CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors

Neuroendocrinology

Volumn 71, Issue 2, 2000, Pages 79-87

  Jacobson, Lauren ^a   Muglia, Louis J ^a   Weninger, Stacie C ^a,b   Pacák, Karel ^c,d   Majzoub, Joseph A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Adrenal steroids; Catecholamines; Corticotropin; Corticotropin releasing hormone; Hypoglycemia; Hypovolemia; Interleukins; Stress

Indexed keywords

ADRENALIN; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; INTERLEUKIN 6;

ADRENALIN RELEASE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE DEFICIENCY; HORMONE RESPONSE; HYPOGLYCEMIA; HYPOPHYSIS ADRENAL SYSTEM; HYPOVOLEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS;

EID: 0033976697     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054524     Document Type: Article

References (43)

1. Gann DS, Dallman MF, Engeland WC: Reflex control and modulation of ACTH and corticosteroids. Int Rev Physiol 1981;24:157-199.
2. Plotsky PM: Hypophyseotropic regulation of adenohypophyseal adrenocorticotropin secretion. Fed Proc 1985;44:207-213.
3. Whitnall MH: Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog Neurobiol 1993;40:573-629.
4. Sawchenko PE, Brown ER, Chan RK, Ericsson A, Li HY, Roland BL, Kovacs KJ: The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog Brain Res 1996;107: 201-222.
5. Dallman MF, Strack AM, Akana SF, Bradbury MJ, Hanson ES, Scribner KA, Smith M: Feast and famine: Critical role of glucocorticoids with insulin in daily energy flow; in Martini L, Ganong WF (eds): Frontiers in Neuroendocrinology. New York, Raven Press, 1993, vol 14, pp 303-347.
6. Plotsky PM, Owens MJ, Nemeroff CB: Psychoneuroendocrinology of depression. Psychiatr Clin North Am 1998;21:293-307.
7. Harbuz MS, Chalmers J, DeSouza L, Lightman SL: Stress-induced activation of CRH and c-fos mRNAs in the paraventricular nucleus are not affected by serotonin depletion. Brain Res 1993;609:167-173.
8. Tilders FJ, Schmidt ED, deGoij DC: Phenotypic plasticity of CRF neurons during stress. Ann NY Acad Sci 1993;697:39-52.
9. Plotsky PM, Thrivikraman KV, Meaney MJ: Central and feedback regulation of hypothalamic corticotropin-releasing factor secretion; in Vale WW (eds): CIBA Foundation Symposium. Chichester, Wiley, 1993, vol 172, pp 59-75.
10. Harbuz MS, Conde GL, Marti O, Lightman SL, Jessop DS: The hypothalamic-pituitary-adrenal axis in autoimmunity. Ann NY Acad Sci 1997;823:214-224.
11. Suda T, Tozawa F, Yamada M, Ushiyama T, Tomori N, Sumitomo T, Nakagami Y, Demura H, Shizume K: Insulin-induced hypoglycemia increases corticotropin-releasing factor messenger ribonucleic acid levels in rat hypothalamus. Endocrinology 1988;123:1371-1375.
12. Darlington DN, Barraclough CH, Gann DS: Hypotensive hemorrhage elevates corticotropin-releasing hormone messenger ribonucleic acid (mRNA) but not vasopressin mRNA in rat hypothalamus. Endocrinology 1992;130:1281-1288.
13. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W: Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Science 1995;378:287-292.
14. Muglia L, Jacobson L, Dikkes P, Majzoub JA: Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995;373:427-432.
15. Muglia LJ, Jacobson L, Weninger SC, Luedke CE, Bae DS, Jeong K-H, Majzoub JA: Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in CRH-deficient mice. J Clin Invest 1997;99:2923-2929.
16. Jeong K-H, Jacobson L, Widmaier EP, Majzoub JA: Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. Endocrinology 1999;140:1702-1708.
17. Jacobson L: Glucocorticoid replacement, but not CRH deficiency, prevents adrenalectomy-induced anorexia in mice. Endocrinology 1999; 140:310-317.
18. Schreyer SA, Chua SC, LeBoeuf RC: Obesity and diabetes in TNF-α receptor-deficient mice. J Clin Invest 1998;102:402-411.
19. Daneva T, Spinedi E, Hadid R, Gaillard RC: Impaired hypothalamo-pituitary-adrenal axis function in Swiss nude athymic mice. Neuroendocrinology 1995;62:79-86.
20. Jacobson L, Pacák K: Repeated restraint enhances the plasma norepinephrine, but not the plasma ACTH, corticosterone or epinephrine responses to hemorrhage stress in CRH-deficient male mice. Program of the 80th Annual Meeting of the Endocrine Society, New Orleans, 1998, p 205.
21. Pacák K, Palkovits M, Kvetnansky R, Matern P. Hart C, Kopin IJ, Goldstein DS: Catecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious rats. Endocrinology 1995;136:4814-4819.
22. Zhou D, Kusnecov AW, Shurin MR, DePaoli M, Rabin BS: Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 1993;133:2523-2530.
23. Turnbull AV, Rivier CL: Mechanisms of hypothalamic-pituitary-adrenal axis stimulation by immune signals in the rat. Ann NY Acad Sci 1998;840:434-443.
24. Turnbull AV, Smith GW, Lee S, Vale WW, Lee K-F, Rivier C: CRH type 1 receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. Endocrinology 1999;140:1013-1017.
25. Ando T, Rivier J, Yanaihara H, Arimura A: Peripheral corticotropin-releasing factor mediates the elevation of plasma 1L-6 by immobilization stress in rats. Am J Physiol 1998;275: R1461-R1467.
26. Romero LM, Sapolsky RM: Patterns of adrenocorticotropin secretagogue release with hypoglycemia, novelty, and restraint after colchicine blockade of axonal transport. Endocrinology 1992;132:199-204.
27. Berkenbosch F, DeGoeij DCE, Tilders FJH: Hypoglycemia enhances turnover of corticotropin-releasing factor and of vasopressin in the zona externa of the rat median eminence. Endocrinology 1989;125:28-34.
28. Herman JP: In situ hybridization analysis of vasopressin gene transcription in the paraventricular and supraoptic nuclei of the rat: Regulation by stress and glucocorticoids. J Comp Neurol 1995;363:15-27.
29. Ma XM, Levy A, Lightman SL: Rapid changes in heterunuclear RNA for corticotropin-releasing hormone and arginine vasopressin in response to acute stress. J Endocrinol 1997;152: 81-89.
30. Jeong K-H, Pacák K, Jacobson L, Widmaier EP, Majzoub JA: Delayed plasma catecholamine response to restraint stress in corticotropin-releasing hormone-deficient mice. Program of the 79th Annual Meeting of the Endocrine Society, Minneapolis, 1997, p 98.
31. Smith GW, Aubry J-M, Dellu F, Contarino A, Bilezikian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee K-F: Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 1998;20:1093-1102.
32. Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N: Regulation of ACTH secretion: Variations on a theme of B. Recent Prog Horm Res 1987;43:113-173.
33. Jacobson L, Sapolsky RM: Augmented ACTH responses to stress in adrenalectomized rats replaced with constant, physiological levels of corticosterone are partially normalized by acute increases in corticosterone. Neuroendocrinology 1993;58:420-429.
34. Keller-Wood ME, Shinsako J, Dallman MF: Integral as well as proportional adrenal responses to ACTH. Am J Physiol 1983;245: R53-R59.
35. Jasper MS, Engeland WC: Splanchnicotomy increases adrenal sensitivity to ACTH in non-stressed rats. Am J Physiol 1997;273:E363-E368.
36. Schulte HM, Chrousos GP, Gold PW, Booth JD, Oldfield EH, Cutler GB, Loriaux DL: Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications. J Clin Invest 1985;75:1781-1785.
37. Levin N, Shinsako J, Dallman MF: Corticosterone acts on the brain to inhibit adrenalectomy-induced adrenocorticotropin secretion. Endocrinology 1988;122:694-701.
38. Dallman MF, Makara CB, Roberts JL, Levin N, Blum M: Corticotrope response to removal of releasing factors and corticosteroids in vivo. Endocrinology 1985;117:2190-2197.
39. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JMHM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W: Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 1998;19:162-166.
40. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW: Cloning and characterization of human urocortin. Endocrinology 1996;137:2167-2170.
41. Dietrick KD, Lehnert H, DeSouza EB: Corticotropin-releasing factor receptors: An overview. Exp Clin Endocrinol Diabetes 1997;105:65-83.
42. Karalis K, Muglia LJ, Bae D, Hilderbrand H, Majzoub JA: CRH and the immune system. J Neuroimmunol 1997;72:131-136.
43. Manfredi B, Sacerdote P, Gaspani L, Poli V, Panerai AE: IL-6 knock-out mice show modified basal immune functions, but normal immune responses to stress. Brain Behav Immun 1998;12:201-211.