Isono, M.5    Kikkawa, R.6
  • 10
    • 0142026209 scopus 로고    scopus 로고
    • P38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S., Boehm J., Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat. Rev., Drug Discov. 2:2003;717-726
    • (2003) Nat. Rev., Drug Discov. , vol.2 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 11
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:2001;807-869
    • (2001) Physiol. Rev. , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 12
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • Guha M., Mackman N. LPS induction of gene expression in human monocytes. Cell Signal. 13:2001;85-94
    • (2001) Cell Signal. , vol.13 , pp. 85-94
    • Guha, M.1    MacKman, N.2
  • 13
    • 0032572534 scopus 로고    scopus 로고
    • Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
    • Clerk A., Michael A., Sugden P.H. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? J. Cell Biol. 142:1998;523-535
    • (1998) J. Cell Biol. , vol.142 , pp. 523-535
    • Clerk, A.1    Michael, A.2    Sugden, P.H.3
  • 14
    • 0034822322 scopus 로고    scopus 로고
    • Distinct involvement of NF-κB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal
    • Liu W., Kato M., Itoigawa M., Murakami H., Yajima M., Wu J., Ishikawa N., Nakashima I. Distinct involvement of NF-κB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal. J. Cell. Biochem. 83:2001;271-280
    • (2001) J. Cell. Biochem. , vol.83 , pp. 271-280
    • Liu, W.1    Kato, M.2    Itoigawa, M.3    Murakami, H.4    Yajima, M.5    Wu, J.6    Ishikawa, N.7    Nakashima, I.8
  • 16
    • 0031779828 scopus 로고    scopus 로고
    • Diabetic patients produce an increase in coronary sinus endothelin-1 after coronary artery bypass grafting
    • Fogelson B.G., Nawas S.I., Vigneswaran W.T., Ferguson J.L., Law W.R., Sharma A.C. Diabetic patients produce an increase in coronary sinus endothelin-1 after coronary artery bypass grafting. Diabetes. 47:1998;1161-1163
    • (1998) Diabetes , vol.47 , pp. 1161-1163
    • Fogelson, B.G.1    Nawas, S.I.2    Vigneswaran, W.T.3    Ferguson, J.L.4    Law, W.R.5    Sharma, A.C.6
  • 17
    • 0027381832 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
    • Johnstone M.T., Creager S.J., Scales K.M., Cusco J.A., Lee B.K., Creager M.A. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 88:1993;2510-2516
    • (1993) Circulation , vol.88 , pp. 2510-2516
    • Johnstone, M.T.1    Creager, S.J.2    Scales, K.M.3    Cusco, J.A.4    Lee, B.K.5    Creager, M.A.6
  • 18
    • 0030007350 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Williams S.B., Cusco J.A., Roddy M.A., Johnstone M.T., Creager M.A. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J. Am. Coll. Cardiol. 27:1996;567-574
    • (1996) J. Am. Coll. Cardiol. , vol.27 , pp. 567-574
    • Williams, S.B.1    Cusco, J.A.2    Roddy, M.A.3    Johnstone, M.T.4    Creager, M.A.5
  • 21
    • 0035098023 scopus 로고    scopus 로고
    • Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats
    • Kobayashi T., Kamata K. Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats. Atherosclerosis. 155:2001;313-320
    • (2001) Atherosclerosis , vol.155 , pp. 313-320
    • Kobayashi, T.1    Kamata, K.2
  • 22
    • 0036512582 scopus 로고    scopus 로고
    • Induction of peritoneal sepsis increases the susceptibility of isolated hearts to a calcium paradox-mediated injury
    • Omachi A., Sharma C., Alden K.J., Sam A.D., Ferguson J.L. Induction of peritoneal sepsis increases the susceptibility of isolated hearts to a calcium paradox-mediated injury. Shock. 17:2002;193-198
    • (2002) Shock , vol.17 , pp. 193-198
    • Omachi, A.1    Sharma, C.2    Alden, K.J.3    Sam, A.D.4    Ferguson, J.L.5
  • 23
    • 2142737545 scopus 로고    scopus 로고
    • Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia
    • Gupta A., Sharma A.C. Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia. Shock. 20:2003;375-381
    • (2003) Shock , vol.20 , pp. 375-381
    • Gupta, A.1    Sharma, A.C.2
  • 25
    • 0018546929 scopus 로고
    • Effect of fasting and streptozotocin diabetes insulin binding and action in the isolated mouse soleus muscle
    • Le-Marchand-Brustel Y., Freychet P. Effect of fasting and streptozotocin diabetes insulin binding and action in the isolated mouse soleus muscle. J. Clin. Invest. 64:1979;1505-1515
    • (1979) J. Clin. Invest. , vol.64 , pp. 1505-1515
    • Le-Marchand-Brustel, Y.1    Freychet, P.2
  • 26
    • 0029863131 scopus 로고    scopus 로고
    • N-Monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets
    • Bedoya F.J., Solano F., Lucas M. N-Monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets. Experientia. 52:1996;344-347
    • (1996) Experientia , vol.52 , pp. 344-347
    • Bedoya, F.J.1    Solano, F.2    Lucas, M.3
  • 27
    • 0017199138 scopus 로고
    • Hyperlipoproteinemia in streptozotocin-treated rats
    • Bar-On H., Roheim P.S., Eder H.E. Hyperlipoproteinemia in streptozotocin-treated rats. Diabetes. 25:1976;509-515
    • (1976) Diabetes , vol.25 , pp. 509-515
    • Bar-On, H.1    Roheim, P.S.2    Eder, H.E.3
  • 28
    • 0032148267 scopus 로고    scopus 로고
    • Selective ETA receptor blockade prevents left ventricular remodeling and deterioration of cardiac function in experimental heart failure
    • Mulder P., Richard V., Bouchart F., Derumeaux G., Munter K., Thuillez C. Selective ETA receptor blockade prevents left ventricular remodeling and deterioration of cardiac function in experimental heart failure. Cardiovasc. Res. 39:1998;600-608
    • (1998) Cardiovasc. Res. , vol.39 , pp. 600-608
    • Mulder, P.1    Richard, V.2    Bouchart, F.3    Derumeaux, G.4    Munter, K.5    Thuillez, C.6
  • 29
    • 4344671446 scopus 로고    scopus 로고
    • Effect of endothelin-1 (ET-1) precursor (big ET-1) on sepsis-induced left ventricular and diastolic pressure (LVEDP) and tau along with inducible nitric oxide synthase expression
    • Brahmbhatt S., Gupta A., Sharma A.C. Effect of endothelin-1 (ET-1) precursor (big ET-1) on sepsis-induced left ventricular and diastolic pressure (LVEDP) and tau along with inducible nitric oxide synthase expression. FASEB J. 18:2004;A591
    • (2004) FASEB J. , vol.18 , pp. 591
    • Brahmbhatt, S.1    Gupta, A.2    Sharma, A.C.3
  • 30
    • 0035933432 scopus 로고    scopus 로고
    • Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model
    • Mihm M.J., Seifert J.L., Coyle C.M., Bauyer J.A. Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model. Life Sci. 69:2001;527-542
    • (2001) Life Sci. , vol.69 , pp. 527-542
    • Mihm, M.J.1    Seifert, J.L.2    Coyle, C.M.3    Bauyer, J.A.4
  • 31
    • 0025949931 scopus 로고
    • Cardiovascular sequelae of endotoxin shock in diabetic dogs
    • Law W.R., Moriarty M.T., McLane M.P. Cardiovascular sequelae of endotoxin shock in diabetic dogs. Diabetolgia. 34:1991;687-694
    • (1991) Diabetolgia , vol.34 , pp. 687-694
    • Law, W.R.1    Moriarty, M.T.2    McLane, M.P.3
  • 32
    • 0037454716 scopus 로고    scopus 로고
    • Augmented lipopolysaccharide-induction of the histamine-forming enzyme in streptozotocin-induced diabetic mice
    • Oguri S., Motegi K., Endo Y. Augmented lipopolysaccharide-induction of the histamine-forming enzyme in streptozotocin-induced diabetic mice. Biochim. Biophys. Acta. 1637:2003;83-90
    • (2003) Biochim. Biophys. Acta , vol.1637 , pp. 83-90
    • Oguri, S.1    Motegi, K.2    Endo, Y.3
  • 34
    • 0018964280 scopus 로고
    • Sepsis and septic shock - A review of laboratory models and a proposal
    • Wichterman K.A., Baue A.E., Chaudry I.H. Sepsis and septic shock - a review of laboratory models and a proposal. J. Surg. Res. 29:1980;189-201
    • (1980) J. Surg. Res. , vol.29 , pp. 189-201
    • Wichterman, K.A.1    Baue, A.E.2    Chaudry, I.H.3
  • 35
    • 0030011909 scopus 로고    scopus 로고
    • Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and what we do not know about cytokine regulation
    • Bone R.C. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and what we do not know about cytokine regulation. Crit. Care Med. 24:1996;163-172
    • (1996) Crit. Care Med. , vol.24 , pp. 163-172
    • Bone, R.C.1
  • 36
    • 0031912321 scopus 로고    scopus 로고
    • Elevated plasma endothelin-1 level in streptozotocin-induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin-1
    • Makino A., Kamata K. Elevated plasma endothelin-1 level in streptozotocin-induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin-1. Br. J. Pharmacol. 123:1998;1065-1072
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 1065-1072
    • Makino, A.1    Kamata, K.2
  • 37
    • 0025850342 scopus 로고
    • Endothelin-like immunoreactivity in rat models of diabetes mellitus
    • Takahashi K., Suda K., Lam H.C., Ghatei M.A., Bloom S.R. Endothelin-like immunoreactivity in rat models of diabetes mellitus. J. Endocrinol. 130:1991;123-127
    • (1991) J. Endocrinol. , vol.130 , pp. 123-127
    • Takahashi, K.1    Suda, K.2    Lam, H.C.3    Ghatei, M.A.4    Bloom, S.R.5
  • 38
    • 0029085129 scopus 로고
    • Decrease of renal endothelin 1 content and gene expression in diabetic rats with 4-wk hyperglycemia
    • Shin S.J., Lee Y.J., Lin S.R., Tan M.S., Lai Y.H., Tsai J.H. Decrease of renal endothelin 1 content and gene expression in diabetic rats with 4-wk hyperglycemia. Nephron. 70:1995;486-493
    • (1995) Nephron , vol.70 , pp. 486-493
    • Shin, S.J.1    Lee, Y.J.2    Lin, S.R.3    Tan, M.S.4    Lai, Y.H.5    Tsai, J.H.6
  • 39
    • 0027214427 scopus 로고
    • Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro
    • Suzuki T., Kumazaki T., Mitsui Y. Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro. Biochem. Biophys. Res. Commun. 191:1993;823-830
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 823-830
    • Suzuki, T.1    Kumazaki, T.2    Mitsui, Y.3
  • 40
    • 0027204707 scopus 로고
    • In addition to von Willebrand factor and urinary albumin excretion, plasma endothelin is an indicator of endothelial dysfunction in diabetes mellitus
    • Vermes I., Spooren P.F., Kalsbeek-Batenburg E.M., Haanen C. In addition to von Willebrand factor and urinary albumin excretion, plasma endothelin is an indicator of endothelial dysfunction in diabetes mellitus. Diabetologia. 36:1993;472-473
    • (1993) Diabetologia , vol.36 , pp. 472-473
    • Vermes, I.1    Spooren, P.F.2    Kalsbeek-Batenburg, E.M.3    Haanen, C.4
  • 41
    • 0025100874 scopus 로고
    • Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide
    • Boulanger C., Luscher T.F. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J. Clin. Invest. 85:1990;587-590
    • (1990) J. Clin. Invest. , vol.85 , pp. 587-590
    • Boulanger, C.1    Luscher, T.F.2
  • 42
    • 4344642416 scopus 로고    scopus 로고
    • Upregulated myocardial and renal inducible nitric oxide synthase and preproET-1 during diabetes following sepsis
    • Sharma A.C., Chen H., Gupta A. Upregulated myocardial and renal inducible nitric oxide synthase and preproET-1 during diabetes following sepsis. FASEB J. 17:2003;A642
    • (2003) FASEB J. , vol.17 , pp. 642
    • Sharma, A.C.1    Chen, H.2    Gupta, A.3
  • 43
    • 0037390942 scopus 로고    scopus 로고
    • Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice
    • Chauhan S.D., Seggara G., Vo P.A., Macallister R.J., Hobbs A.J., Ahluwalia A. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J. 17:2003;773-775
    • (2003) FASEB J. , vol.17 , pp. 773-775
    • Chauhan, S.D.1    Seggara, G.2    Vo, P.A.3    MacAllister, R.J.4    Hobbs, A.J.5    Ahluwalia, A.6
  • 44
    • 4344567527 scopus 로고    scopus 로고
    • Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases
    • (in press)
    • Gupta A., Sharma A.C. Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases. Mol. Cell. Biochem. 2003;. (in press)
    • (2003) Mol. Cell. Biochem.
    • Gupta, A.1    Sharma, A.C.2
  • 45
    • 0033867239 scopus 로고    scopus 로고
    • Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression
    • Ding Y., Vaziri N.D., Coulson R., Kamanna V.S., Roh D.D. Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. Am. J. Physiol., Endocrinol. Metab. 279:2000;E11-E17
    • (2000) Am. J. Physiol., Endocrinol. Metab. , vol.279
    • Ding, Y.1    Vaziri, N.D.2    Coulson, R.3    Kamanna, V.S.4    Roh, D.D.5
  • 46
    • 0029958768 scopus 로고    scopus 로고
    • High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase
    • Mancusi G., Hutter C., Baumgartner-Parzer S., Schmidt K., Schutz W., Sexl V. High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase. Biochem. J. 315:1996;281-287
    • (1996) Biochem. J. , vol.315 , pp. 281-287
    • Mancusi, G.1    Hutter, C.2    Baumgartner-Parzer, S.3    Schmidt, K.4    Schutz, W.5    Sexl, V.6
  • 47
    • 0030837996 scopus 로고    scopus 로고
    • High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
    • Cosentino F., Hishikawa K., Katusic Z.S., Luscher T.F. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 96:1997;25-28
    • (1997) Circulation , vol.96 , pp. 25-28
    • Cosentino, F.1    Hishikawa, K.2    Katusic, Z.S.3    Luscher, T.F.4
  • 48
    • 0027299798 scopus 로고
    • Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells
    • Hirata Y., Emori T., Eguchi S., Kanno K., Imai T., Ohta K., Marumo F. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest. 91:1993;1367-1373
    • (1993) J. Clin. Invest. , vol.91 , pp. 1367-1373
    • Hirata, Y.1    Emori, T.2    Eguchi, S.3    Kanno, K.4    Imai, T.5    Ohta, K.6    Marumo, F.7
  • 50
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T., Nebreda A.R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1994;1027-1037
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 51
    • 0032617299 scopus 로고    scopus 로고
    • Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/p44 and p38 MAPK signaling pathways in cardiac myocytes
    • LaPointe M.C., Isenovic E. Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/p44 and p38 MAPK signaling pathways in cardiac myocytes. Hypertension. 33:1999;276-282
    • (1999) Hypertension , vol.33 , pp. 276-282
    • Lapointe, M.C.1    Isenovic, E.2


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