Liquid chromatography-mass spectrometry and liquid chromatography-NMR characterization of in vitro metabolites of a potent and irreversible peptidomimetic inhibitor of rhinovirus 3C protease

Drug Metabolism and Disposition

Volumn 29, Issue 5, 2001, Pages 729-734

  Zhang, Kanyin E ^a,b   Brian, Hee ^a   Lee, Caroline A ^a   Liang, Baihong ^a   Potts, Barbara C M ^a,c  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Nereus Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; RUPINTRIVIR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROXYLATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE ENDOPEPTIDASES; DOGS; HAPLORHINI; HUMANS; ISOXAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PEPTIDES; PROTEASE INHIBITORS; PYRROLIDINONES; VIRAL PROTEINS;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS; RHINOVIRUS; RODENTIA;

EID: 0035029260     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Synthesis and properties of pyrrolin-2-ones
2. The Luffarins (A-Z), novel terpenes from an Australian marine sponge, Luffariella geometrica
3. Rhinoviruses
4. Experimental infection of chimpanzees with human rhinovirus type 14 and 43
5. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
6. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements
7. Structure-based design, synthesis, and biological evaluations of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies
8. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies
9. Pseudoesters and Derivatives. XXII. Synthesis of 5-hydroxy-3 pyrrolin-2-ones and 5-hydroxypyrrolidin-2-ones by ammonolysis of 5-melhoxyfuran-2 (5H)-ones and derivatives
10. Rhinovirus
11. Metabolism and pharmacokinetics of AG7088, a rhinovirus protease inhibitor in various species
12. Glutamine-derived aldehydes for the inhibition of human rhinovirus 3C protease
13. Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit viral replication
14. Stability of AG7088, a human rhinovirus 3C protease inhibitor, in plasma of different species
15. Viral proteinases
16. 1H NMR Spectroscopy
17. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease
18. The chemical mechanism of inactivation of bee venom phospholipase A2 by the marine natural products manoalide, luffariellolide, and scalaradial
19. Picornaviridae and their replication
20. Manoalide, an antibiotic sesterterpenoid from the marine sponge Luffariella variabilis (polejaeff)
21. WET solvent suppression and its applications to LC NMR and high-resolution NMR spectroscopy
22. Magic-angle-gradient double-quantum-filtered COSY
23. Dual inhibition of human rhinovirus 2A and 3C proteases by homophthalimides
24. Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease
25. Renin inhibitors containing conformationally restricted P1-P1′ dipeptide mimetics