An Animal Model of Placental Insufficiency-Induced Intrauterine Growth Restriction

Seminars in Perinatology

Volumn 32, Issue 3, 2008, Pages 225-230

  Barry, James S ^a   Rozance, Paul J ^a   Anthony, Russell V ^a  

^a Perinatal Research Center   (United States)

Author keywords

fetal nutrient utilization; intrauterine growth restriction (IUGR); nutrient transfer; placenta; placental insufficiency; sheep

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

BLOOD OXYGENATION; CORONARY ARTERY BLOOD FLOW; DOPPLER FLOWMETRY; FETUS HEART RATE; FETUS HYPOXIA; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; NUTRIENT; NUTRIENT SUPPLY; OXYGEN AFFINITY; OXYGEN CONSUMPTION; OXYGEN SUPPLY; OXYGEN TRANSPORT; PANCREAS ISLET CELL; PLACENTA INSUFFICIENCY; PRIORITY JOURNAL; REVIEW; SHEEP; UMBILICAL CORD BLOOD FLOW; UTERUS BLOOD FLOW;

ANIMALS; ANOXIA; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; FEMALE; FETAL GROWTH RETARDATION; HUMANS; INSULIN; MATERNAL NUTRITION PHYSIOLOGY; OXYGEN; PLACENTAL CIRCULATION; PLACENTAL INSUFFICIENCY; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP;

EID: 43049176240     PISSN: 01460005     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semperi.2007.11.004     Document Type: Review

References (56)

1. Bernstein I.M., Horbar J.D., Badger G.J., et al. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network. Am J Obstet Gynecol 182 (2000) 198-206
2. Pardi G., and Cetin I. Human fetal growth and organ development: 50 years of discoveries. Am J Obstet Gynecol 194 (2006) 1088-1099
3. Battaglia F.C., Meschia G., Makowski E.L., et al. The effect of maternal oxygen inhalation upon fetal oxygenation. J Clin Invest 47 (1968) 548-555
4. Meschia G., Cotter J.R., Breathnach C.S., et al. The diffusibility of oxygen across the sheep placenta. Q J Exp Physiol Cogn Med Sci 50 (1965) 466-480
5. Leiser R., Krebs C., Ebert B., et al. Placental vascular corrosion cast studies: a comparison between ruminants and humans. Microsc Res Tech 38 (1997) 76-87
6. Anthony R.V., Scheaffer A.N., Wright C.D., et al. Ruminant models of prenatal growth restriction. Reproduction 61 (2003) 183-194 (suppl)
7. Regnault T.R., Galan H.L., Parker T.A., et al. Placental development in normal and compromised pregnancies. Placenta 23 (2002) S119-S129
8. Galan H.L., Hussey M.J., Barbera A., et al. Relationship of fetal growth to duration of heat stress in an ovine model of placental insufficiency. Am J Obstet Gynecol 180 (1999) 1278-1282
9. Thureen P.J., Trembler K.A., Meschia G., et al. Placental glucose transport in heat-induced fetal growth retardation. Am J Physiol 263 (1992) R578-R585
10. Bell A.W., Hay Jr. W.W., and Ehrhardt R.A. Placental transport of nutrients and its implications for fetal growth. J Reprod Fertil 54 (1999) 401-410 (suppl)
11. Pardi G., Cetin I., Marconi A.M., et al. Diagnostic value of blood sampling in fetuses with growth retardation. N Engl J Med 328 (1993) 692-696
12. de Vrijer B., Regnault T.R., Wilkening R.B., et al. Placental uptake and transport of ACP, a neutral nonmetabolizable amino acid, in an ovine model of fetal growth restriction. Am J Physiol 287 (2004) E1114-E1124
13. Carter A.M. Factors affecting gas transfer across the placenta and the oxygen supply to the fetus. J Dev Physiol 12 (1989) 305-322
14. Kingdom J., Huppertz B., Seaward G., et al. Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol 92 (2000) 35-43
15. Lee M.M., and Yeh M.N. Fetal microcirculation of abnormal human placenta. I. Scanning electron microscopy of placental vascular casts from small for gestational age fetus. Am J Obstet Gynecol 154 (1986) 1133-1139
16. Macara L., Kingdom J.C., Kohnen G., et al. Elaboration of stem villous vessels in growth restricted pregnancies with abnormal umbilical artery Doppler waveforms. Br J Obstet Gynecol 102 (1995) 807-812
17. Macara L., Kingdom J.C., Kaufmann P., et al. Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery Doppler waveforms. Placenta 17 (1996) 37-48
18. Regnault T.R., Orbus R.J., de Vrijer B., et al. Placental expression of VEGF. PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). Placenta 23 (2002) 132-144
19. Regnault T.R., de Vrijer B., Galan H.L., et al. The relationship between transplacental O2 diffusion and placental expression of PlGF. VEGF and their receptors in a placental insufficiency model of fetal growth restriction. J Physiol 550 (2003) 641-656
20. Carter A.M. Placental oxygen consumption. I. In vivo studies: a review. Placenta 21 (2000) S31-S37
21. Rudolph A.M. Distribution and regulation of blood flow in the fetal and neonatal lamb. Circ Res 57 (1985) 811-821
22. Sutton M.S., Theard M.A., Bhatia S.J., et al. Changes in placental blood flow in the normal human fetus with gestational age. Ped Res 28 (1990) 383-387
23. Galan H.L., Anthony R.V., Rigano S., et al. Fetal hypertension and abnormal Doppler velocimetry in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol 192 (2004) 272-279
24. Todros T., Sciarrone A., Piccoli E., et al. Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction. Obstet Gynecol 93 (1999) 499-503
25. Ferrazzi E., Rigano S., Bozzo M., et al. Umbilical vein blood flow in growth-restricted fetuses. Ultrasound Obstet Gynecol 16 (2000) 432-438
26. Harrington K., Fayyad A., Thakur V., et al. The value of uterine artery Doppler in the prediction of uteroplacental complications in multiparous women. Ultrasound Obstet Gynecol 23 (2004) 50-55
27. Konje J.C., Howarth E.S., Kaufmann P., et al. Longitudinal quantification of uterine artery blood volume flow changes during gestation in pregnancies complicated by intrauterine growth restriction. Br J Obstet Gynaecol 110 (2003) 301-305
28. Meschia G: Handbook of Physiology. The Cardiovascular System. American Physiology Society, 1984
29. Regnault T.R., de Vrijer B., Galan H.L., et al. Development and mechanisms of fetal hypoxia in severe fetal growth restriction. Placenta 28 (2007) 714-723
30. Baschat A.A., Gembruch U., Gortner L., et al. Coronary artery blood flow visualization signifies hemodynamic deterioration in growth-restricted fetuses. Ultrasound Obstet Gynecol 16 (2000) 425-431
31. Alexander B.T. Fetal programming of hypertension. Am J Physiol 290 (2006) R1-R10
32. Thornburg K.L., and Louey S. Fetal roots of cardiac disease. Heart 91 (2005) 867-868
33. Bell A.W., Kennaugh J.M., Battaglia F.C., et al. Metabolic and circulatory studies of fetal lamb at midgestation. Am J Physiol 250 (1986) E538-E544
34. BattagliaMeschia F.C., and Meschia G. An Introduction to Fetal Physiology (1986), Academic Press, Orlando, Florida
35. Barbera A., Galan H.L., Ferrazzi E., et al. Relationship of umbilical vein blood flow to growth parameters in the human fetus. Am J Obstet Gynecol 181 (1999) 174-179
36. Bellotti M., Pennati G., De Gasperi C., et al. Simultaneous measurements of umbilical venous, fetal hepatic, and ductus venosus blood flow in growth-restricted human fetuses. Am J Obstet Gynecol 190 (2000) 1347-1358
37. Kiserud T., Rasmussen S., and Skulstad S. Blood flow and the degree of shunting through the ductus venosus in the human fetus. Am J Obstet Gynecol 182 (2000) 147-153
38. Bonds D.R., Crosby L.O., Cheek T.G., et al. Estimation of human fetal-placental unit metabolic rate by application of the Bohr principle. J Dev Physiol 8 (1986) 49-54
39. Meschia G., Battaglia F.C., Hay W.W., et al. Utilization of substrates by the ovine placenta in vivo. Fed Proc 39 (1980) 245-249
40. Pardi G., Cetin I., Marconi A.M., et al. Venous drainage of the human uterus: respiratory gas studies in normal and fetal growth-retarded pregnancies. Am J Obstet Gynecol 166 (1992) 699-706
41. Economides D.L., and Nicolaides K.H. Blood glucose and oxygen tension levels in small-for-gestational-age fetuses. Am J Obstet Gynecol 160 (1989) 385-389
42. Nicolini U., Hubinont C., Santolaya J., et al. Maternal-fetal glucose gradient in normal pregnancies and in pregnancies complicated by alloimmunization and fetal growth retardation. Am J Obstet Gynecol 161 (1989) 924-927
43. Limesand S.W., Rozance P.J., Zerbe G.O., et al. Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology 147 (2006) 1488-1497
44. Anderson A.H., Fennessey P.V., Meschia G., et al. Placental transport of threonine and its utilization in the normal and growth-restricted fetus. Am J Physiol 272 (1997) E892-E900
45. Ross J.C., Fennessey P.V., Wilkening R.B., et al. Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol 270 (1996) E491-E503
46. Limesand S.W., Rozance P.J., Smith D., et al. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol 293 (2007) E17
47. Marconi A.M., Cetin I., Davoli E., et al. An evaluation of fetal glucogenesis in intrauterine growth-retarded pregnancies: metabolism. Clin Exp 42 (1993) 860-864
48. Bazaes R.A., Salazar T.E., Pittaluga E., et al. Glucose and lipid metabolism in small for gestational age infants at 48 hours of age. Pediatrics 111 (2003) 804-809
49. Setia S., Sridhar M.G., Bhat V., et al. Insulin sensitivity and insulin secretion at birth in intrauterine growth retarded infants. Pathology 38 (2006) 236-238
50. Barry J.S., Davidsen M.L., Limesand S.W., et al. Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction. Exp Biol Med 231 (2006) 566-575
51. Nicolini U., Hubinont C., Santolaya J., et al. Effects of fetal intravenous glucose challenge in normal and growth retarded fetuses. Horm Metab Res 22 (1990) 426-430
52. Nieto-Diaz Villar J., Matorras-Weinig R., et al. Intrauterine growth retardation at term: association between anthropometric and endocrine parameters. Acta Obstet Gynecol Scand 75 (1996) 127-131
53. Van Assche F.A., De Prins F., Aerts L., et al. The endocrine pancreas in small-for-dates infants. Brit J Obstet Gynecol 84 (1977) 751-753
54. Beringue F., Blondeau B., Castellotti M.C., et al. Endocrine pancreas development in growth-retarded human fetuses. Diabetes 51 (2002) 385-391
55. Vrijer W.B., Davidsen M.L., Wikening R.B., et al. altered placental and fetal expression of IGFs and IGF-binding proteins associated with intrauterine growth restriction in fetal sheep during early and mid-pregnancy. Pediatr Res 60 (2006) 507-512
56. Limesand S.W., Jensen J., Hutton J.C., et al. Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. Am J Physiol 288 (2005) R1297-R1305