Development of a chromatographic bioreactor based on immobilized β-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 5, 2004, Pages 1179-1189

  Calleri, E ^a   Marrubini, G ^a   Massolini, G ^a   Lubda, D ^b   De Fazio, S S ^a   Furlanetto, S ^c   Wainer, I W ^d   Manzo, L ^a   Caccialanza, G ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b MERCK KGAA   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Glucuronidase; Cytochrome P 450 2D6; Dextromethorphan; Dextrorphan; Immobilized enzyme reactor

Indexed keywords

8 QUINOLINOL DERIVATIVE; BETA GLUCURONIDASE; CYTOCHROME P450; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; GLUCURONIDE; ISOPROTEIN;

ARTICLE; BIOREACTOR; CATALYSIS; CHROMATOGRAPHY; DRUG DETERMINATION; DRUG URINE LEVEL; ENZYME IMMOBILIZATION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMOBILIZED ENZYME REACTOR; METABOLIC ACTIVATION; PRIORITY JOURNAL; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; DEXTRORPHAN; ENZYMES, IMMOBILIZED; GLUCURONIDASE; HUMANS; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 4344652819     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.02.033     Document Type: Article

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