Loss of function in virus-specific lung effector T cells is independent of infection

Journal of Leukocyte Biology

Volumn 83, Issue 3, 2008, Pages 564-574

  Arimilli, Subhashini ^a   Palmer, Ellen M ^a   Alexander Miller, Martha A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

CD8; CTL; Regulation; Respiratory tract

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONFERENCE PAPER; CONTROLLED STUDY; EFFECTOR CELL; IMMUNOREGULATION; IN VIVO STUDY; LUNG INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SIMIAN PARAINFLUENZA VIRUS 5; VIRUS INFECTION; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; FEMALE; IMMUNOLOGY; LUNG; LUNG DISEASE; PATHOLOGY; SPLEEN; T LYMPHOCYTE; VACCINIA; VIROLOGY;

PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS; SIMIAN VIRUS 5;

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; LUNG; LUNG DISEASES; MICE; MICE, INBRED BALB C; SPLEEN; T-LYMPHOCYTES; VACCINIA; VIRUS DISEASES;

EID: 43349102040     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0407215     Document Type: Conference Paper

References (38)

1. Hou, S., Doherty, P. C., Zijlstra, M., Jaenisch, R., Katz, J. M. (1992) Delayed clearance of Sendai virus in mice lacking class I MHC- restricted CD8+ T cells. J. Immunol. 149, 1319-1325.
2. + T cells in primary and secondary influenza pneumonia. Immunity 8, 683-691.
3. + T cells are the initial population elicited following viral infection of the respiratory tract. J. Immunol. 170, 174-181.
4. Gray, P. M., Arimilli, S., Palmer, E. M., Parks, G. D., Alexander-Miller, M. A. (2005) Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. J. Virol. 79, 3339-3349.
5. + T-cell memory in the respiratory tract. Nat. Med. 8, 54-60.
6. Vallbracht, S., Unsold, H., Ehl, S. (2006) Functional impairment of cytotoxic T cells in the lung airways following respiratory virus infections. Eur. J. Immunol. 36, 1434-1442.
7. Claassen, E. A., van der Kant, P. A., Rychnavska, Z. S., van Bleek, G. M., Easton, A. J., van der Most, R. G. (2005) Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J. Immunol. 175, 6597-6604.
8. Bonfield, T. L., Konstan, M. W., Burfeind, P., Panuska, J. R., Hilliard, J. B., Berger, M. (1995) Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 13, 257-261.
9. Xu, W., Zheng, S., Dweik, R. A., Erzurum, S. C. (2006) Role of epithelial nitric oxide in airway viral infection. Free Radic. Biol. Med. 41, 19-28.
10. Bingisser, R. M., Holt, P. G. (2001) Immunomodulating mechanisms in the lower respiratory tract: nitric oxide mediated interactions between alveolar macrophages, epithelial cells, and T-cells. Swiss Med. Wkly. 131, 171-179.
11. Bruder, D., Srikiatkhachorn, A., Enelow, R. I. (2006) Cellular immunity and lung injury in respiratory virus infection. Viral Immunol. 19, 147-155.
12. Holt, P. G., Oliver, J., Bilyk, N., McMenamin, C., McMenamin, P. G., Kraal, G., Thepen, T. (1993) Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J. Exp. Med. 177, 397-407.
13. Bingisser, R. M., Tilbrook, P. A., Holt, P. G., Kees, U. R. (1998) Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J. Immunol. 160, 5729-5734.
14. Huang, M., Sharma, S., Mao, J. T., Dubinett, S. M. (1996) Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production. J. Immunol. 157, 5512-5520.
15. Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., Shevach, E. M. (1993) IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151, 1224-1234.
16. Soltys, J., Bonfield, T., Chmiel, J., Berger, M. (2002) Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages. J. Immunol. 168, 1903-1910.
17. Macatonia, S. E., Doherty, T. M., Knight, S. C., O'Garra, A. (1993) Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-γ production. J. Immunol. 150, 3755-3765.
18. Groux, H., Bigler, M., de Vries, J. E., Roncarolo, M. G. (1996) Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med. 184, 19-29.
19. De Waal Malefyt, R., Yssel, H., de Vries, J. E. (1993) Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J. Immunol. 150, 4754-4765.
20. Cook, G., Campbell, J. D., Carr, C. E., Boyd, K. S., Franklin, I. M. (1999) Transforming growth factor β from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes. J. Leukoc. Biol. 66, 981-988.
21. Jarnicki, A. G., Lysaght, J., Todryk, S., Mills, K. H. (2006) Suppression of antitumor immunity by IL-10 and TGF-β-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J. Immunol. 177, 896-904.
22. Lauvau, G., Vijh, S., Kong, P., Horng, T., Kerksiek, K., Serbina, N., Tuma, R. A., Pamer, E. G. (2001) Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science 294, 1735-1739.
23. Alexander-Miller, M. A., Leggatt, G. R., Berzofsky, J. A. (1996) Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93, 4102-4107.
24. Gray, P. M., Parks, G. D., Alexander-Miller, M. A. (2001) A novel CD8-independent high-avidity cytotoxic T-lymphocyte response directed against an epitope in the phosphoprotein of the paramyxovirus simian virus 5. J. Virol. 75, 10065-10072.
25. Wansley, E. K., Dillon, P. J., Gainey, M. D., Tam, J., Cramer, S. D., Parks, G. D. (2005) Growth sensitivity of a recombinant simian virus 5 P/V mutant to type I interferon differs between tumor cell lines and normal primary cells. Virology 335, 131-144.
26. Galkina, E., Thatte, J., Dabak, V., Williams, M. B., Ley, K., Braciale, T. J. (2005) Preferential migration of effector CD8+ T cells into the interstitium of the normal lung. J. Clin. Invest. 115, 3473-3483.
27. McChesney, M. B., Oldstone, M. B. (1987) Viruses perturb lymphocyte functions: selected principles characterizing virus-induced immunosuppression. Annu. Rev. Immunol. 5, 279-304.
28. Seet, B. T., Johnston, J. B., Brunetti, C. R., Barrett, J. W., Everett, H., Cameron, C., Sypula, J., Nazarian, S. H., Lucas, A., McFadden, G. (2003) Poxviruses and immune evasion. Annu. Rev. Immunol. 21, 377-423.
29. Spriggs, M. K. (1996) One step ahead of the game: viral immunomodulatory molecules. Annu. Rev. Immunol. 14, 101-130.
30. Hogan, R. J., Usherwood, E. J., Zhong, W., Roberts, A. A., Dutton, R. W., Harmsen, A. G., Woodland, D. L. (2001) Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections. J. Immunol. 166, 1813-1822.
31. Baumgarth, N., Kelso, A. (1996) Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection. Eur. J. Immunol. 26, 2189-2197.
32. Harris, N. L., Watt, V., Ronchese, F., Le Gros, G. (2002) Differential T cell function and fate in lymph node and nonlymphoid tissues. J. Exp. Med. 195, 317-326.
33. Bluestone, J. A., Abbas, A. K. (2003) Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253-257.
34. Ely, K. H., Cookenham, T., Roberts, A. D., Woodland, D. L. (2006) Memory T cell populations in the lung airways are maintained by continual recruitment. J. Immunol. 176, 537-543.
35. Stevenson, P. G., Doherty, P. C. (1998) Kinetic analysis of the specific host response to a murine γherpesvirus. J. Virol. 72, 943-949.
36. + T cells during experimental virus infection. J. Immunol. 167, 4254-4260.
37. Xu, L., Yoon, H., Zhao, M. Q., Liu, J., Ramana, C. V., Enelow, R. I. (2004) Cutting edge: pulmonary immunopathology mediated by antigen-specific expression of TNF-α by antiviral CD8+ T cells. J. Immunol. 173, 721-725.
38. + T cell recognition. J. Clin. Invest. 106, R49-R58.