Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: A role for immunomodulatory proteins encoded by the left (5'-)end of the genome

Central European Journal of Biology

Volumn 3, Issue 1, 2008, Pages 19-30

  Mistríková, Jela ^a,b   Rajčáni, Július ^b  

^a Physics and Informatics   (Slovakia)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Genome deletions; Immune evasion genes; Murid gammaherpesvirus 4; Pathogenesis; Tumor formation

Indexed keywords

HERPESVIRIDAE; MURID HERPESVIRUS 4; MURIDAE; MURINE HEPATITIS VIRUS; MURINE HERPESVIRUS 72; MUS;

EID: 43349098169     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-008-0002-0     Document Type: Article

References (76)

1. Blaskovič D., Stančeková M., Svobodová J., Mistríková J., Isolation of five strains of herpesviruses from two species of free living small rodents, Acta Virol. 1980, 24, 468
2. Mistríková J., Blaškovič D., Ecology of the murine alphaherpesvirus and its isolation from lung of rodents in cell culture, Acta Virol., 1985, 29, 312-317
3. Svobodová J., Blaskovič D., Mistríková J., Growth characteristics of herpesviruses isolated from free living small rodents, Acta Virol., 1982, 26, 256-263
4. Efstathiou S., Ho Y.M., Hall S., Styles C.J., Scott S.D., Gompels U.A., Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri, J. Gen. Virol., 1990, 71, 1365-1372
5. Svobodová J., Stančekova M., Blaškovič D., Mistríková J., Leššo J., Russ G., et al., Antigenic relatedness of alphaherpesviruses isolated from free-living rodents, Acta Virol., 1982, 26, 438-443
6. Van Regenmortel M.H., Fauquet C.M., Bishop D.H., Herpesvirus family, In: Virus taxonomy: classification and nomenclature of viruses, 7th ICTV report, San Diego, New York, London, Tokyo, Academic Press, 2000, 220-226
7. Rajčáni J., Blaškovič D., Svobodová J., Čiampor F., Hučková D., Staneková D., Pathogenesis of acute and persistent murine herpesvirus infection in mice, Acta Virol., 1985, 29, 51-60
8. Rajčáni J., Bustamante de Contreras L.R., Svobodová J., Corneal inoculation of murine herpesvirus in mice: the absence of neural spread, Acta Virol., 1987, 31, 25-30
9. Blasdell K., McCracken C., Morris A., Nash T., Begon A., Bennett M., et al., The wood mouse is a natural host for Murid herpesvirus 4, J. Gen. Virol., 2003, 84, 111-113
10. Telfer S., Bennett M., Carlslake D., Helyar S., Begon M., Thy dynamics of Murid gammaherpesvirus 4 within wild, sypatric populations of bank voles and wood mice, J. Wildlife Dis., 2007, 1, 32-39
11. Sunil-Chandra N.P., Efstathiou S., Arno J., Nash A.A., Virological and pathological features of mice infected with murine gamma-herpesvirus 68, J. Gen. Virol., 1992, 73, 2347-2356
12. Sunil-Chandra N.P., Efstathiou S., Nash A.A., Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo, J. Gen. Virol., 1992, 3, 3275-3279
13. Usherwood E.J., Stewart J.P., Robertson K., Allen D.J., Nash A.A., Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice, J. Gen. Virol., 1996, 77, 2819-2825
14. Sunil-Chandra N.P., Efstathiou S., Nash A.A., Interactions of murine gammaherpesvirus 68 with B and T cell lines, Virology, 1993, 193, 825-833
15. Marques S., Efstathiou S., Smith K.G., Haury M., Simas J.P., Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes, J. Virol., 2003, 77, 7308-7318
16. Weck K.E., Kim S.S., Virgin IV H.W., Speck S.H., Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells, J. Virol., 1999, 73, 3273-3283
17. Weck K.E., Barkon M.L., Yoo L.I., Speck S.H., Virgin IV H.W., Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68, J. Virol., 1996, 70, 6775-6780
18. Stevenson P.G., Doherty P.C., Kinetic analysis of the specific host response to a murine gammaherpesvirus, J. Virol., 1998, 72, 943-949
19. Stevenson P.G., Belz G.T., Castrucci M.R., Altman J.D., Doherty P.C., A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lyticphase epitope, Proc. Natl. Acad. Sci. USA, 1999, 96, 9281-9286
20. Usherwood E.J., Ross A.J., Allen D.J., Nash A.A., Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cells, J. Gen. Virol., 1996, 77, 627-630
21. Stevenson P.G., Efstathiou S., Doherty P.C., Lehner P.J., Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses, Proc. Natl. Acad. Sci. USA, 2000, 97, 8455-8460
22. Belz G.T., Doherty P.C., Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection, J. Virol., 2001, 75, 4435-4438
23. Woodland D.L., Flano E., Usherwood E.J., Liu L., Kim I.J., Husain S.M., et al., Antigen expression during murine gamma-herpesvirus infection, Immunobiology, 2001, 204, 649-658
24. Blackman M.A., Flano E., Usherwood E., Woodland D.L., Murine gamma-herpesvirus-68: a mouse model for IM?, Mol. Med. Today, 2000, 6, 488-490
25. Mistríková J., Remeňová A., Leššo J., Stančeková M., Replication and persistence of murine herpesvirus 72 in lymphatic system and peripheral blood mononuclear cells of Balb/C mice, Acta Virol., 1994, 38, 151-156
26. Rašlová H., Mistríková J., Kúdelová M., Mishal Z., Sarasin A., Blangy D., et al., Immunophenotypic study of atypical lymphocytes generated in peripheral blood and spleen of nude mice after MHV-72 inoculation, Viral Immunol., 2000, 13, 313-327
27. Hricová M., Mistríková J., Ecological characterization and epidemiological implication of the murine herpesvirus 68, Biologia, 2007 (submitted)
28. Mrmusova M., Horvathova M., Klobusicka M., Mistrikova J., Immunophenotyping of leukocytes in peripheral blood of BALB/c mice infected with mouse herpesvirus isolate 72, Acta Virol., 2002, 46, 19-24
29. Mistríková J., Mrmusová M., Detection of abnormal lymphocytes in the blood of Balb/c mice infected with murine gammaherpesvirus strain 72: the analogy with Epstein-Barr virus infection, Acta Virol., 1998, 42, 79-82
30. Sunil-Chandra N.P., Arno J., Fazakerly J., Nash A.A., Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68, Am. J. Pathol., 1994, 145, 818-826
31. Mistriková J., Rajčáni J., Mrmusová M., Oravcová I., Chronic infection of Balb/c mice with murine herpesvirus 72 is associated with neoplasm development, Acta Virol., 1996, 40, 297-301.
32. Mistríková J., Mrmusová M., Ďurmanová V., Rajčáni J., Increased neoplasm development due to immunosuppressive treatment with FK-506 in BALB/C mice persistently infected with the mouse herpesvirus (MHV-72), Viral Immunol., 1999, 12, 237-247
33. Oda W., Mistriková J., Stančeková M., Dutia B.M., Basah A.A., Takahata H., et al., Analysis of genomic homology of murine gammaherpesvirus MHV-72 to MHV-68 and impact of the survival and tumorigenesis in the MHV-72-infected CB17 scid/scid and CB17+/+ mice, Pathol. Int., 2005, 55, 558-568
34. Mistríková J., Blaškovičová J., Pappová M., Hricová M., Establishment and characterization of a tumor cell line derived from a mouse infected with murine gammaherpesviurs 78, Acta Virol., 2006, 50, 223-227
35. Usherwood E.J., Stewart J.P., Nash A.A., Characterization of tumor cell lines derived from murine gammaherpevirus-68-infected cells, J. Virol., 1996, 70, 6516-6518
36. Tarakanova V.L., Suarez F., Tibbetts S.A., Jacoby M.A., Weck K.E., Hess J.L., et al., Murine gmmaherpesvirus 68 infection is Associated with lymphoroliferative disease and lymophioma in Balb/c b2 microglobulin-deficient mice, J. Virol., 2005, 79, 14668-14679
37. Rašlová H., Berebbi M., Rajčáni J., Sarasin A., Matis J., Kúdelová M., Susceptibility of mouse mammary glands to murine gammaherpesvirus 72 (MHV-72) infection: evidence of MHV-72 transmission via breast milk, Microb. Pathog., 2001, 31, 47-58
38. Mistriková J., Mrmusová-Šupolíková M., Rajčáni J., Leukemia-like syndrome in Balb/c mice infected with the lymphotropic gamma herpesvirus MHVŠumava: an analogy to EBV infection, Neoplasma, 2004, 51, 71-76
39. Mrmusová-Šupolíková M., Pappová M., Mistríková J., Pathogenesis of murine lymphotropic gammaherpesvirus isolate 78, Acta Veter. Brno, 2003, 72, 371-376
40. Pappová M., Stančeková M., Spišš áková I., Ďurmanová V., Mistríková J., Pathogenetical characterization of isolate MHV-60 of mouse herpesvirus, Acta Virol., 2004, 48, 1-11
41. Chalupková A., Hricová M., Hrabovská Z., Mistríková J., Pathogenetical characterization of MHV-76: a spontaneous 9.5 kbp deletion mutant of MuHV-4, Acta Vet. Brno, 2008 (accepted)
42. Macrae A.I., Dutia B., Milligan S., Brownstein D., Allen D.J., Mistrikova J., et al., Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis, J. Virol., 2001, 75, 5315-5327
43. Rajčáni J., Kúdelová M., Murine herpesvirus pathogenesis: a model for the analysis of molecular mechanisms of human gammaherpesvirus infection, Acta Microbiol. Immunol. Hung., 2005, 52, 41-71
44. Virgin H.W., Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., et al., Complete sequence and genomic analysis of murine gammaherpesvirus 68, J. Virol., 1997, 71, 5894-5904
45. Bowden R.J., Simas J.P., Davis A.J., Efstathiou S., Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency, J. Gen. Virol., 1997, 78, 1675-1687
46. Simas J.P., Bowden R.J., Palge V., Efstathiou S., Four tRNA like sequences and a serpin homologue encoded by murine gammaherpevirus are dispensable for lytic replication in vitro and latency in vivo, J. Gen. Virol., 1998, 79, 149-153
47. Simas J.P., Swann D., Bowden R., Efstathiou S., Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection, J. Gen. Virol., 1999, 80, 75-82
48. Tugwood J.D., Lau W.H., Tsao S.Y., Martin W.M., Shiu W., Desgranges C., et al., Epstein-Barr virusspecific transcription in normal and malignant nasopharyngeal biopsies and in lymphocytes from healthy donors and IM patients, J. Gen. Virol., 1987, 68, 1081-1091
49. Pfeffer S., Sewer A., Quintana M.L., Sheridan R., Sander Ch., Gässer F.A., et al., Identification of microRNAs of the herpesvirus family, Nature Methods, 2005, 2, 269-276
50. Valovičová M., Belvončíková P., Halasová Z., Rajčáni J., Kúdelová M., Mapping of the left end of murine herpesvirus 72 (MHV-72) genome, Acta Microbiol. Immunol. Hung., 2007, 54, 138-139
51. Clambey E.T., Virgin H.W., Speck S.H., Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency, J. Virol., 2002, 76, 6532-6544
52. Blaškovičová J., Tomášková J., Šupolíková M., Mistríková J., Kopáček J., Unique deletion identified in the genomic region encompassing the terminal repeats of Murid herpesvirus 4 (MuHV 4), isolate Šumava, Acta Virol., 51, 143-148
53. Komiyama T., Ray C.A., Pickup D.J., Howard A.D., Thornberry N.A., Peterson E.P., et al., Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition, J. Biol. Chem., 1994, 269, 19331-19337
54. Clambey E.T., Virgin H.W., Speck S.H., Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency, J. Virol., 2000, 74, 1973-1984
55. Virgin H.W., Presti R.M., Li X.Y., Liu C., Speck S.H., Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice, J. Virol., 1999, 73, 2321-2332
56. Husain S.M., Usherwood E.J., Dyson H., Coleclough C., Coppola M.A., Woodland D.L., et al., Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8(+) T lymphocytes, Proc. Natl. Acad. Sci. USA, 1999, 96, 7508-7513
57. Macrae A.I., Usherwood E.J., Husein S.M., Murid herpesvirus strain 68 M2 protein is a B cell associated antigen important for latency but not lymphocytosis, J. Virol., 2003, 77, 9700-9709
58. Liang X., Shin Y.C., Means R.E., Jung J.U., Inhibition of interferon-mediated antiviral activity by murine gammaherpesvirus 68 latency-associated M2 protein, J. Virol., 2004, 78, 12416-12427
59. Usherwood E.J., Ward K.A., Blackman M.A., Stewart J.P., Woodland D.L., Latent antigen vaccination in a model gammaherpesvirus infection, J. Virol., 2001, 75, 8283-8288
60. Jacoby M.A., Virgin H.W., Speck S.H., Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation, J. Virol., 2002, 76, 1790-1801
61. Bridgeman A., Stevenson P.G., Simas J.P., Efstathiou S., A secreted chemokine binding protein encoded by murine gammaherpesvirus 68 is necessary for the establishment of a normal latent load, J. Exp. Med., 1997, 194, 301-312
62. van Berkel V., Preiter K., Virgin H.W., Speck S.H., Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein, J. Virol., 1999, 73, 4524-4529
63. Parry C.M., Simas J.P., Smith V.P., Stewart C.A., Minson A.C., Efstathiou S., et al., A broad spectrum secreted chemokine binding protein encoded by a herpesvirus, J. Exp. Med., 2000, 191, 573-578
64. Sarawar S.R., Lee B.J., Anderson M., Teng Y.C., Zuberi R., Von Gesjen S., Chemokine induction and leukocyte trafficking to the lungs during murine gammaherpesvirus 68 (MHV-68) infection, Virology, 2002, 293, 54-62
65. Alcami A., Structural basis of the herpesvirus M3-chemokine interaction, Trends Microbiol., 2003, 11, 191-192
66. Obar J.J., Donovan D.C., Crist S.G., Silvia O., Stewart J.P., Usherwood E.J., T-cell responses to the M3 immune evasion protein of murid gammaherpesvirus 68 are partially protective and induced with lytic antigen kinetics, J. Virol., 2004, 78, 10829-10832
67. Townsley A.C., Dutia B. M., Nash A.A., The m4 gene of murine gammaherpesvirus modulates productive and latent infection in vivo, J. Virol., 2004, 78, 758-767
68. H.M. Geere, Y. Ligertwood, K.M. Templeton, I. Bennet, B. Gandagharan, Rhind S.M., et al., The M4 gene of murine gammaherpesvirus 68 modulates latent infection, J. Gen. Virol., 2006, 87, 803-807
69. vanBerkel V., Levine B., Kapadia S.B., Goldman J.E., Speck S.H., Virgin H.V., Clinical role for a high affinity chemokine binding protein g-herpesvirus induced lethal meningitis, J. Clin. Invest., 2002, 109, 905-914
70. Evans A.G., Moorman N.J., Willer D.O., Speck S.H., The M4 gene of gHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency, Virology, 2006, 344, 520-531
71. Rajčáni J., Kúdelová M., Gammaherpesviruses: pathogenesis of infection and cell signalling, Folia Microbiol. (Praha), 2003, 48, 291-318
72. Dutia B.M., Roy D.J., Ebrahimi B., Gangadharan B., Efstathiou S., Stewart J.P., et al., Identification of a region of the virus genome involved in murine gammaherpesvirus 68-induced splenic pathology, J. Gen. Virol., 2004, 85, 1393-1400
73. Nevins J.R., Cell transformation by viruses, In: Fields Virology 4th Ed., vol.1, Lippincott Williams and Wilkins, Philadelphia, 2001, 245-283
74. Kúdelová M., Rajčáni J., Gammaherpesviruses and oncogenesis, In: L.T. Johannes (Ed.) Oncogenic Viruses Research Trends, Nova Science Publishers, 2007, 102-136
75. Sunil-Chandra N.P., Arno J., Fazakerley J., Nash A.A., Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68, Am. J. Pathol., 1994, 145, 818-826
76. Mistríková J., Moško T., Mrmusová M., Pathogenic characterization of a mouse herpesvirus isolate Šumava, Acta Virol., 2002, 46, 41-46