Progress in epilepsy: Reducing the treatment gap and the promise of biomarkers

Current Opinion in Neurology

Volumn 21, Issue 2, 2008, Pages 150-154

  Engel Jr , Jerome ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biomarkers; Epilepsy; Epileptogenesis; Epileptogenicity; Treatment gap

Indexed keywords

ANTICONVULSIVE AGENT; BIOLOGICAL MARKER;

DISABILITY; DISEASE COURSE; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; EPILEPSY; EPILEPTOGENESIS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE EXPRESSION; HUMAN; MEDICAL RESEARCH; MICROARRAY ANALYSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; QUALITY CONTROL; REVIEW; RISK FACTOR; TRANSCRANIAL MAGNETIC STIMULATION;

ANTICONVULSANTS; BIOLOGICAL MARKERS; BRAIN; DIAGNOSTIC IMAGING; DRUG DESIGN; EARLY DIAGNOSIS; EPILEPSY; HUMANS; INTERNATIONAL COOPERATION; WORLD HEALTH;

EID: 43149092929     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/WCO.0b013e3282f4edc3     Document Type: Review

References (35)

1. Kinnier Wilson JV, Reynolds EH. Translation and analysis of a cuniform text forming part of a Babylonian treatise on epilepsy. Med Hist 1990; 34:185-198.
2. Mishra SK, Vinjamury SP. Neurological disorders in Ayurveda. Int J Integr Med 2001; 3:13-16.
3. Banerjee PN, Hauser WA. Incidence and prevalence. In: Engel Jr J, Pedley TA, editors. Epilepsy: a comprehensive textbook, 2nd ed. Philadelphia: Lippincott-Raven; 2008. pp. 45-56. This is a review of the incidence and prevalence of epilepsy in a recently published textbook on epilepsy.
4. Hauser WA, Hesdorffer DC. Epilepsy: frequency, causes and consequences. New York: Demos Press; 1990.
5. Murray CJL, Lopez AD, editors. Global comparative assessment in the health sector: disease burden, expenditures, and intervention packages. Geneva: WHO; 1994.
6. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342:314-319.
7. Begley CE, Famulari M, Annegers JF, et al. The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia 2000; 41:342-351.
8. Meinardi H, Scott RA, Reis R, Sander JWAS, on behalf of the ILAE Commission on the Developing World. The treatment gap in epilepsy: the current situation and ways forward. Epilepsia 2001; 42:136-149.
9. Reynolds EH, editor. Epilepsy in the world: launch of the second phase of the ILAE/IBE/WHO Global Campaign against Epilepsy. Epilepsia 2002; 43 (Suppl 6):1-47.
10. Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHOstudy. Neurology 2003; 60:1544-1545.
11. Ndoye NF, Sow AD, Diop AG, et al. Prevalence of epilepsy its treatment gap and knowledge, attitude and practice of its population in sub-urban Senegal an ILAE/IBE/WHO study. Seizure 2005; 14:106-111.
12. World Health Organization. Atlas: epilepsy care in the world. Geneva: World Health Organization; 2005.
13. Dua T, de Boer HM, Prilipko LL, Saxena S. Epilepsy care in the world: results of an ILAE/IBE/WHO Global Campaign against Epilepsy survey. Epilepsia 2006; 47:1225-1231.
14. Jacobs MP, Fischbach GD, Davis MR, et al. Future directions for epilepsy research. Neurology 2001; 57:1536-1542.
15. Berg AT, Langfitt J, Shinnar S, et al. How long does it take for partial epilepsy to become intractable? Neurology 2003; 60:186-190.
16. Roch C, Leroy C, Nehlig A, Namer IJ. Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model. Epilepsia 2002; 43:1129-1136.
17. Lewis DV, Shinnar S. Febrile status epilepticus. In: Engel Jr J, Pedley TA, editors. Epilepsy: a comprehensive textbook, 2nd ed. Philadelphia: Lippincott-Raven; 2008. pp. 731-736. This review of febrile status epilepticus, from a recently published textbook, contains the background for the new MRI study to determine if poststatus MRI changes predict subsequent epilepsy.
18. Lin JJ, Salamon N, Dutton RA, et al. Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy. Neurology 2005; 65:1094-1097.
19. Lin JJ, Salamon N, Lee AD, et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cerebral Cortex 2007; 17:2007-2018. This paper describes a novel MRI analysis technique to assess abnormalities in neocortical thickness, as a follow up to Ref. [18], which addressed hippocampal abnormalities in patients with mesial temporal lobe epilepsy. If this technique identifies structural characteristics that predict pharmacoresistance and postoperative outcome, it would be important for identifying candidates for surgical therapy.
20. Bragin A, Engel Jr J, Wilson CL, et al. Hippocampal and entorhinal cortex high frequency oscillations (100-500Hz) in kainic acid-treated rats with chronic seizures and human epileptic brain. Epilepsia 1999; 40:127-137.
21. Bragin A, Wilson CL, Almajano J, et al. High frequency oscillations after status epilepticus: epileptogenesis and seizure genesis. Epilepsia 2004; 45:1017-1023.
22. Bragin A, Wilson CL, Engel Jr J. Spatial stability over time of brain areas generating fast ripples in the epileptic rat. Epilepsia 2003; 44:1233-1237.
23. Staba RJ, Wilson CL, Bragin A, et al. Quantitative analysis of high frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. J Neurophysiol 2002; 88:1743-1752.
24. Urrestarazu E, Chandler R, Dubeau F, Gotman J. Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients. Brain 2007; 130:2354-2366. Pathological high-frequency oscillations appear to be biomarkers of epileptogenicity, but originally required microelectrode recordings for their identification. This paper describes hippocampal and cortical high-frequency oscillations recorded with standard depth and subdural electrodes, and confirms their ability to localize the epileptogenic region.
25. Laufs H, Duncan JS. Electroencephalography/functional MRI in human epilepsy: what it currently can and cannot do. Curr Opin Neurol 2007; 20:417-423. The localization of blood flow changes associated with interictal spikes can be determined by EEG-fMRI. This article reviews the potential utility of this increasingly available technique.
26. Valentin A, Arunachalam R, Mesquita-Rodrigues A, et al. Late EEG responses triggered by transcranial magnetic stimulation (TMS) in the evaluation of focal epilepsy. Epilepsia 2007; 19 November [Epub ahead of print]. Transcranial magnetic stimulation traditionally uses motor responses to assess cortical excitability. This paper describes a technique that permits more direct measures of cortical excitability that would be applicable to diagnosis of epileptogenic regions outside the motor cortex.
27. Fedi M, Reutens D, Okazawa H, et al. Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin. Neurology 2001; 57:1629-1636.
28. Juhasz C, Chugani HT. Imaging the epileptic brain with positron emission tomography. Neuroimaging Clin N Am 2003; 13:705-716.
29. Juhasz C, Chugani DC, Muzik O, et al. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003; 60:960-968.
30. Kagawa K, Chugani DC, Asano E, et al. Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L- tryptophan positron emission tomography (PET). J Child Neurol 2005; 20:429-438.
31. Natsume J, Kumakura Y, Bernasconi N, et al. Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy. Neurology 2003; 60:756-761.
32. Akhtari M, Engel Jr J. Patent nos. PCT/US06/10334, EU06739214.2.
33. Parent JM, Coulter DA, Bertram EH. The effect of seizures on the brain. In: Engel Jr J, Pedley TA, editors. Epilepsy: a comprehensive textbook, 2nd ed. Philadelphia: Lippincott-Raven; 2008. pp. 481-493. This review from a recently published textbook contains a discussion of neurogenesis in the epileptic hippocampus.
34. Engel Jr J, Williamson PD, Wieser HG. Mesial temporal lobe epilepsy with hippocampal sclerosis. In: Engel Jr J, Pedley TA, editors. Epilepsy: a comprehensive textbook, 2nd ed. Philadelphia: Lippincott-Raven; 2008. pp. 2479-2486. This is a review of mesial temporal lobe epilepsy with hippocampal sclerosis in a recently published textbook.
35. Manganas LN, Zhang X, Li Y, et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 2007; 318:980-985. This paper suggests that magnetic resonance spectroscopy can be used to identify neurogenesis in the human hippocampus. Detection of enhanced neurogenesis with this technique could serve as a useful biomarker of epileptogenesis or epileptogenicity.