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1
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0021636059
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The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients
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Stoutenbeek CP, van Saene HKF, Miranda DR, Zandstra DF. The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients. Intensive Care Med 1984; 10:185-192.
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Stoutenbeek, C.P.1
van Saene, H.K.F.2
Miranda, D.R.3
Zandstra, D.F.4
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2
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33846857165
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Stoutenbeek CP, van Saene HK, Little RA, Whitehead A. The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial. Intensive Care Med 2007; 33:261-270. This was the largest randomized multicenter study of SDD in trauma patients with 401 patients included, between 1991 and 1994. Overall mortality rates were 20.9% in patients with SDD and 22.0% in controls.
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Stoutenbeek CP, van Saene HK, Little RA, Whitehead A. The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial. Intensive Care Med 2007; 33:261-270. This was the largest randomized multicenter study of SDD in trauma patients with 401 patients included, between 1991 and 1994. Overall mortality rates were 20.9% in patients with SDD and 22.0% in controls.
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3
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33847043499
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Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials
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Silvestri L, van Saene HK, Milanese M, et al. Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect 2007; 65:187-203.
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Silvestri, L.1
van Saene, H.K.2
Milanese, M.3
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4
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0037108543
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Krueger WA, Lenhart FP, Neeser G, et al. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind. placebo-controlled clinical trial. Am J Respir Crit Care Med 2002; 166:1029-1037.
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Krueger WA, Lenhart FP, Neeser G, et al. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind. placebo-controlled clinical trial. Am J Respir Crit Care Med 2002; 166:1029-1037.
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5
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0141537234
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Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomized controlled trial
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de Jonge E, Schultz M, Spanjaard L, et al. Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomized controlled trial. Lancet 2003; 362:1011-1016.
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de Jonge, E.1
Schultz, M.2
Spanjaard, L.3
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6
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14544285137
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Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: A randomized, placebo-controlled, double-blind trial
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de la Cal MA, Cerda E, Garcia-Hierro P, et al. Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial. Ann Surg 2005; 241:424-430.
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de la Cal, M.A.1
Cerda, E.2
Garcia-Hierro, P.3
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7
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20344399772
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Impact of selective decontamination of the digestive tracton fungal carriage and infection: Systematic review of randomized controlled trials
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Silvestri L, van Saene HK, Milanese M, Gregori D. Impact of selective decontamination of the digestive tracton fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med 2005; 31:898-910.
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Silvestri, L.1
van Saene, H.K.2
Milanese, M.3
Gregori, D.4
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8
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34948888187
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Treatment outcome of selective digestive decontamination and enteral nutrition in patients with severe acute pancreatitis
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Sawa H, Ueda T, Takeyama Y, et al. Treatment outcome of selective digestive decontamination and enteral nutrition in patients with severe acute pancreatitis. J Hepatobiliary Pancreat Surg 2007; 14:503-508.
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Sawa, H.1
Ueda, T.2
Takeyama, Y.3
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9
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0029021395
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Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis
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Luiten EJT, Hop WCJ, Lange JF, Bruining HA. Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann Surg 1995; 222:57-65.
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Luiten, E.J.T.1
Hop, W.C.J.2
Lange, J.F.3
Bruining, H.A.4
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10
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34247630083
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Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterology 2007; 132:2022-2044.
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Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterology 2007; 132:2022-2044.
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11
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31144470092
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The role of selective decontamination of the digestive tract in acute stroke
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Gosney M, Martin MV, Wright AE. The role of selective decontamination of the digestive tract in acute stroke. Age Ageing 2006; 35:42-47.
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(2006)
Age Ageing
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Gosney, M.1
Martin, M.V.2
Wright, A.E.3
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12
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33747627879
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Selective digestive tract decontamination-will it prevent infection with multidrug-resistant gram-negative pathogens but still be applicable in institutions where methicillin-resistant Staphylococcus aureus and vancomy-cin-resistant enterococci areendemic?
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Bonten MJ. Selective digestive tract decontamination-will it prevent infection with multidrug-resistant gram-negative pathogens but still be applicable in institutions where methicillin-resistant Staphylococcus aureus and vancomy-cin-resistant enterococci areendemic? Clin Infect Dis 2006;43(Suppl 2):S70-S74.
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Clin Infect Dis
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Bonten, M.J.1
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13
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0033835550
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Selective digestive decontamination in patients in intensive care
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Bonten MJM, Kullberg BJ, Dalen Rv, et al. Selective digestive decontamination in patients in intensive care. J Antimicrob Chemother 2000; 46:351-362.
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Bonten, M.J.M.1
Kullberg, B.J.2
Dalen, R.3
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14
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33745922525
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Heininger A, Meyer E, Schwab F, et al. Effects of long-term routine use of selective digestive decontamination on antimicrobial resistance. Intensive Care Med 2006; 32:1569-1576. This presents a longitudinal analysis of antibiotic resistance trends in a German ICU using SDD, as compared to resistance trends in other German ICUs not using SDD. Rates of MRSA did not increase in the SDD unit, and were, on average, lower than in the non-SDD units. In the SDD unit, however, patients were screened for MRSA carriage and treated in strict isolation when being colonized.
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Heininger A, Meyer E, Schwab F, et al. Effects of long-term routine use of selective digestive decontamination on antimicrobial resistance. Intensive Care Med 2006; 32:1569-1576. This presents a longitudinal analysis of antibiotic resistance trends in a German ICU using SDD, as compared to resistance trends in other German ICUs not using SDD. Rates of MRSA did not increase in the SDD unit, and were, on average, lower than in the non-SDD units. In the SDD unit, however, patients were screened for MRSA carriage and treated in strict isolation when being colonized.
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15
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33748702672
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Emergence of multidrug-resistant Gramnegative bacteria during selective decontamination of the digestive tract on an intensive care unit
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Al NN, Heddema ER, Bart A, et al. Emergence of multidrug-resistant Gramnegative bacteria during selective decontamination of the digestive tract on an intensive care unit. J Antimicrob Chemother 2006; 58:853-856.
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J Antimicrob Chemother
, vol.58
, pp. 853-856
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NN, A.1
Heddema, E.R.2
Bart, A.3
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16
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0031878768
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Changing bacterial ecology during a five year period of selective intestinal decontamination
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Lingnau W, Berger J, Javorsky F, et al. Changing bacterial ecology during a five year period of selective intestinal decontamination. J Hosp Infect 1998; 39:195-206.
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J Hosp Infect
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Lingnau, W.1
Berger, J.2
Javorsky, F.3
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17
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34247619942
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Cerda E, Abella A, de la Cal MA, et al. Enteral vancomycin controls methicillin-resistant Staphylococcus aureus endemicity in an intensive care burn unit: a 9-year prospective study. Ann Surg 2007; 245:397-407. The authors conducted a before-after comparison of MRSA epidemiology in a Spanish burn unit. In the first period SDD was prescribed to a subset of patients (as part of a randomized study (see de la Cal et al. [6]), and thereafter all patients received SDD with topical vancomcyin added. The number of patients colonized with MRSA on admission and number of MRSA-acquisition reduced in the second period. These are challenging findings on the association between SDD and MRSA and the potential role of vancomycin in controlling antibiotic resistance.
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Cerda E, Abella A, de la Cal MA, et al. Enteral vancomycin controls methicillin-resistant Staphylococcus aureus endemicity in an intensive care burn unit: a 9-year prospective study. Ann Surg 2007; 245:397-407. The authors conducted a before-after comparison of MRSA epidemiology in a Spanish burn unit. In the first period SDD was prescribed to a subset of patients (as part of a randomized study (see de la Cal et al. [6]), and thereafter all patients received SDD with topical vancomcyin added. The number of patients colonized with MRSA on admission and number of MRSA-acquisition reduced in the second period. These are challenging findings on the association between SDD and MRSA and the potential role of vancomycin in controlling antibiotic resistance.
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18
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33747607290
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Potential confounding in evaluating infection-control interventions in hospital settings: Changing antibiotic prescription
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Nijssen S, Bootsma M, Bonten M. Potential confounding in evaluating infection-control interventions in hospital settings: changing antibiotic prescription. Clin Infect Dis 2006; 43:616-623.
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Clin Infect Dis
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Nijssen, S.1
Bootsma, M.2
Bonten, M.3
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19
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34848916374
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Statistical analysis and application of quasi experiments to antimicrobial resistance intervention studies
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Shardell M, Harris AD, El-Kamary SS, et al. Statistical analysis and application of quasi experiments to antimicrobial resistance intervention studies. Clin Infect Dis 2007; 45:901-907.
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Clin Infect Dis
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Shardell, M.1
Harris, A.D.2
El-Kamary, S.S.3
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20
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35448977372
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Accumulation of oral antibiotics as an adverse effect of selective decontamination of the digestive tract: A series of three cases
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Smit MJ, van der Spoel JI, de Smet AM, et al. Accumulation of oral antibiotics as an adverse effect of selective decontamination of the digestive tract: a series of three cases. Intensive Care Med 2007; 33:2025-2026.
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Smit, M.J.1
van der Spoel, J.I.2
de Smet, A.M.3
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21
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0035422606
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Prevention of ventilator-associated pneumonia by oral decontamination: A prospective, randomized, double-blind, placebo-controlled study
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Bergmans DC, Bonten MJ, Gaillard CA, et al. Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001; 164:382-388.
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Bergmans, D.C.1
Bonten, M.J.2
Gaillard, C.A.3
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22
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0025863441
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Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: A randomized, placebo-controlled, double-blind clinical trial
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Pugin J, Auckenthaler R, Lew DP, Suter PM. Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: a randomized, placebo-controlled, double-blind clinical trial. J Am Med Assoc 1991; 265: 2704-2710.
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Pugin, J.1
Auckenthaler, R.2
Lew, D.P.3
Suter, P.M.4
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23
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30344462677
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A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia
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This describes a large randomized double-blind placebo-controlled trial on the effects of an oral paste with an in-vitro antimicrobial protein in a mixed ICU-population. Yet, in vivo, the application had only minor effects on oropharyngeal colonization and did not prevent the development of VAP
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Kollef M, Pittet D, Sanchez GM, et al. A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 2006; 173:91-97. This describes a large randomized double-blind placebo-controlled trial on the effects of an oral paste with an in-vitro antimicrobial protein in a mixed ICU-population. Yet, in vivo, the application had only minor effects on oropharyngeal colonization and did not prevent the development of VAP.
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Am J Respir Crit Care Med
, vol.173
, pp. 91-97
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Kollef, M.1
Pittet, D.2
Sanchez, G.M.3
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24
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0033948397
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IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis
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Mosca DA, Hurst MA, So W, et al. IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis. Antimicrob Agents Chemother 2000; 44:1803-1808.
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Mosca, D.A.1
Hurst, M.A.2
So, W.3
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25
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33745132106
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Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia
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This was a randomized double-blind placebo-controlled multicenter trial on the effects of an oral paste with either chlorhexidine (2, or chlorhexidine (2, with colistin 2, in a mixed ICU population. Both pastes reduced oropharyngeal colonization and were associated with a significant reduction of VAP
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Koeman M, van der Ven AJ, Hak E, et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 2006; 173:1348-1355. This was a randomized double-blind placebo-controlled multicenter trial on the effects of an oral paste with either chlorhexidine (2%) or chlorhexidine (2%) with colistin (2%) in a mixed ICU population. Both pastes reduced oropharyngeal colonization and were associated with a significant reduction of VAP.
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Am J Respir Crit Care Med
, vol.173
, pp. 1348-1355
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Koeman, M.1
van der Ven, A.J.2
Hak, E.3
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26
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33751229919
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Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: A randomized controlled trial
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This was a large randomized trial on the effects of an oral paste with chlorhexidine 0.12, in a cardiosurgical population. Chlorhexidine decontamination was associated with a significant reduction of respiratory tract infections and wound infections
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Segers P, Speekenbrink RG, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA 2006; 296:2460-2466. This was a large randomized trial on the effects of an oral paste with chlorhexidine (0.12%) in a cardiosurgical population. Chlorhexidine decontamination was associated with a significant reduction of respiratory tract infections and wound infections.
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(2006)
JAMA
, vol.296
, pp. 2460-2466
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Segers, P.1
Speekenbrink, R.G.2
Ubbink, D.T.3
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27
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23844508830
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Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: A double-blind placebo-controlled multicenter study
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Fourrier F, Dubois D, Pronnier P, et al. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study. Crit Care Med 2005; 33:1728-1735.
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Fourrier, F.1
Dubois, D.2
Pronnier, P.3
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28
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34247882117
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Oral decontamination for prevention of pneumonia in mechanically ventilated adults: Systematic review and metaanalysis
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Chan EY, Ruest A, Meade MO, Cook DJ. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and metaanalysis. BMJ 2007; 334:889-900.
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BMJ
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Chan, E.Y.1
Ruest, A.2
Meade, M.O.3
Cook, D.J.4
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