Optimising post-conditioning time of marginal donor livers

Langenbeck's Archives of Surgery

Volumn 393, Issue 3, 2008, Pages 311-316

  Manekeller, Steffen ^a   Seinsche, Alexandra ^a   Stegemann, Judith ^a   Hirner, Andreas ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Apoptosis; ATP concentration; Cold storage; Machine perfusion; Post conditioning

Indexed keywords

ADENOSINE TRIPHOSPHATE; ENZYME; HISTIDINE; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLD; COMPARATIVE STUDY; CONTROLLED STUDY; CRYOPRESERVATION; ENZYME RELEASE; HEART ARREST; HEPATOBILIARY SYSTEM; IN VITRO STUDY; LIVER; MALE; NONHUMAN; ORGAN DONOR; PERFUSION; PRIORITY JOURNAL; RAT; REPERFUSION; TIME; WISTAR RAT;

EID: 43349100170     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-008-0288-4     Document Type: Article

References (34)

1. 1. PL Abt NM Desai MD Crawford LM Forman JW Markmann KM Olthoff JF Markmann 2004 Survival following liver transplantation from non-heart-beating donors Ann Surg 239 87 92 14685105 10.1097/01.sla.0000103063.82181.2c Abt PL, Desai NM, Crawford MD, Forman LM, Markmann JW, Olthoff KM, Markmann JF (2004) Survival following liver transplantation from non-heart-beating donors. Ann Surg 239:87–92
2. 2. Manekeller S, Schuppius A, Stegemann J, Hirner A, Minor T (2007) Role of perfusion medium, oxygen and rheology for endoplasmic reticulum stress-induced cell death after hypothermic machine preservation of the liver. Transpl Int 21:196–177
3. 3. RH Tolba K Yonezawa S Song C Burger T Minor 2004 Synergistic value of fibrinolysis and hypothermic aerobic preservation with oxygen in the protection of livers from non-heart-beating donors: an experimental model Transplant Proc 36 2927 2930 15686662 10.1016/j.transproceed.2004.11.094 1:CAS:528:DC%2BD2MXitVemtL8%3D Tolba RH, Yonezawa K, Song S, Burger C, Minor T (2004) Synergistic value of fibrinolysis and hypothermic aerobic preservation with oxygen in the protection of livers from non-heart-beating donors: an experimental model. Transplant Proc 36:2927–2930
4. 4. MH Maathuis S Manekeller A Plaats van der HG Leuvenink NA ‘t Hart AB Lier G Rakhorst RJ Ploeg T Minor 2007 Improved kidney graft function after preservation using a novel hypothermic machine perfusion device Ann Surg 246 982 991 18043100 10.1097/SLA.0b013e31815c4019 Maathuis MH, Manekeller S, van der Plaats A, Leuvenink HG, ‘t Hart NA, Lier AB, Rakhorst G, Ploeg RJ, Minor T (2007) Improved kidney graft function after preservation using a novel hypothermic machine perfusion device. Ann Surg 246:982–991
5. 5. T Minor P Olschewski RH Tolba S Akbar M Kocálková F Dombrowski 2002 Liver preservation with HTK: salutary effect of hypothermic aerobiosis by either gaseous oxygen or machine perfusion Clin Transplant 16 206 211 12010145 10.1034/j.1399-0012.2002.01128.x Minor T, Olschewski P, Tolba RH, Akbar S, Kocálková M, Dombrowski F (2002) Liver preservation with HTK: salutary effect of hypothermic aerobiosis by either gaseous oxygen or machine perfusion. Clin Transplant 16:206–211
6. 6. S Manekeller H Leuvenink M Sitzia T Minor 2005 Oxygenated machine perfusion preservation of predamaged kidneys with HTK and Belzer machine perfusion solution: an experimental study in pigs Transplant Proc 37 3274 3275 16298570 10.1016/j.transproceed.2005.09.034 1:CAS:528:DC%2BD2MXht1aqtrrK Manekeller S, Leuvenink H, Sitzia M, Minor T (2005) Oxygenated machine perfusion preservation of predamaged kidneys with HTK and Belzer machine perfusion solution: an experimental study in pigs. Transplant Proc 37:3274–3275
7. 7. T Minor S Manekeller M Sioutis F Dombrowski 2006 Endoplasmic and vascular surface activation during organ preservation: refining upon the benefits of machine perfusion Am J Transplant 6 1355 1366 16686759 10.1111/j.1600-6143.2006.01338.x 1:CAS:528:DC%2BD28XlvVyhtLY%3D Minor T, Manekeller S, Sioutis M, Dombrowski F (2006) Endoplasmic and vascular surface activation during organ preservation: refining upon the benefits of machine perfusion. Am J Transplant 6:1355–1366
8. 8. T Minor S Saad M Kötting M Nagelschmidt W Isselhard 1997 Short term restoration by gaseous oxygen for long term preservation of predamaged livers from non heart beating donors Transplant Proc 29 3474 3475 9414798 10.1016/S0041-1345(97)00985-8 1:CAS:528:DyaK1cXht1ansg%3D%3D Minor T, Saad S, Kötting M, Nagelschmidt M, Isselhard W (1997) Short term restoration by gaseous oxygen for long term preservation of predamaged livers from non heart beating donors. Transplant Proc 29:3474–3475
9. 9. SD St Peter CJ Imber PJ Friend 2002 Liver and kidney preservation by perfusion Lancet 359 604 613 11867131 10.1016/S0140-6736(02)07749-8 St Peter SD, Imber CJ, Friend PJ (2002) Liver and kidney preservation by perfusion. Lancet 359:604–613
10. 10. T Minor W Isselhard 1996 Synthesis of high energy phosphates during cold ischemic rat liver preservation with gaseous oxygen insufflation Transplantation 61 20 22 8560566 10.1097/00007890-199601150-00005 1:CAS:528:DyaK28Xht1GitL0%3D Minor T, Isselhard W (1996) Synthesis of high energy phosphates during cold ischemic rat liver preservation with gaseous oxygen insufflation. Transplantation 61:20–22
11. 11. DE Pegg 1986 Organ preservation Surg Clin North Am 66 617 632 3520898 1:STN:280:DyaL283jsF2mtg%3D%3D Xu H, Lee CY, Clemens MG, Zhang JX (2004) Prolonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers. Transplantation 77:1676–1682
12. 12. T Minor H Klauke B Vollmar W Isselhard MD Menger 1997 Biophysical aspects of liver aeration by vascular persufflation with gaseous oxygen Transplantation 63 1843 1846 9210516 10.1097/00007890-199706270-00025 1:STN:280:DyaK2szlsVahsA%3D%3D Minor T, Klauke H, Vollmar B, Isselhard W, Menger MD (1997) Biophysical aspects of liver aeration by vascular persufflation with gaseous oxygen. Transplantation 63:1843–1846
13. 13. BJ Fuller AL Busza E Proctor 1990 Possible resuscitation of liver function by hypothermic reperfusion in vitro after prolonged (24 h) cold preservation—a 31p NMR study Transplantation 50 511 513 2402798 10.1097/00007890-199009000-00030 1:STN:280:DyaK3czosFGlsQ%3D%3D Fuller BJ, Busza AL, Proctor E (1990) Possible resuscitation of liver function by hypothermic reperfusion in vitro after prolonged (24 h) cold preservation—a 31p NMR study. Transplantation 50:511–513
14. 14. S Manekeller V Dobberahn A Hirner T Minor 2007 Liver integrity after warm ischemia in situ and brief preservation ex vivo: The value of aerobic post-conditioning Cryobiology 55 249 254 17892868 10.1016/j.cryobiol.2007.08.005 Manekeller S, Dobberahn V, Hirner A, Minor T (2007) Liver integrity after warm ischemia in situ and brief preservation ex vivo: The value of aerobic post-conditioning. Cryobiology 55:249–254
15. 15. S Manekeller T Minor 2006 Possibility of conditioning predamaged grafts after cold storage: influences of oxygen and nutritive stimulation Transplant Int 19 667 674 10.1111/j.1432-2277.2006.00320.x 1:CAS:528:DC%2BD28XptFWkt7s%3D Manekeller S, Minor T (2006) Possibility of conditioning predamaged grafts after cold storage: influences of oxygen and nutritive stimulation. Transplant Int 19:667–674
16. 16. T Minor S Manekeller 2007 Assessment of hepatic integrity after ischemic preservation by isolated perfusion in vitro: The role of albumin Cryobiology 54 188 195 17324395 10.1016/j.cryobiol.2007.01.002 1:CAS:528:DC%2BD2sXjvFeht74%3D Minor T, Manekeller S (2007) Assessment of hepatic integrity after ischemic preservation by isolated perfusion in vitro: The role of albumin. Cryobiology 54:188–195
17. 17. RH Tolba S Akbar A Muller U Glatzel T Minor 2000 Experimental liver preservation with Celsior: a novel alternative to University of Wisconsin and histidine-tryptophan-alphaketoglutarate solutions? Eur Surg Res 32 142 147 10878454 10.1159/000008755 1:CAS:528:DC%2BD3cXls1Glsbg%3D Tolba RH, Akbar S, Muller A, Glatzel U, Minor T (2000) Experimental liver preservation with Celsior: a novel alternative to University of Wisconsin and histidine-tryptophan-alphaketoglutarate solutions? Eur Surg Res 32:142–147
18. 18. S Akbar T Minor 2001 Significance and molecular targets of protein kinase A during cAMP-mediated protection of cold stored liver grafts Cell Mol Life Sci 58 1708 1714 11706996 10.1007/PL00000808 1:CAS:528:DC%2BD3MXovVylt74%3D Akbar S, Minor T (2001) Significance and molecular targets of protein kinase A during cAMP-mediated protection of cold stored liver grafts. Cell Mol Life Sci 58:1708–1714
19. 19. T Minor A Hachenberg RH Tolba D Pauleit S Akbar 2001 Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion Transplantation 71 1792 1796 11455260 10.1097/00007890-200106270-00015 1:STN:280:DC%2BD3MvgtFejsg%3D%3D Minor T, Hachenberg A, Tolba RH, Pauleit D, Akbar S (2001) Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion. Transplantation 71:1792–1796
20. 20. K Vajdova R Graf PA Clavien 2002 ATP-supplies in the cold preserved liver: a long-neglected factor of organ viability Hepatology 36 1543 1552 12447882 1:CAS:528:DC%2BD38Xps1ylu7Y%3D Vajdova K, Graf R, Clavien PA (2002) ATP-supplies in the cold preserved liver: a long-neglected factor of organ viability. Hepatology 36:1543–1552
21. 21. A Lanir RL Jenkins C Caldwell RG Lee U Khettry ME Clouse 1988 Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver Hepatology 8 471 475 3286456 10.1002/hep.1840080306 1:STN:280:DyaL1c3is1CmsQ%3D%3D Lanir A, Jenkins RL, Caldwell C, Lee RG, Khettry U, Clouse ME (1988) Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver. Hepatology 8:471–475
22. 22. Manekeller S, Sioutis M, Hirner A, Minor T (2008) Influence of neoadjuvant chemotherapy on liver integrity and ischemic tolerance. Z Gastroenterol 46:17–21
23. 23. W Gao RC Bentley JF Madden PA Clavien 1998 Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation Hepatology 27 1652 1660 9620339 10.1002/hep.510270626 1:CAS:528:DyaK1cXjvVCrsrk%3D Gao W, Bentley RC, Madden JF, Clavien PA (1998) Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 27:1652–1660
24. 24. MR Schon O Kollmar S Wolf H Schrem M Matthes N Akkoc NC Schnoy P Neuhaus 2001 Liver transplantation after organ preservation with normotermic extracorporal perfusion Ann Surg 233 114 123 11141233 10.1097/00000658-200101000-00017 1:STN:280:DC%2BD3M3pvFCksQ%3D%3D Schon MR, Kollmar O, Wolf S, Schrem H, Matthes M, Akkoc N, Schnoy NC, Neuhaus P (2001) Liver transplantation after organ preservation with normotermic extracorporal perfusion. Ann Surg 233:114–123
25. 25. SD St Peter CJ Imber I Lopez D Hughes PJ Friend 2002 Extended preservation of non-heart-beating donor livers with normotermic machine perfusion Br J Sug 89 609 616 10.1046/j.1365-2168.2002.02052.x 1:STN:280:DC%2BD383jsFehug%3D%3D St Peter SD, Imber CJ, Lopez I, Hughes D, Friend PJ (2002) Extended preservation of non-heart-beating donor livers with normotermic machine perfusion. Br J Sug 89:609–616
26. 26. A Plaats van der NA ‛t Hart AM Morariu GJ Verkerke HG Leuvenink RJ Ploeg G Rakhorst 2004 Hypothermic machine preservation in liver transplantation revisited: concepts and criteria in the new millennium Ann Biomed Eng 32 623 631 15117035 10.1023/B:ABME.0000019181.18194.51 van der Plaats A, ‛t Hart NA, Morariu AM, Verkerke GJ, Leuvenink HG, Ploeg RJ, Rakhorst G (2004) Hypothermic machine preservation in liver transplantation revisited: concepts and criteria in the new millennium. Ann Biomed Eng 32:623–631
27. 27. H Lauschke P Olschewski R Tolba S Schulz T Minor 2003 Oxygenated machine perfusion mitigates surface antigen expression and improves preservation of predamaged donor livers Cryobiology 1 53 60 10.1016/S0011-2240(02)00164-5 Lauschke H, Olschewski P, Tolba R, Schulz S, Minor T (2003) Oxygenated machine perfusion mitigates surface antigen expression and improves preservation of predamaged donor livers. Cryobiology 1:53–60
28. 28. E Szegezdi U Fitzgerald A Samali 2003 Caspase-12 and ER-stressmediated apoptosis: The story so far Ann N Y Acad Sci 1010 186 194 15033718 10.1196/annals.1299.032 1:CAS:528:DC%2BD2cXisFeksbo%3D Szegezdi E, Fitzgerald U, Samali A (2003) Caspase-12 and ER-stressmediated apoptosis: The story so far. Ann N Y Acad Sci 1010:186–194
29. 29. RV Rao E Hermel S Castro-Obregon G del Rio LM Ellerby HM Ellerby DE Bredesen 2001 Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation J Biol Chem 276 33869 33874 11448953 10.1074/jbc.M102225200 1:CAS:528:DC%2BD3MXmslylt7k%3D Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 276:33869–33874
30. 30. K Vajdova R Smrekova C Mislanova M Kukan M Lutterova 2000 Cold-preservation-induced sensitivity of rat hepatocyte function to rewarming injury and its prevention by short-therm reperfusion Hepatology 32 289 296 10915735 10.1053/jhep.2000.8895 1:STN:280:DC%2BD3cvgsVWmtA%3D%3D Vajdova K, Smrekova R, Mislanova C, Kukan M, Lutterova M (2000) Cold-preservation-induced sensitivity of rat hepatocyte function to rewarming injury and its prevention by short-therm reperfusion. Hepatology 32:289–296
31. 31. P Dutkowski K Furrer Y Tian R Graf PA Clavien 2006 Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor Ann Surg 244 968 976 17122622 10.1097/01.sla.0000247056.85590.6b Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA (2006) Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg 244:968–976
32. 32. T Minor S Saad M Kötting M Nagelschmidt A Paul 1998 Endischemic oxygen persufflation to improve viability of marginally preserved donor livers Transplant Int 11 400 403 10.1007/s001470050508 Minor T, Saad S, Kötting M, Nagelschmidt M, Paul A (1998) Endischemic oxygen persufflation to improve viability of marginally preserved donor livers. Transplant Int 11:400–403
33. 33. JD Palombo JL Bowers ME Clouse A McCullough RA Forse BR Bistrian 1993 Hepatic utilisation of exogenous nucleotide precursors of restoration of ATP after cold ischemia in rats Am J Clin Nutr 57 420 427 8438778 1:CAS:528:DyaK3sXhvVylu7Y%3D Palombo JD, Bowers JL, Clouse ME, McCullough A, Forse RA, Bistrian BR (1993) Hepatic utilisation of exogenous nucleotide precursors of restoration of ATP after cold ischemia in rats. Am J Clin Nutr 57:420–427
34. 34. AL Busza BJ Fuller E Proctor 1994 Evaluation of cold reperfusion as an indicator of viability in stored organs: a 31P NMR study in rat liver Cryobiology 31 26 30 8156797 10.1006/cryo.1994.1003 1:STN:280:DyaK2c3gvVaktg%3D%3D Busza AL, Fuller BJ, Proctor E (1994) Evaluation of cold reperfusion as an indicator of viability in stored organs: a 31P NMR study in rat liver. Cryobiology 31:26–30