Uncatalyzed, anti-Michael addition of amines to β-nitroacrylates: practical, eco-friendly synthesis of β-nitro-α-amino esters

Tetrahedron Letters

Volumn 49, Issue 24, 2008, Pages 3865-3867

  Ballini, Roberto ^a   Bazán, Noelia Araújo ^a   Bosica, Giovanna ^a   Palmieri, Alessandro ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Nitro amino esters; Amines; Anti Michael addition; Solvent free; Uncatalyzed reaction

Indexed keywords

ACRYLIC ACID DERIVATIVE; AMINE; BETA NITROACRYLATE DERIVATIVE; CEFTAZIDIME;

ARTICLE; ATOM; CATALYSIS; CATALYST; CHEMICAL REACTION; ECOSYSTEM; ENERGY CONSUMPTION; ENVIRONMENTAL HEALTH; MICHAEL ADDITION; REACTION TIME; SYNTHESIS;

EID: 43049179701     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.04.076     Document Type: Article

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44. General procedure: Amine 1 (2 mmol) was added to β-nitroacrylate 2 (2 mmol), then the mixture was stirred at room temperature for the appropriate time (see Table 1), after this the crude product was directly charged on the head of the flash chromatography column and eluted by a mixture of hexane and ethyl acetate.