Effects of odorants on the hypothalamic-pituitary-adrenal axis and interleukin-6 (IL-6) and IL-6 receptor mRNA expression in rat hypothalamus after restraint stress

Chemical Senses

Volumn 28, Issue 9, 2003, Pages 767-771

  Komori, Teruhisa ^a   Miyahara, Satoru ^a   Yamamoto, Masato ^a   Matsumoto, Takuya ^a   Zhang, Kai ^a   Nakagawa, Masanori ^a   Nomura, Sen ^a   Motomura, Eishi ^a   Shiroyama, Takashi ^a   Okazaki, Yuji ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ACTH; Brain cytokines; Citralva; Corticosterone; Dimethoxymethylbenzene; Reverse transcriptase polymerase chain reaction

Indexed keywords

BENZENE DERIVATIVE; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; CITRALVA; NITRILE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; GENE AMPLIFICATION; GENE EXPRESSION; GENE SEQUENCE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; IN VITRO STUDY; MALE; NONHUMAN; OLFACTORY RECEPTOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; ANIMAL; DRUG EFFECT; EXERCISE; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; STRESS; WISTAR RAT;

ANIMALS; BENZENE DERIVATIVES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERLEUKIN-6; MALE; NITRILES; PITUITARY-ADRENAL SYSTEM; RATS; RATS, WISTAR; RECEPTORS, INTERLEUKIN-6; RESTRAINT, PHYSICAL; RNA, MESSENGER; STRESS;

EID: 4344655311     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/bjg069     Document Type: Article

References (33)

1. Armario, A. and Castellanos, A. (1984) A simple procedure for direct corticosterone radioimmunoassay in the rat. Rev. Esp. Fisol., 40, 437-443.
2. Arzt, E., Pereda, M.P., Castro, C.P., Pagotto, U., Renner, U. and Stalla, G.K. (1999) Pathophysiological role of the cytokine network in the anterior pituitary gland. Front. Neuroendocrinol., 20, 71-95.
3. Bethin, K.E., Vogt, S.K. and Muglia, L.J. (2000) Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. Proc. Natl Acad. Sci. USA, 97, 9317-9322.
4. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
5. Denda, M., Tsuchiya, T., Shoji, K. and Tanida, M. (2000) Odorant inhalation affects skin barrier homeostasis in mice and humans. Br. J. Dermatol., 142, 1007-1010.
6. Fukata, J., Usui, T., Naitoh, Y., Makai, Y. and Imura, H. (1989) Effects of recombinant human interleukin-1 alpha, -1 beta, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumor cell line AtT-20. J. Endocrinol. 122, 33-39.
7. Fujiwara, R., Komori, T., Noda, Y., Kuraoka, T., Shibata, H., Shizuya, K., Miyahara, S., Ohmori, M., Nomura, J. and Yokoyama, M.M. (1998) Effects of a long-term inhalation of fragrances on the stress-induced immunosuppression in mice. Neuroimmunomodulation, 5, 318-322.
8. Gadient, R.A. and Otten, U.H. (1997) Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials. Prog. Neurobiol., 52, 379-390.
9. Glowinski, J. and Iversen, L.L. (1966) Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J. Neurochem., 13, 655-669.
10. Groul, D.L. and Nelson, T.E. (1997) Physiological and pathological roles of interleukin-6 in the central nervous system. Mol. Neurobiol., 15, 307-339.
11. Hama, T., Miyamoto, M., Tsukui, H., Nishio, C. and Hatanaka, H. (1989) Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett., 104, 340-344.
12. Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Takei, N. and Hatanaka, H. (1991) Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience, 40, 445-452.
13. Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., Nakajima, K., Pyun, K.H. and Kishimoto, T. (1985) Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc. Natl Acad. Sci. USA, 85, 5490-5494.
14. Jacobson, L., Muglia, L.J., Weninger, S.C., Pac, K. and Majzoub, J.A. (2000) CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors. Neuroendocrinology, 71, 79-87.
15. Lyson, K. and McCann, S.M. (1992) Involvement of arachidonic acid cascade pathways in interleukin-6-stimulated corticotropin-releasing factor release in vitro. Neuroendocrinology, 55, 708-713.
16. Minami, M., Kuraishi, Y. and Satoh, M. (1991) Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Biochem. Biophys. Res. Commun., 176, 593-598.
17. Miyahara, S., Komori, T., Fujiwara, R., Shizuya, K., Yamamoto, M., Ohmori, M. and Okazaki, Y. (2000) Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat hypothalamus and midbrain. Life Sci., 66, PL93-PL98.
18. Naitoh, Y., Fukata, J., Tominaga, T., Nakai, Y., Tamai, S., Mori, K. and Imura, H. (1988) Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely moving rats. Biochem. Biophys. Res. Commun., 155, 1459-1463.
19. Nakajima, A., Yamada, K., Zou, L.-B., Yan, Y., Mizuno, M. and Nabeshima, T. (2002) Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels. Free Radic. Biol. Med., 32, 1324-1332.
20. Navarra, P., Tsagarakis, S., Faria, M.S., Rees, L.H., Besser, G.M. and Grossman, A.B. (1991) Interleukin-1 and -6 stimulate the release of corticotrophin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology, 128, 37-44.
21. Ray, D. and Melmed, S. (1997) Pituitary cytokine and growth factor expression and action. Endocr. Rev., 18, 206-228.
22. Sei, Y., Vitkovic, L. and Yokoyama, M.M. (1995) Cytokines in the central nervous system regulatory roles in neuronal function, cell death and repair. Neuroimmunomodulation, 2, 121-133.
23. Shibata, H., Fujiwara, R., Iwamoto, M., Matsuoka, H. and Yokoyama, M.M. (1990) Recovery of PFC in mice exposed to high pressure stress by olfactory stimulation with fragrance. Int. J. Neurosci., 51, 245-247.
24. Shibata, H., Fujiwara, R., Iwamoto, M., Matsuoka, H. and Yokoyama, M.M. (1991) Immunological and behavioral effects of fragrances in mice. Int. J. Neurosci., 57, 151-159.
25. Shizuya, K., Komori, T., Fujiwara, R., Miyahara, S., Ohmori, M. and Nomura, J. (1997) The influence of restraint stress on the expression of mRNAs for IL-6 and the IL-6 receptor in the hypothalamus and midbrain of the rat. Life Sci., 61, PL135-PL140.
26. Shizuya, K., Komori, T., Fujiwara, R., Miyahara, S., Ohmori, M. and Nomura, J. (1998) The expressions of mRNAs for interleukin-6 (IL-6) and the IL-6 receptor (IL-6R) in the rat hypothalamus and midbrain during restraint stress. Life Sci., 62, 2315-2320.
27. Sullivan, K.M. (1995) Polymerase chain rection. In Kendrew, J. (ed.), The Encyclopedia of Molecular Biology. Blackwell O, Oxford, pp.864-867.
28. Szafarczyk, A., Ixart, G., Malaval, F., Nouguier-Soule, J. and Assenmacher, I. (1979) Effects of lesions of the suprachiasmatic nuclei and of p-chlorophenylalanine on the circadian rhythms of adrenocorticotropic hormone and corticosterone in the plasma, and on locomotor activity of rats. J. Endocrinol., 83, 1-16.
29. Tominaga, T., Fukata, J., Naito Y., Usui, T., Murakami, N., Fukushima, M., Nakai, Y., Hirai, Y. and Imura, H. (1991) Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins. Endocrinology, 128, 526-531.
30. Umegaki, H., Yamada, K., Naito, M., Kametama, T., Iguchi, A. and Nabeshima, T. (1996) Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophate. Biochem. Pharmacol., 52, 911-916.
31. Vallières, L. and Rivest, S. (11999) Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia. Endocrinology, 140, 3890-3903.
32. Yamada, M. and Hatanaka, H. (11994) Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res., 643, 173-180.
33. Yamada, K., Umegaki, H., Mezawa, I., Iguchi, A., Kameyama, T. and Nabeshima, T. (1997) Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells. Brain Res. Bull., 43, 573-577.