Synthesis of the carbon-14 labeled isotopomers of (R)-N-methyl-3-[2- methylphenoxyl]-benzenepropanamine hydrochloride (atomoxetine hydrochloride, LY139603), and two of its metabolites

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 47, Issue 9, 2004, Pages 615-625

  Kuo, Fengjiun ^a   Clodfelter, Dean K ^a   Wheeler, William J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

LY139603 14C ; S (+) 3 chloro 1 phenyl 1 propanol 1 14C ; Straterra

Indexed keywords

CARBON; CHLORINE COMPOUNDS; KETONES; PROPANOL;

1-PROPANOL; CARBON 14; ISOTOPOMERS; L-PROPANOL; LY139603-[ 14C]; POTENT INHIBITOR; PRESYNAPTIC; S-(+)-3-CHLORO-1-PHENYL-1-PROPANOL-[1-14C]; STRATERRA; SYNTHESISED;

METABOLITES;

3 CHLORO 1 PHENYL 1 PROPANOL C 14; ATOMOXETINE; ATOMOXETINE C 14; BENZENE DERIVATIVE; DRUG METABOLITE; N METHYL 3 (2 METHYL 4 HYDROXYPHENOXY)BENZENEPROPANAMINE C 14; N METHYL 3 (2 METHYLPHENOXY)BENZENEPROPANAMINE C 14; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VINYL DERIVATIVE; VINYL TRI N BUTYLSTANNATE;

CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; MITSUNOBU REACTION; RADIOCHEMISTRY; REACTION ANALYSIS; STILLE REACTION;

EID: 4344629176     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.849     Document Type: Conference Paper

References (7)

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2. Sauer JM, Ponsler GD, Mattiuz EL, Lond AJ, Witcher JW, Thomasson HR, DeSante KA. Disposition and metabolic fate of Atomoxetine HCI: the role of CYP2D6 in human disposition and metabolism. Drug Metab Dispos 2003; 31: 98-107.
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