Liver integrity after warm ischemia in situ and brief preservation ex vivo: The value of aerobic post-conditioning

Cryobiology

Volumn 55, Issue 3, 2007, Pages 249-254

  Manekeller, Steffen ^a   Dobberahn, Viola ^a   Hirner, Andreas ^a   Minor, Thomas ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Apoptosis; Cold ischemia; Conditioning; Liver; Machine perfusion; Marginal donor; NHBD; Non heart beating donor; Organ preservation; Post conditioning; Preservation time; Transplantation; Viability; Warm ischemia

Indexed keywords

AMMONIA; HTK SOLUTION; OXYGEN;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE; COLD ISCHEMIA; CONTROLLED STUDY; EX VIVO STUDY; HEART BEAT; ISCHEMIA; LIVER; MALE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; WISTAR RAT;

AEROBIOSIS; ALANINE TRANSAMINASE; APOPTOSIS; CASPASE 9; COLD; COLLAGEN TYPE XI; HEART ARREST; HUMANS; LIVER; LIVER TRANSPLANTATION; ORGAN PRESERVATION; WARM ISCHEMIA;

RATTUS NORVEGICUS;

EID: 36248974256     PISSN: 00112240     EISSN: 10902392     Source Type: Journal    
DOI: 10.1016/j.cryobiol.2007.08.005     Document Type: Article

References (19)

1. Abt P.L., Desai N.M., Crawford M.D., Forman L.M., Markmann J.W., Olthoff K.M., and Markmann J.F. Survival following liver transplantation from non-heart-beating donors. Ann. Surg. 239 (2004) 87-92
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Brasile L., Stubenitsky B.M., Booster M.H., Arenada D., Haisch C., and Kootstra G. Hypothermia-a limiting factor in using warm ischemically damaged kidneys. Am. J. Transplant. 1 (2001) 316-320
4. Fuller B.J., Busza A.L., and Proctor E. Possible resuscitation of liver function by hypothermic reperfusion in vitro after prolonged (24-hour) cold preservation-a 31P NMR study. Transplantation 50 (1990) 511-513
5. Huguet C., Gavelli A., Chieco P.A., Bona S., Harb J., Joseph J.M., Jobard J., Gramaglia M., and Lasserre M. Liver ischemia for hepatic resection: where is the limit?. Surgery 111 (1992) 251-259
6. Kootstra G., Kievit J.K., and Heineman E. The non heart-beating donor. Br. Med. Bull. 53 (1997) 844-853
7. Manekeller S., and Minor T. Possibility of conditioning predamaged grafts after cold storage: influences of oxygen and nutritive stimulation. Transplant. Int. 19 (2006) 667-674
8. Minor T., and Kötting M. Gaseous oxygen for hypothermic preservation of predamaged liver grafts: fuel to cellular homeostasis or radical tissue alteration?. Cryobiology 40 (2000) 182-186
9. Minor T., and Manekeller S. Assessment of hepatic integrity after ischemic preservation by isolated perfusion in vitro. The role of albumin. Cryobiology 54 (2007) 188-195
10. Minor T., Manekeller S., Sioutis M., and Dombrowski F. Endoplasmic and vascular surface activation during organ preservation: refining upon the benefits of machine perfusion. Am. J. Transplant. 6 (2006) 1355-1366
11. Minor T., Saad S., Kötting M., Nagelschmidt M., and Isselhard W. Short term restoration by gaseous oxygen for long term preservation of predamaged livers from non heart beating donors. Transplant. Proc. 29 (1997) 3474-3475
12. Minor T., Saad S., Kötting M., Nagelschmidt M., and Paul A. Endischemic oxygen persufflation to improve viability of marginally preserved donor livers. Transplant. Int. 11 (1998) S400-S403
13. Minor T., Tolba R., Neumann S., Schulz S., and Sitzia M. Fibrinolysis in organ procurement for transplantation after cardiocirculatory compromise. Thromb. Haemost. 90 (2003) 361-362
14. Mora N.P., Jimenez M., Bujan J., Arahuetes R., Jurado F., Bellon J.M., Leret M.L., Tendillo F.J., and Castillo-Olivares J.L. Hepatic resuscitation after warm anoxia: one approach for increasing the donor pool for liver transplantation. Transplant. Int. 9 Suppl. 1 (1996) S120-S125
15. Schön M.R., Hunt C.J., Pegg D.E., and Wight D.G. The possibility of resuscitating livers after warm ischemic injury. Transplantation 56 (1993) 24-31
16. Schon M.R., Kollmar O., Wolf S., Schrem H., Matthes M., Akkoc N., Schnoy N.C., and Neuhaus P. Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann. Surg. 233 (2001) 114-123
17. Schön M.R., Schrem H., Lemmens H.P., Wolf S., and Neuhaus P. Erfolgreiche Transplantation von Lebern nicht herzschlagender Spender nach normothermer extrakorporaler Leberperfusion im Schweinemodell. Langenbecks Arch. Chir Suppl. Kongressbd. 114 (1997) 725-731
18. St. Peter S.D., Imber C.J., Lopez I., Hughes D., and Friend P.J. Extended preservation of non-heart-beating donor livers with normothermic machine perfusion. Br. J. Surg. 89 (2002) 609-616
19. Tojimbara T., Wicomb W.N., Garcia-Kennedy R., Burns W., Hayashi M., Collins G., and Esquivel C.O. Liver transplantation from non-heart beating donors in rats: influence of viscosity and temperature of initial flushing solutions on graft function. Liver Transpl. Surg. 3 (1997) 39-45