Changes in c-fos expression in the rat during morphine withdrawal. Involvement of α2-adrenoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 370, Issue 1, 2004, Pages 17-25

  González Cuello, Ana ^a   Milanés, M Victoria ^a   Aviles, Manuel ^a   Laorden, M Luisa ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

HPLC; Immunohistochemistry; Naloxone precipitated withdrawal; Prazosin; Propranolol; Western blot; Yohimbine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; MORPHINE; NALOXONE; NORADRENALIN; PRAZOSIN; PROPRANOLOL; PROTEIN C FOS; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE NERVE CELL; CELL NUCLEUS; CONTROLLED STUDY; DRUG WITHDRAWAL; GENE EXPRESSION; HEART INNERVATION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART RIGHT VENTRICLE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; ONCOGENE C FOS; PROTEIN EXPRESSION; RAT; RECEPTOR INTRINSIC ACTIVITY; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; GENE EXPRESSION; GENES, FOS; HEART VENTRICLES; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; MYOCYTES, CARDIAC; NALOXONE; NORMETANEPHRINE; PRAZOSIN; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS; YOHIMBINE;

EID: 4344601441     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Aanta R, Marjamäki A, Scheinin M (1995) Molecular pharmacology of alpha 2-adrenoreceptor subtypes. Ann Med 27:439-449
2. Angel P, Karin M (1991) Phorbol ester-inducible genes contain a common Cis element recognized by a TPA-modulated transacting factor. Biochem Biophys Acta 1072:129-157
3. Blendy JA, Maldonado R (1998) Genetic analysis of drug addiction: the role of cAMP response element binding proteins. J Mol Med 76:104-110
4. Caillé S, Espejo EF, Reneric JP, Cador M, Koob GF, Stinus L (1999) Total neurochemical lesion of noradrenergic neurons of the locus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 290:881-892
5. Cicero T, Meyer ER, Bell RD (1974) Effects of phenoxybenzamine on the narcotic withdrawal syndrome in the rat. Neuropharmacology 13:601-607
6. Curran E, Akil H, Watson S (1996) Psychomotor stimulant-and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitised animals. Neurochem Res 21:1425-1435
7. Euger M, Tommasello A, Schwartz R, Clinton M (1998) Clonidine use and abuse among methadone program applicants and patients. J Subst Abuse Treat 15:589-593
8. Fuertes G, Laorden ML, Milanés MV (2000) Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal. Neuroendocrinology 71:60-67
9. González-Cuello A, Milanés MV, Castells MT, Laorden ML (2003) Activation of c-fos expression in the heart after morphine but not U-50,488H withdrawal. Br J Pharmacol 138:626-633
10. Hannan RD, West AK (1991) Adrenergic agents, but not triiodo-L-thyronine induce c-fos expression in the rat heart. Basic Res Cardiol 86:154-164
11. Hannan RD, Stennard FA, West AK (1993) Expression of c-fos and related genes in the rat heart in response to norepinephrine. J Mol Cell Cardiol 25:1137-1148
12. Laorden ML, Castells MT, Martínez MD, Martínez PJ, Milanés MV (2000a) Activation of c-fos expression in hypothalamic nuclei by mu-and kappa-receptor agonists. Correlation with catecholaminergic activity in the hypothalamic paraventricular nucleus. Endocrinology 141:1366-1376
13. Laorden ML, Fuertes G, González-Cuello A, Milanés MV (2000b) Changes in catecholaminergic pathways innervating paraventricular nucleus and pituitary-adrenal axis response during morphine dependence: implication of α1-and α2-adrenoceptors. J Pharmacol Exp Ther 293:578-584
14. Laorden ML, Castells MT, Milanés MV (2002a) Effects of morphine and morphine withdrawal on brainstem neurons innervating hypothalamic nuclei that control the pituitary-adrenocortical axis in rats. Br J Pharmacol 136:67-75
15. Laorden ML, Nuñez C, Almela P, Milanés MV (2002b) Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones. J Neurochem 83:132-140
16. Larsen TJ, Skar R, Frotjold EK, Haukanes K, Greve G, Saetersdal T (1998) Regional activation of the immediate-early response gene c-fos in infarcted rat hearts. Int J Exp Pathol 79:163-172
17. Maldonado R (1997) Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence. Neurosci Biobehav Rev 1:91-104
18. Milanés MV, Laorden ML (1998) Effects of U-50,488H withdrawal on catecholaminergic neurones of the rat ventricle. Br J Pharmacol 124:1060-1064
19. 2-adrenoceptors. Eur J Pharmacol 397:311-318
20. Milanés MV, Laorden ML, Chapleur-Chateau M, Burlet A (1998) Alterations in corticotropin-releasing factor and vasopressin content in rat brain during morphine withdrawal. Correlation with hypothalamic noradrenergic pituitary-adrenal response. J Pharmacol Exp Ther 285:700-706
21. Milanés MV, Fuente T, Laorden ML (2000) Catecholaminergic activity and 3′,5′-cyclic adenosine monophosphate levels in heart right ventricle after naloxone induced withdrawal. Naunyn-Schmiedebergs Arch Pharmacol 361:61-66
22. Millan MG, Newman-Tancredi A, Audinot V, Cussac D, Lejeune F, Nicolas JP, Coge F, Galizzi JP, Boutin JA, Rivet JM, Dekeyne A, Gobert A (2000) Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha (2)-adrenergic receptors (AR)s, serotonin (5HT) (1A9, 5-HT (1B9, 5-HT (1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse 35:79-95
23. Mizukami Y, Yoshida K (1997) Mitogen-activated prokinase translocates to the nucleus during ischaemia and activated during reperfusion. Biochemistry 323:785-790
24. Morales L, Pérez-García C, Aguacil LF (2001) Effects of yohimbine on the antinociceptive and place conditioning effects of opioid agonists in rodents. Br J Pharmacol 133:172-178
25. Morgan JI, Curran T (1991) Stimulus transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 14:421-451
26. Neal BS, Sparber SB (1985) Detanserin and pirenperone attenuate morphine withdrawal induced suppression of food reinforced autoshaped behaviour. Pharmacologist 27:224-230
27. Nestler EJ (1992) Molecular mechanism of drug addiction. J Neurosci 278:58-63
28. Nestler EJ, Aghajanian CK (1997) Molecular and cellular basis of addiction. Science 278:58-63
29. Rabadán JV, Milanés MV, Laorden ML (1998) Changes in right atria catecholamines content in naive rats and after naloxone-induced withdrawal. Br J Anaesth 80:354-359
30. 2-adrenoceptors regulating monoamine synthesis in the brain of morphine dependent rats. Naunyn-Schmiedebergs Arch Pharmacol 365:210-219
31. Singh VP, Jain NK, Kulkarni SK (2003) Fluoxetine suppresses morphine tolerance and dependence: modulation of NO-cGMP/DA/serotoninergic pathways. Methods Find Exp Clin Pharmacol 25:273-280
32. Taylor JR, Lewis JD, Elsworth JC, Charney DS, Jablons DR, Roth RH, Redmond DE, Maas JW (1991) Yohimbine co-treatment during chronic morphine administration attenuates naloxone precipitated withdrawal without diminishing tail-lick analgesia in rats. Psychopharmacology 103:407-414
33. Ueyama T, Umemoto S, Senba E (1996) Immobilization stress induces c-fos and c-jun immediate early genes expression in the heart. Life Sci 59:339-347
34. Ueyama T, Yoshida KI, Senba E (1999) Emotional stress induced immediate-early gene expression in rat heart via activation of alpha and beta-adrenoceptors. Am J Physiol 277:H1553-H1561
35. Valeri P, Martinelli B, Pimpinella G, Severini C (1988) Effects of dapripazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Naunyn-Schmiedebergs Arch Pharmacol 23:73-77
36. 2 receptors. Naunyn-Schmiedebergs Arch Pharmacol 359:293-298
37. Wiechelman KJ, Braund RD, Fitzpatrick JD (1988) Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for colour formation. Anal Biochem 175:231-237
38. Williams JT, Christie MJ, Manzoni O (2001) Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 81:299-343