New approach to association testing in case-parent designs under informative parental missingness

Genetic Epidemiology

Volumn 27, Issue 2, 2004, Pages 131-140

  Chen, Yi Hau ^a  

^a INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

Author keywords

Conditional likelihood; Genotype relative risk; Informative missingness; Parental control

Indexed keywords

ARTICLE; FAMILY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MODEL; GENOTYPE; MATING; PARENT; PROGENY;

GENETIC PREDISPOSITION TO DISEASE; GENETIC TECHNIQUES; GENOTYPE; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; PARENTS;

EID: 4344581237     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.20004     Document Type: Article

References (18)

1. Allen AS, Rathouz, PJ, Satten GA. 2003. Informative missingness in genetic association studies: case-parent designs. Am J Hum Genet 72:671-680.
2. Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain haplotype transmission. Am J Hum Genet 65:1170-1177.
3. Curtis D, Sham PC. 1995. A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 56:811-812.
4. Hartl DL. 1988. A primer of population genetics, 2nd ed. Sunderland, MA: Sinauer Associates.
5. Kaplan NL, Morris RW. 2002. Comment: adjusting for population heterogeneity and mis-specified haplotype frequencies when testing nonparametric null hypotheses in statistical genetics. J Am Stat Assoc 97:753-754.
6. Little RJA, Rubin D. 2002. Statistical analysis with missing data. 2nd ed. Chichester: John Wiley.
7. Rabinowitz D. 2002. Adjusting for population heterogeneity and misspecified haplotype frequencies when testing nonparametric null hypotheses in statistical genetics. Am J Stat Assoc 97:742-758.
8. Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedegree structure and arbitrary missing marker information. Hum Hered 50:211-223.
9. Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
10. Schaid DJ. 1996. General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449.
11. Schaid DJ. 2002. Comment: adjusting for population heterogeneity and mis-specified haplotype frequencies when testing nonparametric null hypotheses in statistical genetics. J Am Stat Assoc 97:754-756.
12. Schaid DJ, Sommer SS. 1993. Genotype risk ratio: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 53:127-130.
13. Schaid DJ, Sommer SS. 1994. Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402-409.
14. Spielman RS, Ewens WJ. 1996. The TDT and other family-based tests for linkage-disequilibrium and association. Am J Hum Genet 59:983-989.
15. Spielman RS, McGinnis RE, Ewens WJ. 1993. The transmission test for linkage disequilibrium: the insulin gene and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
16. Sun F, Flanders WD, Yang Q, Khoury MJ. 1999. Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT. Am J Epidemiol 150:97-104.
17. Weinberg CR. 1999. Allowing for missing parents in genetic studies of case-parent triads. Am J Hum Genet 64:1186-1193.
18. Weinberg CR, Wilcox AJ, Lie RT. 1998. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62:969-978.