Quantification of liver perfusion with [15O]H2O-PET and its relationship with glucose metabolism and substrate levels

Journal of Hepatology

Volumn 48, Issue 6, 2008, Pages 974-982

  Slimani, Lotfi ^a   Kudomi, Nobuyuki ^a   Oikonen, Vesa ^a   Jarvisalo, M ^a   Kiss, Jan ^a   Naum, Alexandru ^a   Borra, Ronald ^a   Viljanen, Antti ^a   Sipila, Hannu ^a   Ferrannini, Ele ^b,c   Savunen, Timo ^a   Nuutila, Pirjo ^a   Iozzo, Patricia ^a,b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

Compartmental modeling; Hepatic artery; Hepatic blood flow; Liver metabolism; Parameter estimation; Portal vein

Indexed keywords

GLUCOSE; OXYGEN 15; WATER;

ARTERY PERFUSION; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; ECHOGRAPHY; GLUCOSE METABOLISM; KINETICS; LIPID METABOLISM; LIVER BLOOD FLOW; LIVER PERFUSION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ANIMALS; FASTING; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HYPERINSULINISM; LACTATES; LIPID METABOLISM; LIVER; MODELS, BIOLOGICAL; OXYGEN RADIOISOTOPES; PERFUSION; POSITRON-EMISSION TOMOGRAPHY; SWINE; TRIGLYCERIDES; ULTRASONOGRAPHY, DOPPLER;

EID: 43049180025     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.029     Document Type: Article

References (43)

1. Duvoux C., Radier C., Roudot-Thoraval F., Maille F., Anglade M.C., Van Nhieu J.T., et al. Low-grade steatosis and major changes in portal flow as new prognostic factors in steroid-treated alcoholic hepatitis. Hepatology 40 (2004) 1370-1378
2. Magalotti D., Marchesini G., Ramilli S., Berzigotti A., Bianchi G., and Zoli M. Splanchnic haemodynamics in non-alcoholic fatty liver disease: effect of a dietary/pharmacological treatment. A pilot study. Dig Liver Dis 36 (2004) 406-411
3. Bearn A.G., Billing B., Edholm O.G., and Sherlock S. Hepatic blood flow and carbohydrate changes in man during fainting. J Physiol 115 (1951) 442-455
4. Topping D.L., Storer G.B., and Trimble R.P. Effects of flow rate and insulin on triacylglycerol secretion by perfused rat liver. Am J Physiol 255 (1988) E306-E313
5. Arai K., Matsui O., Takashima T., Ida M., and Nishida Y. Focal spared areas in fatty liver caused by regional decreased portal flow. AJR Am J Roentgenol 151 (1988) 300-302
6. Gabata T., Kadoya M., Matsui O., Ueda K., Kawamori Y., Terayama N., et al. Peritumoral spared area in fatty liver: correlation between opposed-phase gradient-echo MR imaging and CT arteriography. Abdom Imaging 26 (2001) 384-389
7. Katz M.L., and Bergmann E.N. Simultaneous measurement of hepatic and portal venous blood flow in the sheep and dog. Am J Physiol 216 (1969) 946-952
8. Johnson D.J., Muhlbacher F., and Wilmore D.W. Measurement of hepatic blood flow. J Surg Res 39 (1985) 470-481
9. Ziegler S.I., Haberkorn U., Byrne H., Tong C., Kaja S., Richolt J.A., et al. Measurement of liver blood flow using oxygen-15 labelled water and dynamic positron emission tomography: limitations of model description. Eur J Nucl Med 23 (1996) 169-177
10. Greenway C.V. Hepatic plethysmography. In: Lautt W.W. (Ed). Hepatic circulation in health and disease (1981), Raven Press, New York 41-54
11. Anderson M.F. Pulsed Doppler ultrasonic flowmeter: application to the study of hepatic blood flow. In: Granger D.N., and Bulkley G.B. (Eds). Measurement of blood flow applications to the splanchnic circulation (1981), Williams & Wilkins, Baltimore 395-398
12. Huet P.M., Goresky C.A., Villeneuve J.P., and Marleau D. Assessment of liver microcirculation in human cirrhosis. J Clin Invest 70 (1982) 1234-1244
13. Seifalian A.M., Piasecki C., Agarwal A., and Davidson B.R. The effect of graded steatosis on flow in the hepatic parenchymal microcirculation. Transplantation 68 (1999) 780-784
14. Ruotsalainen U., Raitakari M., Nuutila P., Oikonen V., Sipila H., Teras M., et al. Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET. J Nucl Med 38 (1997) 314-319
15. Viljanen K.A., Lonnroth P., Parkkola R., Peltoniemi P., Asola M., Viljanen T., et al. Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab 87 (2002) 3902-3910
16. 15O. Circulation 70 (1984) 724-733
17. 15O. I. Theory and error analysis. J Nucl Med 24 (1983) 782-789
18. 15O. II. Implementation and validation. J Nucl Med 24 (1983) 790-798
19. 15O]water and positron emission tomography. Nucl Med Commun 24 (2003) 497-501
20. Taniguchi H., Yamaguchi A., Kunishima S., Koh T., Masuyama M., Koyama H., et al. Using the spleen for time-delay correction of the input function in measuring hepatic blood flow with oxygen-15 water by dynamic PET. Ann Nucl Med 13 (1999) 215-221
21. Taniguchi H., Oguro A., Koyama H., Masuyama M., and Takahashi T. Analysis of models for quantification of arterial and portal blood flow in the human liver using PET. J Comput Assist 20 (1996) 135-144
22. Munk O.L., Bass L., Feng H., and Keiding S. Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers. J Nucl Med 44 (2003) 1862-1870
23. Iozzo P., Jarvisalo M.J., Kiss J., Borra R., Naum G.A., Viljanen A., et al. Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology 132 (2007) 531-542
24. Iozzo P., Gastaldelli A., Jarvisalo M.J., Kiss J., Borra R., Buzzigoli E., et al. 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. J Nucl Med 47 (2006) 1016-1022
25. Iozzo P., Hallsten K., Oikonen V., Virtanen K.A., Kemppainen J., Solin O., et al. Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control. J Clin Endocrinol Metab 88 (2003) 2055-2060
26. Muscelli E., Mari A., Natali A., Astiarraga B.D., Camastra S., Frascerra S., et al. Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab 291 (2006) E1144-E1150
27. Kety S.S., and Schmidt C.F. The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27 (1948) 476-483
28. SAAM Institute 1998 SAAM II User's guide version 1.1.1. WA: SAAM Institute, Seattle.
29. Cobelli C., Foster D., and Toffolo G. Tracer kinetics in biomedical research: from data to model (2001), Kluwer Academic/Plenum, New York
30. Bland J.M., and Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1 (1986) 307-310
31. Keiding S., Munk O.L., Vilstrup H., Nielsen D.T., Roelsgaard K., and Bass L. Hepatic microcirculation assessed by positron emission tomography of first pass ammonia metabolism in porcine liver. Liver Int 25 (2005) 171-176
32. Sherman I.A., Dlugosz J.A., Barker F., Sadeghi F.M., and Pang K.S. Dynamics of arterial and portal venous flow interactions in perfused rat liver: an intravital microscopic study. Am J Physiol 271 (1996) G201-G210
33. Doi R., Inoue K., Kogire M., Sumi S., Takaori K., Suzuki T., et al. Simultaneous measurement of hepatic arterial and portal venous flows by transit time ultrasonic volume flowmetry. Surg Gynecol Obstet 167 (1988) 65-69
34. Kleber G., Steudel N., Behrmann C., Zipprich A., Hübner G., Lotterer E., et al. Hepatic arteriel flow volume and reserve in patients with cirrhosis: use of intra-arteriel Doppler and adenosine infusion. Gastroenterology 116 (1999) 906-914
35. Hubner G.H., Steudel N., Kleber G., Behrmann C., Lotterer E., and Fleig W.E. Hepatic arteriel blood flow velocities: assessment by transcutaneous and intravascular Doppler sonography. J Hepatol 32 (2000) 893-899
36. Materne R., Van Beers B.E., Smith A.M., Leconte I., Jamart J., Dehoux J.P., et al. Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model. Clin Sci (Lond) 99 (2000) 517-525
37. Satake S., Moore M.C., Igawa K., Converse M., Farmer B., Neal D.W., et al. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes 51 (2002) 1663-1671
38. Simonsen L., Coker R., Mulla N.A.L., Kjaer M., and Bulow J. The effect of insulin and glucagon on splanchnic oxygen consumption. Liver 22 (2002) 459-466
39. Capaldo B., Gastaldelli A., Antoniello S., Auletta M., Pardo F., Ciociaro D., et al. Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans. Diabetes 48 (1999) 958-966
40. Jakob S.M., Tenhunen J.J., Laitinen S., Heino A., Alhava E., and Takala J. Effects of systemic arterial hypoperfusion on splanchnic hemodynamics and hepatic arterial buffer response in pigs. Am J Physiol Gastrointest Liver Physiol 280 (2001) G819-G827
41. Seifalian A.M., El-Desoky A., and Davidson B.R. Hepatic indocyanine green uptake and excretion in a rabbit model of steatosis. Eur Surg Res 33 (2001) 193-201
42. Lautt W.W. Relationship between hepatic blood flow and overall metabolism: the hepatic arterial buffer response. Fed Proc 42 (1983) 1662-1666
43. Kakkos S.K., Yarmenitis S.D., Tsamandas A.C., Gogos C.A., and Kalfarentzos F. Fatty liver in obesity: relation to Doppler perfusion index measurement of the liver. Scand J Gastroenterol 35 (2000) 976-980