Measurement of liver blood flow using oxygen-15 labelled water and dynamic positron emission tomography: Limitations of model description

European Journal of Nuclear Medicine

Volumn 23, Issue 2, 1996, Pages 169-177

  Ziegler, Sibylle I ^a,d   Haberkorn, Uwe ^a   Byrne, Helen ^c   Tong, Carrison ^c   Schosser, Rudolph ^b   Krieter, Heiner ^b   Kaja, Stefan ^b   Richolt, Jens A ^b   Lammertsma, Adriaan A ^c   Price, Patricia ^c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Liver perfusion; Modelling; Oxygen 15 labelled water; Positron emission tomography

Indexed keywords

MICROSPHERE; OXYGEN 15; WATER;

ANIMAL EXPERIMENT; AORTA; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOWMETRY; COMPARTMENT MODEL; DOG; HEPATIC ARTERY; INTRAVENOUS DRUG ADMINISTRATION; LIVER BLOOD FLOW; LIVER SCINTISCANNING; NONHUMAN; PORTAL VEIN; PORTAL VEIN BLOOD FLOW; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; DOGS; LIVER; LIVER CIRCULATION; MICROSPHERES; MODELS, THEORETICAL; OXYGEN RADIOISOTOPES; TOMOGRAPHY, EMISSION-COMPUTED; WATER;

EID: 9044221368     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01731841     Document Type: Article

References (33)

1. Johnson DJ, Muhlbacher F, Wilmore DW. Measurement of hepatic blood flow. J Surg Res 1985; 39: 470-481.
2. Taniguchi H, Daidoh T, Shioki Y, Takahashi T. Blood supply and drug delivery to primary and secondary human liver cancers studied with in vivo bromodeoxyuridine labeling. Cancer 1993; 71: 50-55.
3. Greenway CV. In: Lautt WW, ed. Hepatic plethysmography in hepatic circulation in health and disease. New York: Raven Press; 1981: 41-54.
4. Kolin A. An electromagnetic flow meter. Principles of the method and its application to blood flow measurements. Proc Soc Exp Biol Med 1936; 35: 53-56.
5. Anderson MF. Pulsed Doppler ultrasonic flowmeter: application to the study of hepatic blood flow. In: Granger DN, Bulkley GB, eds. Measurement of blood flow: applications to the splanchnic circulation. Baltimore: Williams & Wilkins; 1981: 395-398.
6. Gibbs FAA. A thermoelectric blood flow recorder in form of a needle. Proc Soc Exp Biol Med 1933; 31: 141-146.
7. Schmitz-Feuerhake I, Huchzermeyer H, Reblin T. Determination of the specific blood flow of the liver by inhalation of radioactive rare gases. Acta Hepatogastroenterol 1975; 22: 150-158.
8. 133Xe clearance after portal vein injection. Gut 1977; 18: 1027-1031.
9. 133xenon. Acta Chir Scand 1979; 145: 95-100.
10. Biersack HJ, Torres J, Thelen M, Monzon O, Winkler C. Determination of liver and spleen perfusion by quantitative sequential scintigraphy in normal subjects and in patients with portal hypertension. Clin Nucl Med 1981; 6: 218-220.
11. Fleming JS, Ackery DM, Walmsley BH, Karran SJ. Scintigraphic estimation of arterial and portal blod supplies to the liver. J Nucl Med 1983; 24: 1108-1113.
12. 15O and positron emission tomography: theory, procedure and normal values. J Comput Assist Tomogr 1980; 4: 727-736.
13. 15O. I. Theory and error analysis. J Nucl Med 1983; 24: 782-789.
14. 15O. II. Implementation and validation. J Nucl Med 1983; 24: 790-798.
15. Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, Frackowiak RSJ, Jones T. Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab 1990; 10: 675-686.
16. 15O. Circulation 1984; 70: 724-733.
17. 2 and positron emission tomography: comparison of tracer models. Clin Phys Physiol Meas 1992; 13: 1-20.
18. Goresky CA. A linear method for determining liver sinusoidal and extravascular volumes. Am J Physiol 1963; 204: 626-640.
19. 2O and antipyrine in isolated perfused rat liver. Am J Physiol 1985; 192: 531-537.
20. Griffen WO, Levitt DG, Ellis CJ, Lifson N. Intrahepatic distribution of hepatic blood flow: single-input studies. Am J Physiol 1970; 218: 1474-1479.
21. Lifson N, Levitt DG, Giffen WO, Ellis CJ. Intrahepatic distribution of hepatic blood flow: double-input studies. Am J Physiol 1970; 218: 1480-1488.
22. Kety SS. Measurement of local blood flow by the exchange of an inert, diffusible substance. Methods Med Res 1960; 8: 228-236.
23. Heymann MA, Payne BD, Hoffman JIE, Rudolph AM. Blood flow measurements with radionuclide-labelled particles. Prog Cardiovasc Dis 1977; 1977: 55-79.
24. Zwissler B, Schosser R, Weiss C, Iber V, Weiss M, Schwickert C, Spengler P, Messmer K. Methodological error and spatial variability of organ flow measurements using radiolabelled microspheres. Res Exp Med 1991; 191: 47-63.
25. Gross W, Schosser R, Messmer K. MIC-III - An integrated software package to support experiments using the radioactive microsphere technique. Comput Methods Programs Biomed 1990; 33: 65-85.
26. Holte S, Ostertag H, Kesselberg M. A preliminary evaluation of a dual crystal positron camera. J Comput Assist Tomogr 1987; 11: 691-697.
27. Eriksson L, Holte S, Bohm C, Kesselberg M, Hovander B. Automated blood sampling systems for positron emission tomography. IEEE Trans Nucl Sci 1988; NS-35: 703-707.
28. Schmidlin P, Kuebler WK, Doll J, Strauss LG, Ostertag H. Image processing in whole body positron emission tomography. In: Schmidt HAE, Csernay L, eds. Nuklearmedizin. Stuttgart: Schattauer; 1987: 84-87.
29. 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function. J Cereb Blood Flow Metab 1986; 36: 536-545.
30. 15O autoradiographic method and dynamic PET. J Nucl Med 1989; 30: 1069-1078.
31. Bol A, Vanmelckenbeke P, Michel C, Cogneau M, Gaffinet AM. Measurement of cerebral blood flow with a bolus of oxygen-15-labelled water: comparison of dynamic and integral methods. Eur J Nucl Med 1990; 17: 234-241.
32. Greenway CV. Hepatic vascular bed. Physiol Rev 1971; 51: 23-65.
33. Chen BC, Huang SC, Germano G, Kuhle W, Hawkins RA, Buxton D, Brunken RC, Scheibert HR, Phelps ME. Noninvasive quantification of hepatic arterial blood flow with nitrogen-13-ammonia and dynamic positron emission tomography. J Nucl Med 1991; 32: 2199-2208.