Cellular and molecular characterization of a murine non-union model

Journal of Orthopaedic Research

Volumn 22, Issue 5, 2004, Pages 1100-1107

  Choi, P ^a   Ogilvie, C ^a   Thompson, Z ^a   Miclau, T ^a   Helms, J A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipose; Delayed; Distraction; Fibrous; Healing; Non union; Repair

Indexed keywords

CD31 ANTIGEN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; BONE REMODELING; BONE TISSUE; CARTILAGE; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE MODEL; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PSEUDARTHROSIS; REPRODUCIBILITY;

ANIMALS; ANTIGENS, CD31; BIOMECHANICS; BONE REGENERATION; IMMUNOHISTOCHEMISTRY; MICE; MODELS, ANIMAL; OSTEOGENESIS, DISTRACTION; WOUND HEALING;

EID: 4344586039     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2004.03.008     Document Type: Article

References (38)

1. Albrect U. Eichele G. Helms J.A. Lin H. Visualization of gene expression patterns by in situ hybridization In: Daston G.P.(Ed.) Molecular and cellular methods in developmental toxicology 1997 23-48 CRC Press Boca Raton
2. Aronson J. The biology of distraction osteogenesis In: Maiochhi A.B. Aronson J.(Eds.) perative principles of Ilizarov. Fracture treatment, nonunion, osteomyelitis, lengthening, deformity correction 1991 42-52 Williams and Wilkins Baltimore
3. Aronson J. Limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method J. Bone Joint Surg. Am. 79 1997 1243-1258
4. Brownlow H.C. Reed A. Simpson A.H. The vascularity of atrophic non-unions Injury 33 2002 145-150
5. Brownlow H.C. Simpson A.H. Metabolic activity of a new atrophic nonunion model in rabbits J. Orthop. Res. 18 2000 438-442
6. Bruder S.P. Fink D.J. Caplan A.I. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy J. Cell Biochem. 56 1994 283-294
7. Carter D.R. Beaupre G.S. Giori N.J. Helms J.A. Mechanobiology of skeletal regeneration Clin. Orthop. 355S 1998 41-55
8. Colnot C. Thompson Z. Miclau T. Werb Z. Helms J.A. Altered fracture repair in the absence of MMP9 Development 130 2003 4123-4133
9. Ducy P. Zhang R. Geoffroy V. et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 1997 747-754
10. Einhorn T.A. The cell and molecular biology of fracture healing Clin. Orthop. 355S 1998 S7-S21
11. Einhorn T.A. Lane J.M. Burstein A.H. et al. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study J. Bone Joint Surg. Am. 66 1984 274-279
12. Fischgrund J. Paley D. Suter C. Variables affecting time to bone healing during limb lengthening Clin. Orthop. 301 1994 31-37
13. Fujita M. Matsui N. Tsunoda M. Saura R. Establishment of a non-union model using muscle interposition without osteotomy in rats Kobe J. Med. Sci. 44 1998 217-233
14. Gerber H.P. Vu T.H. Ryan A.M. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation Nat. Med. 5 1999 623-628
15. Glowacki J. Angiogenesis in fracture repair Clin. Orthop. 355S 1998 S82-S89
16. Heissig B. Hattori K. Friedrich M. et al. Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases Curr. Opin. Hematol. 10 2003 136-141
17. Hietaniemi K. Peltonen J. Paavolainen P. An experimental model for non-union in rats Injury 26 1995 681-686
18. Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues: Part I. The influence of stability of fixation and soft-tissue preservation Clin. Orthop. 91 1989 249-281
19. Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction Clin. Orthop. 91 1989 63-85
20. Kloen P. Doty S.B. Gordon E. et al. Expression and activation of the BMP-signaling components in human fracture nonunions J. Bone Joint Surg. Am. 84 2002 1909-1918
21. Krebsbach P.H. Mankani M.H. Satomura K. et al. Repair of craniotomy defects using bone marrow stromal cells Transplantation 66 1998 1272-1278
22. Li G. et al. Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis J. Orthop. Res. 20 2002 779-788
23. Mayr E. Frankel V. Riiter A. Ultrasound: an alternative healing method for nonunions? Arch. Orthop. Trauma Surg. 120 2000 1-8
24. Miyauchi A. Alvarez J. Greenfield E.M. Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts J. Biol. Chem. 266 1991 20369-20374
25. Oni O.O. A non-union model of the rabbit tibial diaphysis Injury 26 1995 619-622
26. Praemer A. Furner S. Rice D.P. Musculoskeletal conditions in the United States 1992 American Academy of Orthopaedic Surgeons Park Ridge, IL
27. Reed A.A. Joyner C.J. Brownlow H.C. Simpson A.H. Human atrophic fracture non-unions are not avascular J. Orthop. Res. 20 2002 593-599
28. Sharrard W.J. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures [see comments] J. Bone Joint Surg. Br. 72 1990 347-355
29. Stafford H. Oni O.O. Hay J. Gregg P.J. An investigation of the contribution of the extraosseous tissues to the diaphyseal fracture callus using a rabbit tibial fracture model and in situ immunocytochemical localisation of osteocalcin J. Orthop. Trauma. 6 1992 190-194
30. Szczesny G. Molecular aspects of bone healing and remodeling Pol. J. Pathol. 53 2002 145-153
31. Tajana G.F. Morandi M. Zembo M.M. The structure and development of osteogenetic repair tissue according to Ilizarov technique in man. Characterization of extracellular matrix Orthopedics 12 1989 515-523
32. Tay B.K. Le A.X. Gould S.E. Helms J.A. Histochemical and molecular analyses of distraction osteogenesis in a mouse model J. Orthop. Res. 16 1998 636-642
33. Thompson Z.T. Miclau T. Hu D. Helms J.A. A model for intramembranous ossification during fracture healing J. Orthop. Res. 20 2002 1091-1098
34. Triffitt P.D. Cieslak C.A. Gregg P.J. A quantitative study of the routes of blood flow to the tibial diaphysis after an osteotomy J. Orthop. Res. 11 1993 49-57
35. Vu T.H. Shipley J.M. Bergers G. et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes Cell 93 1998 411-422
36. Wallace A.L. Draper E.R. Strachan R.K. et al. The effect of devascularisation upon early bone healing in dynamic external fixation J. Bone Joint Surg. Br. 73 1991 819-825
37. White S.H. Kenwright J. The timing of distraction of an osteotomy J. Bone Joint Surg. Br. 72 1990 356-361
38. Yoo J.U. Johnstone B. The role of osteochondral progenitor cells in fracture repair Clin. Orthop. 355S 1998 S73-S78