Emerging topical antimicrobial options for mild-to-moderate acne: A review of the clinical evidence

Journal of Drugs in Dermatology

Volumn 7, Issue 2, 2008, Pages

  Del Rosso, James ^a  

^a VALLEY HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BENZOYL PEROXIDE; DERMATOLOGICAL AGENT; LIPOSOME; RETINOID;

ACNE VULGARIS; DRUG COMBINATION; HUMAN; REVIEW; TOPICAL DRUG ADMINISTRATION;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ANTI-BACTERIAL AGENTS; BENZOYL PEROXIDE; DERMATOLOGIC AGENTS; DRUG COMBINATIONS; HUMANS; LIPOSOMES; RETINOIDS;

EID: 43149085296     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Leyden JJ. The evolving role of Propionibacterium acnes in acne. Semin Cutan Med Surg. 2001;20:139-143. (Pubitemid 32927775)
2. Erianne J, Prince DL, Ramirez J, Wilson D, Zeichner J. The pharmacologic science of a novel benzoyl peroxide formulation and the implications for clinical effects. Poster presented at: 25th Anniversary Fall Clinical Dermatology Conference®; October 6-9, 2006; Las Vegas, NV.
3. Simonart T, Dramaix M. Treatment of acne with topical antibiotics: lessons from clinical studies. Br J Dermatol. 2005;153:395-403.
4. Leyden JJ. Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes. Cutis. 2002;69:475-480.
5. Lookingbill DP, Chalker DK, Lindholm JS, et al. Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: combined results of two double-blind investigations. J Am Acad Dermatol. 1997;37:590-595.
6. Cunliffe WJ, Holland KT, Bojar R, et al. A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. Clin Ther. 2002;24:1117-1133.
7. Liu PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: All-trans retinoic acid down-regulates TLR2 expression and function. J Immunol. 2005;174:2467-2470.
8. Nagpal S, Chandraratna RA. Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000;6:919-931.
9. Thacher SM, Vasudevan J, Chandraratna RA. Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000;6:25-58.
10. Martin B, Meunier C, Montels D, Watts O. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation. Br J Dermatol. 1998;139(suppl 52):8-11.
11. Shalita AR, Rafal ES, Anderson DN, Yavel R, Landow S, Lee WL. Compared efficacy and safety of tretinoin 0.1% microsphere gel alone and in combination with benzoyl peroxide 6% cleanser for the treatment of acne vulgaris. Cutis. 2003;72:167-172.
12. Del Rosso JQ. Study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris. J Drugs Dermatol. 2007;6:616-622.
13. Schlessinger J, Menter A, Gold M, et al. Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris. J Drugs Dermatol. 2007;6:607-615.
14. Gupta AK, Nichol K. The use of sulfur in dermatology. J Drugs Dermatol. 2004;3:427-431.
15. Abramovits W, Kennedy AJ. Sulfur/sodium sulfacetamide preparations. SkinMed: Dermatol Clin. 2004;3:95-101.
16. Azelex (azelaic acid 20% cream) [package insert]. Irvine, CA: Allergan, Inc; 2003.
17. Draelos ZD. The rationale for advancing the formulation of azelaic acid vehicles. Cutis. 2006;77(suppl):7-11.
18. Thiboutot DM. Versatility of azelaic acid (AzA) 15% gel in treatment of acne vulgaris: a review of clinical literature. Poster presented at: American Academy of Dermatology 65th Annual Meeting; February 2-6, 2007; Washington DC.
19. Wilson DC. Evaluation of a novel acne treatment system (CLENZIderm MD™) designed to enhance the efficacy of benzoyl peroxide treatment: an investigator-blind, randomized study. Poster presented at: Winter Clinical Dermatology Conference - Hawaii® ; January 13-17, 2007; Kohala Coast, Hawaii.
20. Del Rosso JQ, Bikowski JB, Baum E, et al. A closer look at truncal acne vulgaris: prevalence, severity, and clinical significance. J Drugs Dermatol. 2007;6:597-600.