Current options in head and neck reconstruction

Plastic and Reconstructive Surgery

Volumn 118, Issue 5, 2006, Pages

  Hurvitz, Keith A ^a   Kobayashi, Mark ^a   Evans, Gregory R D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER SURGERY; CRANIOCERVICOFACIAL DEFECT; DIGESTIVE SYSTEM; ESTHETIC SURGERY; FACE MALFORMATION; FIBULA; FOREARM; FREE TISSUE GRAFT; HEAD AND NECK CANCER; HEAD AND NECK MALFORMATION; HEAD AND NECK RECONSTRUCTION; HEAD AND NECK SURGERY; HUMAN; JAW MALFORMATION; PLASTIC SURGERY; PRIORITY JOURNAL; RECTUS ABDOMINIS MUSCLE; SKIN DEFECT; SKIN TRANSPLANTATION; SKULL BASE FRACTURE; SKULL DEFECT; SOFT TISSUE DEFECT; SURGICAL TECHNIQUE; THIGH; TISSUE TRANSPLANTATION; TREATMENT OUTCOME;

FORECASTING; HEAD; HEAD AND NECK NEOPLASMS; HUMANS; MANDIBLE; NECK; OSTEOGENESIS, DISTRACTION; RECONSTRUCTIVE SURGICAL PROCEDURES; SCALP; SKIN TRANSPLANTATION; SKULL BASE; SOFT TISSUE INJURIES; SURGICAL FLAPS; TONGUE;

EID: 33749448034     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000237094.58891.fb     Document Type: Article

References (116)

1. Gurtner, G. C., and Evans, G. R. Advances in head and neck reconstruction. Plast. Reconstr. Surg. 106: 672, 2000.
2. Thompson, J., Scolyer, R., and Kefford, R. Cutaneous melanoma. Lancet 365: 687, 2005.
3. Blair, E. A., and Callender, D. L. Head and neck cancer: The problem. Clin. Plast. Surg. 21: 1, 1994.
4. Silverberg, E., Boring, C. C., and Squires, T. S. Cancer statistics, 1990. CA Cancer J. Clin. 40: 9, 1990.
5. Lang, P. G., Jr. The role of Mohs' micrographic surgery in the management of skin cancer and a perspective on the management of the surgical defect. Clin. Plast. Surg. 31: 5, 2004.
6. Andry, G., Hamoir, M., and Leemans, C. R. The evolving role of surgery in the management of head and neck tumors. Curr. Opin. Oncol. 17: 241, 2005.
7. Davis, R. K., Hadley, K., and Smith, M. E. Endoscopic vertical partial laryngectomy. Laryngoscope 114: 236, 2004.
8. de Campora, E., Radici, M., and de Campora, L. External versus endoscopic approach in the surgical treatment of glottic cancer. Eur. Arch. Otorhinolaryngol. 258: 533, 2001.
9. Moyer, J. S., Wolf, G. T., and Bradford, C. R. Current thoughts on the role of chemotherapy and radiation in advanced head and neck cancer. Curr. Opin. Otolaryngol. Head Neck Surg. 12: 82, 2004.
10. Urba, S. G., Moon, J., Giri, P. G., et al. Organ preservation for advanced resectable cancer of the base of tongue and hypopharynx: A Southwest Oncology Group Trial. J. Clin. Oncol. 23: 88, 2005.
11. Laramore, G. E., and Coltrera, M. D. Organ preservation strategies in the treatment of laryngeal cancer. Curr. Treat. Options Oncol. 4: 15, 2003.
12. Hoffmann, T. K., Bier, H., and Whiteside, T. L. Targeting the immune system: Novel therapeutic approaches in squamous cell carcinoma of the head and neck. Cancer Immunol. Immunother. 53: 1055, 2004.
13. Harrington, K. J., Nutting, C. M, and Pandha, H. S. Gene therapy for head and neck cancer. Cancer Metastasis Rev. 24: 147, 2005.
14. Balz, V., Scheckenbach, K., Gotte, K., Bockmuhl, U., Petersen, I., and Bier, H. Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens. Cancer Res. 63: 1188, 2003.
15. Ariyan, S., Ross, D. A., and Sasaki, C. T. Reconstruction of the head and neck. Surg. Oncol. Clin. N. Am. 6: 1, 1997.
16. Nabawi, A., Gurlek, A., Patrick, C. W., Jr., et al. Measurement of blood flow and oxygen tension in adjacent tissues in pedicled and free flap head and neck reconstruction. Microsurgery 19: 254, 1999.
17. Blackwell, K. E., Buchbinder, D., Biller, H. F., and Urken, M. L. Reconstruction of massive defects in the head and neck: The role of simultaneous distant and regional flaps. Head Neck 19: 620, 1997.
18. Foster, R. D., Anthony, J. P., Sharma, A., and Pogrel, M. A. Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: An outcome analysis of primary bony union and endosseous implant success. Head Neck 21: 66, 1999.
19. Villarreal, P. M., Monje, F., Morillo, A. J., Junquera, L. M., Gonzalez, C., and Barbon, J. J. Porous polyethylene implants in orbital floor reconstruction. Plast. Reconstr. Surg. 109: 877, 2002.
20. Lee, S., Maronian, N., Most, S. P., et al. Porous high-density polyethylene for orbital reconstruction. Arch. Otolaryngol. Head Neck Surg. 131: 446, 2005.
21. Romo, T., III, Fozo, M. S., and Sclafani, A. P. Microtia reconstruction using a porous polyethylene framework. Facial Plast. Surg. 16: 15, 2000.
22. Mole, B. The use of Gore-Tex implants in aesthetic surgery of the face. Plast. Reconstr. Surg. 90: 200, 1992.
23. Gubisch, W., and Kotzur, A. Our experience with silicone in rhinomentoplasty. Aesthetic Plast. Surg. 22: 237, 1998.
24. Evans, G. R., Clark, N., Manson, P. N., and Leipziger, L. S. Role of mini- and microplate fixation in fractures of the midface and mandible. Ann. Plast. Surg. 34: 453, 1995.
25. Clevens, R. A., and Baker, S. R. Conceptual considerations in head & neck reconstruction: Defect analysis and options for reconstruction. Otolaryngol. Clin. North Am. 30: 495, 1997.
26. Hedrick, M. H, Lorenz, H. P., and Miller, T. A. Malignant skin conditions. In B. M. Achauer (Ed.), Plastic Surgery: Indications, Operations, and Outcomes, Vol. 1, 1st Ed. Philadelphia: Mosby, 2000. Pp. 315-324.
27. Vartanian, J. G., Carvalho, A. L., Carvalho, S. M., Mizobe, L., Magrin, J., and Kowalski, L. P. Pectoralis major and other myofascial/myocutaneous flaps in head and neck cancer reconstruction: Experience with 437 cases at a single institution. Head Neck 26: 1018, 2004.
28. Miller, M. J., Robb, G. L., and Schusterman, M. A. Microvascular reconstruction for cutaneous defects. Clin. Plast. Surg. 24: 769, 1997.
29. Yang, J. Y., Tsai, F. C., Chana, J. S., Chuang, S. S., Chang, S. Y., and Huang, W. C. Use of free thin anterolateral thigh flaps combined with cervicoplasty for reconstruction of postburn anterior cervical contractures. Plast. Reconstr. Surg. 110: 39, 2002.
30. Mureau, M. A., Posch, N. A., Meeuwis, C. A., and Hofer, S. O. Anterolateral thigh flap reconstruction of large external facial skin defects: A follow-up study on functional and aesthetic recipient- and donor-site outcome. Plast. Reconstr. Surg. 115: 1077, 2005.
31. Disa, J. J., Liew, S., and Cordeiro, P. G. Soft-tissue reconstruction of the face using the folded/multiple skin island radial forearm free flap. Ann. Plast. Surg. 47: 612, 2001.
32. Carroll, C. M., Pathak, I., Irish, J., Neligan, P. C., and Gullane, P. J. Reconstruction of total lower lip and chin defects using the composite radial forearm-palmaris longus tendon free flap. Arch. Facial Plast. Surg. 2: 53, 2000.
33. Ozdemir, R., Ortak, T., Kocer, U., Celebioglu, S., Sensoz, O., and Tiftikcioglu, Y. O. Total lower lip reconstruction using sensate composite radial forearm flap. J. Craniofac. Surg. 14: 393, 2003.
34. Jeng, S. F., Kuo, Y. R., Wei, F. C., Su, C. Y., and Chien, C. Y. Total lower lip reconstruction with a composite radial forearm-palmaris longus tendon flap: A clinical series. Plast. Reconstr. Surg. 113: 19, 2004.
35. McConnel, F. M., Pauloski, B. R., Logemann, J. A., et al. Functional results of primary closure vs flaps in oropharyngeal reconstruction: A prospective study of speech and swallowing. Arch. Otolaryngol. Head Neck Surg. 124: 625, 1998.
36. Spriano, G., Pellini, R., and Roselli, R. Pectoralis major myocutaneous flap for hypopharyngeal reconstruction. Plast. Reconstr. Surg. 110: 1408, 2002.
37. Mehta, S., Sarkar, S., Kavarana, N., Bhathena, H., and Mehta, A. Complications of the pectoralis major myocutaneous flap in the oral cavity: A prospective evaluation of 220 cases. Plast. Reconstr. Surg. 98: 31, 1996.
38. Chepeha, D. B., Annich, G., Pynnonen, M. A., et al. Pectoralis major myocutaneous flap vs revascularized free tissue transfer: Complications, gastrostomy tube dependence, and hospitalization. Arch. Otolaryngol. Head Neck Surg. 130: 181, 2004.
39. Tsue, T. T., Desyatnikova, S. S., Deleyiannis, F. W., et al. Comparison of cost and function in reconstruction of the posterior oral cavity and oropharynx: Free vs pedicled soft tissue transfer. Arch. Otolaryngol. Head Neck Surg. 123: 731, 1997.
40. Funk, G. F., Karnell, L. H., Whitehead, S., Paulino, A., Ricks, J., and Smith, R. B. Free tissue transfer versus pedicled flap cost in head and neck cancer. Otolaryngol. Head Neck Surg. 127: 205, 2002.
41. Kroll, S. S., Evans, G. R., Goldberg, D., et al. A comparison of resource costs for head and neck reconstruction with free and pectoralis major flaps. Plast. Reconstr. Surg. 99: 1282, 1997.
42. Lueg, E. A. The anterolateral thigh flap: Radial forearm's "big brother" for extensive soft tissue head and neck defects. Arch. Otolaryngol. Head Neck Surg. 130: 813, 2004.
43. Yu, P. Characteristics of the anterolateral thigh flap in a Western population and its application in head and neck reconstruction. Head Neck 26: 759, 2004.
44. Vos, J. D., and Burkey, B. B. Functional outcomes after free flap reconstruction of the upper aerodigestive tract. Curr. Opin. Otolaryngol. Head Neck Surg. 12: 305, 2004.
45. Chana, J. S., and Wei, F. C. A review of the advantages of the anterolateral thigh flap in head and neck reconstruction. Br. J. Plast. Surg. 57: 603, 2004.
46. Huang, C. H., Chen, H. C., Huang, Y. L., Mardini, S., and Feng, G. M. Comparison of the radial forearm flap and the thinned anterolateral thigh cutaneous flap for reconstruction of tongue defects: An evaluation of donor-site morbidity. Plast. Reconstr. Surg. 114: 1704, 2004.
47. Sinha, U. K., Young, P., Hurvitz, K., and Crockett, D. M. Functional outcomes following palatal reconstruction with a folded radial forearm free flap. Ear Nose Throat J. 83: 45, 2004.
48. Makitie, A. A., Beasley, N. J., Neligan, P. C., Lipa, J., Gullane, P. J., and Gilbert, R. W. Head and neck reconstruction with anterolateral thigh flap. Otolaryngol. Head Neck Surg. 129: 547, 2003.
49. Lorenz, R. R., and Alam, D. S. The increasing use of enteral flaps in reconstruction for the upper aerodigestive tract. Curr. Opin. Otolaryngol. Head Neck Surg. 11: 230, 2003.
50. Reece, G. P., Bengtson, B. P., and Schusterman, M. A. Reconstruction of the pharynx and cervical esophagus using free jejunal transfer. Clin. Plast. Surg. 21: 125, 1994.
51. Teichgraeber, J., Bowman, J., and Goepfert, H. Functional analysis of treatment of oral cavity cancer. Arch. Otolaryngol. Head Neck Surg. 112: 959, 1986.
52. Yousif, N. J., Dzwierzynski, W. W., Sanger, J. R., Matloub, H. S., and Campbell, B. H. The innervated gracilis musculocutaneous flap for total tongue reconstruction. Plast. Reconstr. Surg. 104: 916, 1999.
53. Salibian, A. H., Allison, G. R., Armstrong, W. B., et al. Functional hemitongue reconstruction with the microvascular ulnar forearm flap. Plast. Reconstr. Surg. 104: 654, 1999.
54. Haughey, B. H., Beggs, J. C., Bong, J., Genden, E. M., and Buckner, A. Microneurovascular allotransplantation of the canine tongue. Laryngoscope 109: 1461, 1999.
55. Kimata, Y., Sakuraba, M., Hishinuma, S., et al. Analysis of the relations between the shape of the reconstructed tongue and postoperative functions after subtotal or total glossectomy. Laryngoscope 113: 905, 2003.
56. Lyos, A. T., Evans, G. R., Perez, D., and Schusterman, M. A. Tongue reconstruction: Outcomes with the rectus abdominis flap. Plast. Reconstr. Surg. 103: 442, 1999.
57. Yu, P. Reinnervated anterolateral thigh flap for tongue reconstruction. Head Neck 26: 1038, 2004.
58. Kimata, Y., Uchiyama, K., Ebihara, S., et al. Comparison of innervated and noninnervated free flaps in oral reconstruction. Plast. Reconstr. Surg. 104: 1307, 1999.
59. Boyd, J. B., Mulholland, R. S., Davidson, J., et al. The free flap and plate in oromandibular reconstruction: Long-term review and indications. Plast. Reconstr. Surg. 95: 1018, 1995.
60. Schusterman, M. A., Reece, G. P., Kroll, S. S., and Weldon, M. E. Use of the AO plate for immediate mandibular reconstruction in cancer patients. Plast. Reconstr. Surg. 88: 588, 1991.
61. Hidalgo, D. A., and Pusic, A. L. Free-flap mandibular reconstruction: A 10-year follow-up study. Plast. Reconstr. Surg. 110: 438, 2002.
62. Mehta, R. P., and Deschler, D. G. Mandibular reconstruction in 2004: An analysis of different techniques. Curr. Opin. Otolaryngol. Head Neck Surg. 12: 288, 2004.
63. Gabr, E. M., Kobayashi, M. R., Salibian, A. H., et al. Oromandibular reconstruction with vascularized free flaps: A review of 50 cases. Microsurgery 24: 374, 2004.
64. Hurvitz, K. A., and Evans, G. R. Bone and soft tissue reconstruction in tumor surgery with microvascular flaps. In J. Prein (Ed.), AO Craniomaxillofacial Manual. In press.
65. Hibi, H., and Ueda, M. New internal transport distraction device for reconstructing segmental defects of the mandible. Br. J. Oral Maxillofac. Surg. 44: 382, 2005.
66. Rubio-Bueno, P., Naval, L., Rodriguez-Campo, F., Gil-Diez, J. L., and Diaz-Gonzalez, F. J. Internal distraction osteogenesis with a unidirectional device for reconstruction of mandibular segmental defects. J. Oral Maxillofac. Surg. 63: 598, 2005.
67. Raghoebar, G. M., Jansma, J., Vissink, A., and Roodenburg, J. L. Distraction osteogenesis in the irradiated mandible: A case report. J. Craniomaxillofac. Surg. 33: 246, 2005.
68. Li, J., Ying, B., Hu, J., Zhu, S., and Braun, T. W. Reconstruction of mandibular symphyseal defects by trifocal distraction osteogenesis: An experimental study in Rhesus. Int. J. Oral Maxillofac. Surg. 35: 159, 2005.
69. Holmes, S. B., Lloyd, T., Coghlan, K. M., and Newman, L. Distraction osteogenesis of the mandible in the previously irradiated patient. J. Oral Maxillofac. Surg. 60: 305, 2002.
70. Hidalgo, D. A. Fibula free flap: A new method of mandible reconstruction. Plast. Reconstr. Surg. 84: 71, 1989.
71. Hidalgo, D. A., and Rekow, A. A review of 60 consecutive fibula free flap mandible reconstructions. Plast. Reconstr. Surg. 96: 585, 1995.
72. Urken, M. L., Bridger, A. G., Zur, K. B., and Genden, E. M. The scapular osteofasciocutaneous flap: A 12-year experience. Arch. Otolaryngol. Head Neck Surg. 127: 862, 2001.
73. Schpitzer, T., Neligan, P. C., Gullane, P. J., et al. The free iliac crest and fibula flaps in vascularized oromandibular reconstruction: Comparison and long-term evaluation. Head Neck 21: 639, 1999.
74. Disa, J. J., and Cordeiro, P. G. Mandible reconstruction with microvascular surgery. Semin. Surg. Oncol. 19: 226, 2000.
75. Cordeiro, P. G., Disa, J. J., Hidalgo, D. A., and Hu, Q. Y. Reconstruction of the mandible with osseous free flaps: A 10-year experience with 150 consecutive patients. Plast. Reconstr. Surg. 104: 1314, 1999.
76. Cordeiro, P. G., Disa, J. J., Hidalgo, D. A., and Hu, Q. Y. Reconstruction of the mandible with osseous free flaps: A 10-year experience with 150 consecutive patients. Plast. Reconstr. Surg. 104: 1314, 1999.
77. Wei, F. C., Demirkan, F., Chen, H. C., and Chen, I. H. Double free flaps in reconstruction of extensive composite mandibular defects in head and neck cancer. Plast. Reconstr. Surg. 103: 39, 1999.
78. Gabr, E., Kobayashi, M. R., Salibian, A. H., et al. Mandibular reconstruction: Are two flaps better than one? Ann. Plast. Surg. 52: 31, 2004.
79. Gabr, E. M., Kobayashi, M. R., Salibian, A. H., et al. Role of ulnar forearm free flap in oromandibular reconstruction. Microsurgery 24: 285, 2004.
80. Kuzon, W. M., Jr., Jejurikar, S., Wilkins, E. G., and Swartz, W. M. Double free-flap reconstruction of massive defects involving the lip, chin, and mandible. Microsurgery 18: 372, 1998.
81. Deschler, D. G., and Hayden, R. E. The optimum method for reconstruction of complex lateral oromandibular-cutaneous defects. Head Neck 22: 674, 2000.
82. Blackwell, K. E., and Lacombe, V. The bridging lateral mandibular reconstruction plate revisited. Arch. Otolaryngol. Head Neck Surg. 125: 988, 1999.
83. Shpitzer, T., Gullane, P. J., Neligan, P. C., et al. The free vascularized flap and the flap plate options: Comparative results of reconstruction of lateral mandibular defects. Laryngoscope 110: 2056, 2000.
84. Poli, T., Ferrari, S., Bianchi, B., and Sesenna, E. Primary oromandibular reconstruction using free flaps and thorp plates in cancer patients: A 5-year experience. Head Neck 25: 15, 2003.
85. Head, C., Alam, D., Sercarz, J. A., et al. Microvascular flap reconstruction of the mandible: A comparison of bone grafts and bridging plates for restoration of mandibular continuity. Otolaryngol. Head Neck Surg. 129: 48, 2003.
86. Wei, F. C., Celik, N., Yang, W. G., Chen, I. H., Chang, Y. M., and Chen, H. C. Complications after reconstruction by plate and soft-tissue free flap in composite mandibular defects and secondary salvage reconstruction with osteocutaneous flap. Plast. Reconstr. Surg. 112: 37, 2003.
87. Urken, M. L., Buchbinder, D., Costantino, P. D., et al. Oromandibular reconstruction using microvascular composite flaps: Report of 210 cases. Arch. Otolaryngol. Head Neck Surg. 124: 46, 1998.
88. Hidalgo, D. A. Condyle transplantation in free flap mandible reconstruction. Plast. Reconstr. Surg. 93: 770, 1994.
89. Kroll, S. S., Robb, G. L., Miller, M. J., Reese, G. P., and Evans, G. R. Reconstruction of posterior mandibular defects with soft tissue using the rectus abdominis free flap. Br. J. Plast. Surg. 51: 503, 1998.
90. Butler, C. E., and Lewin, J. S. Reconstruction of large composite oromandibulomaxillary defects with free vertical rectus abdominis myocutaneous flaps. Plast. Reconstr. Surg. 113: 499, 2004.
91. Patel, A., and Maisel, R. Condylar prostheses in head and neck cancer reconstruction. Arch. Otolaryngol. Head Neck Surg. 127: 842, 2001.
92. Ung, F., Rocco, J. W., and Deschler, D. G. Temporary intraoperative external fixation in mandibular reconstruction. Laryngoscope 112: 1569, 2002.
93. Schusterman, M. A., Reece, G. P., and Miller, M. J. Osseous free flaps for orbit and midface reconstruction. Am. J. Surg. 166: 341, 1993.
94. Foster, R. D., Anthony, J. P., Singer, M. I., Kaplan, M. J., Pogrel, M. A., and Mathes, S. J. Reconstruction of complex midfacial defects. Plast. Reconstr. Surg. 99: 1555, 1997.
95. Muzaffar, A. R., Adams, W. P., Jr., Hartog, J. M. Rohrich, R. J., and Byrd, H. S. Maxillary reconstruction: Functional and aesthetic considerations. Plast. Reconstr. Surg. 104: 2172, 1999.
96. Cordeiro, P. G., Santamaria, E., Kraus, D. H., Strong, E. W., and Shah, J. P. Reconstruction of total maxillectomy defects with preservation of the orbital contents. Plast. Reconstr. Surg. 102: 1874, 1998.
97. Kroll, S. S., and Baldwin, B. J. Head and neck reconstruction with the rectus abdominis free flap. Clin. Plast. Surg. 21: 97, 1994.
98. Cordeiro, P. G., and Disa, J. J. Challenges in midface reconstruction. Semin. Surg. Oncol. 19: 218, 2000.
99. Coskunfirat, O. K., Wei, F. C., Huang, W. C., Cheng, M. H., Yang, W. G., and Chang, Y. M. Microvascular free tissue transfer for treatment of osteoradionecrosis of the maxilla. Plast. Reconstr. Surg. 115: 54, 2005.
100. Fukuta, K., Saito, K., Takahashi, M., and Torii, S. Surgical approach to midline skull base tumors with olfactory preservation. Plast. Reconstr. Surg. 100: 318, 1997.
101. Sinha, U. K., Johnson, T. E., Crockett, D., Vadapalli, S., and Gruen, P. Three-layer reconstruction for large defects of the anterior skull base. Laryngoscope 112: 424, 2002.
102. Clayman, G. L., DeMonte, F., Jaffe, D. M., et al. Outcome and complications of extended cranial-base resection requiring microvascular free-tissue transfer. Arch. Otolaryngol. Head Neck Surg. 121: 1253, 1995.
103. Neligan, P. C., Mulholland, S., Irish, J., et al. Flap selection in cranial base reconstruction. Plast. Reconstr. Surg. 98: 1159, 1996.
104. Disa, J. J., Rodriguez, V. M., and Cordeiro, P. G. Reconstruction of lateral skull base oncological defects: The role of free tissue transfer. Ann. Plast. Surg. 41: 633, 1998.
105. Moyer, J. S., Chepeha, D. B., and Teknos, T. N. Contemporary skull base reconstruction. Curr. Opin. Otolaryngol. Head Neck Surg. 12: 294, 2004.
106. Iida, H. The advantage of the anterolateral thigh flap for reconstruction of the anterior skull base defect in recurrent cases. Plast. Reconstr. Surg. 112: 703, 2003.
107. Orticochea, M. Four flap scalp reconstruction technique. Br. J. Plast. Surg. 20: 159, 1967.
108. Orticochea, M. New three-flap reconstruction technique. Br. J. Plast. Surg. 24: 184, 1971.
109. Juri, J. Use of parieto-occipital flaps in the surgical treatment of baldness. Plast. Reconstr. Surg. 55: 456, 1975.
110. Hurvitz, K. A., Rosen, H., and Meara, J. G. Pediatric cervicofacial tissue expansion. Int. J. Pediatr. Otorhinolaryngol. 69: 1509, 2005.
111. Ioannides, C., Fossion, E., and McGrouther, A. D. Reconstruction for large defects of the scalp and cranium. J. Craniomaxillofac. Surg. 27: 154, 1999.
112. Fennis, J. P. M., Stoelinga, P. J. W., Merkx, M. A. W., and Jansen, J. A. Reconstruction of the mandible with poly(d,l-lactide) scaffold, autologous corticocancellous bone graft, and autogenous platelet-rich plasma: An animal experiment. Tissue Eng. 11: 1045, 2005.
113. Arosarena, O. A., and Collins, W. L. Bone regeneration in the rat mandible with bone morphogenetic protein-2: A comparison of two carriers. Otolaryngol. Head Neck Surg. 132: 592, 2005.
114. Ashinoff, R. L. Cetrulo, C. L., Galiano, R. D., et al. Bone morphogenic protein-2 gene therapy for mandibular distraction osteogenesis. Ann. Plast. Surg. 52: 585, 2004.
115. Nussenbaum, B., Teknos, T. N., and Chepeha, D. B. Tissue engineering: The current status of this futuristic modality in head neck reconstruction. Curr. Opin. Otolaryngol. Head Neck Surg. 12: 311, 2004.
116. Evans, G. R. D. Advances in head and neck reconstruction: Applications of tissue engineering. Semin. Plast. Surg. 17: 409, 2003.