Effect of temperature on the chromatographic retention of ionizable compounds. III. Modeling retention of Pharmaceuticals as a function of eluent pH and column temperature in RPLC

Journal of Separation Science

Volumn 31, Issue 6-7, 2008, Pages 969-980

  Gagliardi, Leonardo G ^a   Castells, Cecilia B ^a   Ràfols, Clara ^b   Rosés, Martí ^b   Bosch, Elisabeth ^b  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Column temperature; Ionizable solutes; Predictive model; Profens, blockers, alkaloids

Indexed keywords

DRUG PRODUCTS; ENTHALPY; PH EFFECTS; SOLVENTS; THERMAL EFFECTS; THERMODYNAMICS;

ALKALOIDS; COLUMN TEMPERATURE; IONIZABLE SOLUTES; PREDICTIVE MODEL; PROFENS;

CHROMATOGRAPHIC ANALYSIS;

ACEBUTOLOL; ACETIC ACID; ARYLPROPIONIC ACID DERIVATIVE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUFFER; BUTYLAMINE; CARBOXYLIC ACID DERIVATIVE; CINCHONA ALKALOID; CINCHONIDINE; CINCHONINE; DISODIUM HYDROGEN PHOSPHATE; FENBUFEN; HYDROCHLORIC ACID; KETOPROFEN; METOPROLOL; OXPRENOLOL; PHENYLSUCCINIC ACID; PHOSPHORIC ACID; PINDOLOL; PIPERAZINE; POTASSIUM DIHYDROGEN PHOSPHATE; PROPRANOLOL; QUINIDINE; QUININE; SUPROFEN; TROMETAMOL;

ACID BASE BALANCE; ACIDITY; ALKALINITY; ARTICLE; COLUMN CHROMATOGRAPHY; COMPARATIVE STUDY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DETERMINATION; DRUG STRUCTURE; ENTHALPY; EXPERIMENTAL MODEL; HYDROPHOBICITY; IONIZATION; PH MEASUREMENT; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLUTE; SOLVENT EFFECT; TEMPERATURE SENSITIVITY; THEORETICAL MODEL; THERMODYNAMICS;

BUFFERS; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; IONS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; SOLUTIONS; TEMPERATURE;

EID: 43249099564     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700491     Document Type: Article

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