HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias

European Journal of Cancer

Volumn 44, Issue 7, 2008, Pages 1015-1021

  Chiappetta, Gennaro ^a   Ferraro, Angelo ^b   Vuttariello, Emilia ^a   Monaco, Mario ^a   Galdiero, Francesca ^a   De Simone, Veronica ^a   Califano, Daniela ^a   Pallante, Pierlorenzo ^b   Botti, Gerardo ^a   Pezzullo, Luciano ^a   Pierantoni, Giovanna Maria ^b   Santoro, Massimo ^b   Fusco, Alfredo ^b,c  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Carcinoma; HMGA2; Thyroid carcinogenesis

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; FOLLICULAR CARCINOMA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PAPILLARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; THYROID ADENOMA;

EID: 43049117843     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.02.039     Document Type: Article

References (32)

1. R. Grosschedl K. Giese J. Pagel HMG domain proteins: architectural elements in the assembly of nucleoprotein structures Trends Genet 10 1994 94 100
2. R. Reeves M.S. Nissen The A-T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure J Biol Chem 265 1990 8573 8852
3. R. Reeves Structure and function of the HMGI(Y) family of architectural transcription factors Environ Health Perspect 108 2000 803 809
4. X. Zhou K.F. Benson H.R. Ashar K. Chada Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HHMGI-C Nature 376 1995 771 774
5. G. Chiappetta V. Avvantaggiato R. Visconti High level expression of the HMGA1 gene during embryonic development Oncogene 13 1996 2439 2446
6. S. Xiao M.L. Lux R. Reeves T.J. Hudson J.A. Fletcher HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma Am J Pathol 150 1997 901 910
7. M.T. Berlingieri G. Manfioletti M. Santoro Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells Mol Cell Biol 15 1995 1545 1553
8. M.T. Berlingieri G.M. Pierantoni V. Giancotti M. Santoro A. Fusco Thyroid cell transformation requires the expression of the HMGA1 proteins Oncogene 21 2002 2971 2980
9. S. Scala G. Portella M. Fedele G. Chiappetta A. Fusco Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias Proc Natl Acad Sci USA 97 2000 4256 4261
10. N. Abe T. Watanabe T. Masaki Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins Cancer Res 60 2000 3117 3122
11. N. Abe T. Watanabe Y. Izumisato Diagnostic significance of high mobility group I(Y) protein expression in intraductal papillary mucinous tumors of the pancreas Pancreas 25 2002 198 204
12. G. Chiappetta A. Bandiera M.T. Berlingieri The expression of the high mobility group HMGA1 proteins correlates with the malignant phenotype of human thyroid neoplasms Oncogene 10 1995 1307 1314
13. G. Chiappetta G. Tallini M.C. De Biasio Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma Cancer Res 58 1998 4193 4198
14. M. Fedele A. Bandiera G. Chiappetta Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins Cancer Res 56 1996 1896 1901
15. G. Chiappetta G. Manfioletti F. Pentimalli High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases Int J Cancer 91 2001 147 151
16. G. Chiappetta G. Botti M. Monaco HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression Clin Cancer Res 10 2004 7637 7644
17. N. Abe T. Watanabe Y. Izumisato High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms J Gastroenterol 12 2003 1144 1149
18. B. Meyer S. Loeschke A. Schultze HMGA2 overexpression in non-small cell lung cancer Mol Carcinog 46 7 2007 503 511
19. V. Masciullo G. Baldassarre F. Pentimalli HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas Carcinogenesis 24 2003 1191 1198
20. Y. Tamimi H.G. Vander Poel M.M. Denyn Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization Cancer Res 53 1993 5512 5516
21. J. Miyazawa A. Mitoro S. Kawashiri K.K. Chada K. Imai Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity Cancer Res 15 2004 2024 2029
22. Y.S. Rho Y.C. Lim I.S. Park High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma Acta Otolaryngol 127 1 2007 76 81
23. S. Obika D. Nanbu Y. Hari Synthesis of 2-O,4-C-methyleneuridine and cytidine. Novel bicyclic nucleosides having a fixed C3-endo sugar puckering Tetrahedron Letters 38 1997 8735 8738
24. A.A. Koshkin S.K. Singh P. Nielsen LNA (Locked nucleic acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil biocyclonucleoside monomers, oligomerisation and unprecedented nucleic acid recognition Tetrahedron 54 1998 3607 3630
25. TM- Expression profiling 99% of all human genes using only 90 dual-labeled real-time PCR Probes Bio Techniques 37 2004 492 495
26. P. Mouritzen M. Noerholm P.S. Nielsen ProbeLibrary: A new method for faster design and execution of quantitative real-time PCR Nature Methods 2 2005 313 316
27. −(Delta Delta C(T)) Method Methods 25 2001 402 408
28. S. Scala G. Portella D. Vitagliano HMGI-C gene expression is not required for in vivo thyroid cell transformation Carcinogenesis 22 2 2001 251 256
29. T. Wang X. Zhang L. Obijuru A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas Genes Chromosomes Cancer 46 4 2007 336 347
30. G. Belge A. Meyer M. Klemke Upregulation of HMGA2 in thyroid carcinomas: A novel molecular marker to distinguish between benign and malignant follicular neoplasias Genes Chromosomes Cancer 47 1 2007 56 63
31. J. Feilchenfeldt M. Totsch S.Y. Sheu Expression of galectin-3 in normal and malignant thyroid tissue by quantitative PCR and immunohistochemistry Mod Pathol 16 2003 117 123
32. M. Niedzela J. Maceluch E. Korman Galectin-3 is not a universal marker of malignancy in thyroid nodular disease in children and adolescents J Clin Endocrinol Metab 87 2002 4411 4415