Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CY11B2

European Journal of Endocrinology

Volumn 151, Issue 1, 2004, Pages 73-85

  Enberg, Ulla ^a   Volpe, Cristina ^a   Höög, Anders ^a   Wedell, Anna ^a   Farnebo, Lars Ove ^a   Thorén, Marja ^a   Hamberger, Bertil ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANTIHYPERTENSIVE AGENT; HYDROCORTISONE; MESSENGER RNA; PARAFFIN; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE;

ADOLESCENT; ADRENAL CORTEX ADENOMA; ADRENAL GLAND; ADRENAL HYPERPLASIA; ADRENALECTOMY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE CLASSIFICATION; ENDOCRINE SYSTEM EXAMINATION; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE LOCATION; GENETIC CODE; HISTOPATHOLOGY; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NUCLEOTIDE SEQUENCE; POSTOPERATIVE PERIOD; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STEROIDOGENESIS; TREATMENT OUTCOME; TUMOR RECURRENCE; ZONA GLOMERULOSA;

ADENOMA; ADOLESCENT; ADRENAL GLAND NEOPLASMS; ADRENALECTOMY; ADULT; AGED; ALDOSTERONE SYNTHASE; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERALDOSTERONISM; HYPERPLASIA; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; RETROSPECTIVE STUDIES; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; TREATMENT OUTCOME;

EID: 4344634801     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1510073     Document Type: Article

References (25)

1. Conn JW. Painting background Part II. Primary aldosteronism, a new clinical syndrome. Journal of Laboratory and Clinical Medicine 1955 45 6-17.
2. Pascoe L, Curnow KM, Slutsker L, Connell JM, Speiser PW, New MI & White PC. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. PNAS 1992 89 8327-8331.
3. Lifton RP, Dluhy RG, Powers M, Ulick S & Lalouel JM. The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension. Transactions of the Association of American Physicians. 1992 105 64-71.
4. Lafferty AR, Torpy DJ, Stowasser M, Taymans SE, Lin JP, Huggard P, Gardon RD & Stratakis CA. A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). Journal of Medical Genetics 2000 37 831-835.
5. Mornet E, Dupont J, Vitek A & White PC. Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta). Journal of Biological Chemistry 1989 264 20961-20967.
6. Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE & Miller WL. Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues. PNAS 1987 84 407-411.
7. Bradshaw KD, Waterman MR, Couch RT, Simpson ER & Zuber MX. Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency. Molecular Endocrinology 1987 1 348-354.
8. Picado-Leonard J & Miller WL. Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21. DNA 1987 6 439-448.
9. Enberg U, Farnebo LO, Wedell A, Gröndal S, Thoren M, Grimelius L et al. In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17. World Journal of Surgery 2001 25 957-966.
10. Nocaudie-Calzada M, Huglo D, Lambert M, Ernst O, Proye C, Wemeau JL & Marcharidise X. Efficacy of iodine-131 6-beta-methyl-iodo-19-norcholesterol scintigraphy and computed tomography in patients with primary aldosteronism. European Journal of Nuclear Medicine 1999 26 1326-1332.
11. Magill SB, Raff H, Shaker JL, Brickner RC, Knechtges TE, Kehoe ME & Findling JW. Comparison of adrenal vein sampling and computed tomography in the differentiation of primary aldosteronism. Journal of Clinical Endocrinology and Metabolism 2001 86 1066-1071.
12. Lack EE. The adrenal cortex. In Functional Endocrine Pathology, 2nd edn, pp 596-636. Eds SL Asa. Oxford: Blackwell Science, 1998.
13. Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkubo M, Sawada K & Sakiyama S. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Research 1987 47 5616-5619.
14. Neville AM & Symington T. Pathology of primary aldosteronism. Cancer 1966 19 1854-1868.
15. Farnebo F, Enberg U, Grimelius L, Bäckdahl M, Schalling M, Larsson C & Farnebo LO. Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism 1997 82 3481-3486.
16. Fallo F, Pezzi V, Barzon L, Mulatero P, Veglio F, Sonino N & Mathis JM. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. European Journal of Endocrinology 2002 147 795-802.
17. Sasano H. Localization of steroidogenic enzymes in adrenal cortex and its disorders. Endocrine Journal 1994 41 471-482.
18. Irony I, Kater CE, Biglieri EG & Shackleton CH. Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma. American Journal of Hypertension 1990 3 576-582.
19. Cook DM. Adrenal mass. Endocrinology and Metabolism Clinics of North America 1997 26 829-852.
20. Young WF Jr. Management approaches to adrenal incidentalomas. A view from Rochester, Minnesota. Endocrinology and Metabolism Clinics of North America 2000 29 159-185.
21. Bulow B & Ahren B. Adrenal incidentaloma - experience of a standardized diagnostic programme in the Swedish prospective study. Journal of Internal Medicine 2002 252 239-246.
22. Siren J, Välimäki M, Huikuri K, Sivula A, Voutilainen P & Haapiainen R. Adrenalectomy for primary aldosteronism: long-term follow-up study in 29 patients. World Journal of Surgery 1998 22 418-422.
23. Rutherford JC, Taylor WL, Stowasser M & Gordon RD. Success of surgery for primary aldosteronism judged by residual autonomous aldosterone production. World Journal of Surgery 1998 22 1243-1245.
24. Favia G, Lumachi F, Scarpa V & D'Amico DF. Adrenalectomy in primary aldosteronism: a long-term follow-up study in 52 patients. World Journal of Surgery 1992 16 680-684.
25. Curnow KM, Mulatero P, Emeric-Blanchouin N, Aupetit-Faisant B, Corvol P & Pascoe L. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme. Nature Structural Biology 1997 4 32-35.