Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 4860-4871

  Zhao, Yu ^a   Guo, Na ^a   Lou, Li Guang ^b   Cong, Yu Wen ^c   Peng, Li Yan ^a   Zhao, Qin Shi ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Cytotoxicity; Derivatives of taxchinin A and brevifoliol; SAR; Synthesis

Indexed keywords

13 OXO BREVIFOLIOL; 13 OXO TAXCHININ A; 5 OXO 13,15 EPOXY 13 EPI TAXCHININ A; 5,13 DIOXOTAXCHININ A; ANTINEOPLASTIC AGENT; BREVIFOLIOL; KETONE; PLANT EXTRACT; TAXCHININ A; TAXUS CHINENSIS EXTRACT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CISPLATIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TUMOR CELLS, CULTURED;

EID: 43049116489     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.041     Document Type: Article

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