Using genetically modified microvascular free flaps to deliver local cancer immunotherapy with minimal systemic toxicity

Plastic and Reconstructive Surgery

Volumn 121, Issue 5, 2008, Pages 1541-1553

  Dempsey, Marlese P ^a   Hamou, Cynthia ^a   Michaels V, Joseph ^a   Ghali, Shadi ^a   Jazayeri, Leila ^a   Grogan, Raymon H ^a   Gurtner, Geoffrey C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CD8 ANTIGEN; CHORIONIC GONADOTROPIN BETA SUBUNIT; GAMMA INTERFERON; INTERLEUKIN 12; LIVER ENZYME; VIRUS VECTOR;

ANASTOMOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; DNA MODIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO GENE TRANSFER; FEMALE; FISCHER 344 RAT; FREE TISSUE GRAFT; INFLAMMATION; LIVER HISTOLOGY; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN; SUPERFICIAL INFERIOR EPIGASTRIC ARTERY FLAP; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; DRUG DELIVERY SYSTEMS; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOTHERAPY; INTERLEUKIN-12; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MALE; MICROCIRCULATION; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RATS; RATS, INBRED F344; SURGICAL FLAPS;

EID: 43149098509     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e31816ff6aa     Document Type: Article

References (41)

1. Parish, C. R. Cancer immunotherapy: The past, the present and the future. Immunol. Cell Biol. 81: 106, 2003.
2. Chada, S., Ramesh, R., and Mhashilkar, A. M. Cytokine- and chemokine-based gene therapy for cancer. Curr. Opin. Mol. Ther. 5: 463, 2003.
3. Lamont, A. G., and Adorini, L. IL-12: A key cytokine in immune regulation. Immunol. Today 17: 214, 1996.
4. Qian, C., Liu, X. Y., and Prieto, J. Therapy of cancer by cytokines mediated by gene therapy approach. Cell Res. 16: 182, 2006.
5. Brunda, M., Luistro, L., Warrier, R. R., et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178: 1223, 1993.
6. Noguchi, Y., Jungbluth, A., Richards, E. C., and Old, L. J. Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc. Natl. Acad. Sci. U.S.A. 93: 11798, 1996.
7. Nanni, P., Nicoletti, G., De Giovanni, C., et al. Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J. Exp. Med. 194: 1195, 2001.
8. Colombo, M. P., and Trinchieri, G. Interleukin-12 in antitumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13: 155, 2002.
9. Trinchieri, G. Interleukin-12: A cytokine at the interface of inflammation and immunity. Adv. Immunol. 70: 83, 1998.
10. Kobayashi, M., Fitz, L., Ryan, M., et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827, 1989.
11. Gee, M., Saunders, H. M., Lee, J. C., et al. Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations. Cancer Res. 61: 2974, 2001.
12. Voest, E., Kenyon, B. M., O'Reilly, M. S., Truitt, G., D'Amato, R. J., and Folkman, J. Inhibition of angiogenesis in vivo by interleukin 12. J. Natl. Cancer Inst. 87: 581, 1995.
13. Yao, L., Pike, S. E., Setsuda, J., et al. Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12. Blood 96: 1900, 2000.
14. Brunetti-Pierri, N., Palmer, D. J., Beaudet, A. L., Carey, K. D., Finegold, M., and Ng, P. Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum. Gene Ther. 15: 35, 2004.
15. Sung, M., Chen, S. H., Thung, S. M., et al. Intratumoral delivery of adenovirus-mediated interleukin-12 gene in mice with metastatic cancer in the liver. Hum. Gene Ther. 13: 731, 2002.
16. Portielje, J. E., Gratama, J. W., van Ojik, H. H., Stoter, G., and Kruit, W. H. IL-12: A promising adjuvant for cancer vaccination. Cancer Immunol. Immunother. 52: 133, 2003.
17. Michaels, J. T., Dobransky, M., Galiano, R. D., et al. Ex vivo transduction of microvascular free flaps for localized peptide delivery. Ann. Plast. Surg. 52: 581, 2004.
18. Michaels, J., Levine J. P., Hazen, A., et al. Biologic brachytherapy: Ex vivo transduction of microvascular beds for efficient, targeted gene therapy. Plast. Reconstr. Surg. 118:54, 2006.
19. Shih, I., Torrance, C., Sokoll, L. J., Chan, D. W., Kinzler, K. W., and Vogelstein, B. Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin. Nat. Med. 6: 711, 2000.
20. Zhang, F., Sones, W. D., and Lineaweaver, W. C. Microsurgical flap models in the rat. J. Reconstr. Microsurg. 17: 211, 2001.
21. Gregorevic, P., Blankinship, M. J., Allen, J. M., et al. Systemic delivery of genes to striated muscles using adeno-associated viral vectors. Nat. Med. 10: 828, 2004.
22. Feral, C., Nishiya, N., Fenczik, C. A., Stuhlmann, H., Slepak, M., and Ginsberg, M. H. CD98hc (SLC3A2) mediates integrin signaling. Proc. Natl. Acad. Sci. U.S.A. 102: 355, 2005.
23. Cox, C., Merajver, S. D., Yoo, S., et al. Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced copper suppression in a murine model. Arch. Otolaryngol. Head Neck Surg. 129: 781, 2003.
24. Lyngstadaas, A. Status and potential of gene therapy in clinical medicine: Assessment of an emerging health technology through systematic survey of clinical gene therapy protocols and published results. Int. J. Technol. Assess. Health Care 18: 645, 2002.
25. Verma, I. M., and Weitzman, M. D. Gene therapy: Twenty-first century medicine. Annu. Rev. Biochem. 74: 711, 2005.
26. Gottesman, M. M. Cancer gene therapy: An awkward adolescence. Cancer Gene Ther. 10: 501, 2003.
27. Baranowski, E., Ruiz-Jarabo, C. M., and Domingo, E. Evolution of cell recognition by viruses. Science 292: 1102, 2001.
28. Brown, B. D., and Lillicrap, D. Dangerous liaisons: The role of "danger" signals in the immune response to gene therapy. Blood 100: 1133, 2002.
29. Bowers, W. J., Olschowka, J. A., and Federoff, H. J. Immune responses to replication-defective HSV-1 type vectors within the CNS: Implications for gene therapy. Gene Ther. 10: 941, 2003.
30. Chen, D., Murphy, B., Sung, R., and Bromberg, J. S. Adaptive and innate immune responses to gene transfer vectors: Role of cytokines and chemokines in vector function. Gene Ther. 10: 991, 2003.
31. Jooss, K., and Chirmule, N. Immunity to adenovirus and adeno-associated viral vectors: Implications for gene therapy. Gene Ther. 10: 955, 2003.
32. Lowenstein, P. R. Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses. Gene Ther. 10: 933, 2003.
33. Gajewski, T. F., Fallarino, F., Ashikari, A., and Sherman, M. Immunization of HLA-A2+- melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin. Cancer Res. 7: 895s, 2001).
34. Lee, P., Wang, F., Kuniyoshi, J., et al. Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma. J. Clin. Oncol. 19: 3836, 2001.
35. Crystal, R. G. Transfer of genes to humans: Early lessons and obstacles to success. Science 270: 404, 1995.
36. Alemany, R., Balague, C., and Curiel, D. T. Replicative adenoviruses for cancer therapy. Nat. Biotechnol. 18: 723, 2000.
37. Leonard, J., Sherman, M. L., Fisher, G. L., et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 90: 2541, 1997.
38. Wang, Y., Liu, S., Li, C. Y., and Yuan, F. A novel method for viral gene delivery in solid tumors. Cancer Res. 65: 7541, 2005.
39. Wang, Y., Hu, J. K., Krol, A., Li, Y. P., Li, C. Y., and Yuan, F. Systemic dissemination of viral vectors during intratumoral injection. Mol. Cancer Ther. 2: 1233, 2003.
40. Hurvitz, K. A., Kobayashi, M., and Evans, G. R. Current options in head and neck reconstruction. Plast. Reconstr. Surg. 118: 122e, 2006.
41. Serletti, J. M. Breast reconstruction with the TRAM flap: Pedicled and free. J. Surg. Oncol. 94: 532, 2006.