Genetic contributions to influenza virus attenuation in the rat brain

Journal of NeuroVirology

Volumn 14, Issue 2, 2008, Pages 136-142

  Qi, Li ^a   Carbone, Kathryn M ^a   Ye, Zhiping ^a   Liu, Teresa ^a   Ovanesov, Mikhail ^b   Pletnikov, Mikhail ^b   Sauder, Christian ^a   Rubin, Steven A ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Attenuation; Influenza virus; Neurotoxicity; Rat

Indexed keywords

COMPLEMENTARY DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC ASSOCIATION; INFLUENZA; INFLUENZA VIRUS; MUTATIONAL ANALYSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE; TEMPERATURE SENSITIVITY; VIRUS ATTENUATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; CENTRAL NERVOUS SYSTEM; GENES, VIRAL; INFLUENZA A VIRUS; MUTAGENESIS, SITE-DIRECTED; ORTHOMYXOVIRIDAE INFECTIONS; RATS; TEMPERATURE; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE; RATTUS;

EID: 42949148067     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280701885563     Document Type: Article

References (37)

1. Brown, E. G. (2000) Influenza virus genetics. Biomed Pharmacother, 54, pp. 196-209.
2. de Jong, M. D., Bach, V. C., Phan, T. Q., Vo, M. H., Tran, T. T., Nguyen, B. H., Beld, M., Le, T. P., Truong, H. K., Nguyen, V. V., Tran, T. H., Do, Q. H. and Farrar, J. (2005) Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med, 352, pp. 686-691.
3. Dybing, J. K., Schultz-Cherry, S., Swayne, D. E., Suarez, D. L. and Perdue, M. L. (2000) Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses. J Virol, 74, pp. 1443-1450.
4. The European Agency for the Evaluation of Medicinal Products (2003) Points to consider on the development of live attenuated influenza vaccines
5. Frankova, V., Jirasek, A. and Tumov, B. (1977) Type A influenza: Postmortem virus isolations from different organs in human lethal cases. Arch Virol, 53, pp. 265-268.
6. Fujimoto, S., Kobayashi, M., Uemura, O., Iwasa, M., Ando, T., Katoh, T., Nakamura, C., Maki, N., Togari, H. and Wada, Y. (1998) PCR on cerebral spinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet, 352, pp. 873-875.
7. Gao, P., Watanabe, S., Ito, T., Goto, H., Wells, K., McGregor, M., Cooley, A. J. and Kawaoka, Y. (1999) Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J Virol, 73, pp. 3184-3189.
8. Govorkova, E. A., Rehg, J. E., Krauss, S., Yen, H. L., Guan, Y., Peiris, M., Nguyen, T. D., Hanh, T. H., Puthavathana, P., Long, H. T., Buranathai, C., Lim, W., Webster, R. G. and Hoffmann, E. (2005) Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol, 79, pp. 2191-2198.
9. Hatta, M., Gao, P., Halfmann, P. and Kawaoka, Y. (2001) Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science, 293, pp. 1840-1842.
10. Hoffmann, E., Neumann, G., Kawaoka, Y., Hobom, G. and Webster, R. G. (2000) A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci USA, 97, pp. 6108-6113.
11. International Association for Biologicals (2006) IABS scientific workshop on neurovirulence tests for live virus vaccines, January 31-February 1, 2005, Geneva. Biologicals, 34, pp. 233-236.
12. Jin, H., Lu, B., Zhou, H., Ma, C., Zhao, J., Yang, C. F., Kemble, G. and Greenberg, H. (2003) Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. Virology, 306, pp. 18-24.
13. Jin, H., Zhou, H., Lu, B. and Kemble, G. (2004) Imparting temperature sensitivity and attenuation in ferrets to A/Puerto Rico/8/34 influenza virus by transferring the genetic signature for temperature sensitivity from cold-adapted A/Ann Arbor/6/60. J Virol, 78, pp. 995-998.
14. Kim, W. G., Mohney, R. P., Wilson, B., Jeohn, G. H., Liu, B. and Hong, J. S. (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia. J Neurosci, 20, pp. 6309-6316.
15. Kristensson, K. (2006) Avian influenza and the brain-Comments on the occasion of resurrection of the Spanish flu virus. Brain Res Bull, 68, pp. 406-413.
16. Liu, B., Du, L. and Hong, J. S. (2000) Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther, 293, pp. 607-617.
17. Liu, T. and Ye, Z. (2002) Restriction of viral replication by mutation of the influenza virus matrix protein. J Virol, 76, pp. 13055-13061.
18. Liu, T. and Ye, Z. (2005) Attenuating mutations of the matrix gene of influenza A/WSN/33 virus. J Virol, 79, pp. 1918-1923.
19. Maassab, H. F. (1967) Adaptation and growth characteristics of influenza virus at 25 degrees c. Nature, 213, pp. 612-614.
20. Mase, M., Tanimura, N., Imada, T., Okamatsu, M., Tsukamoto, K. and Yamaguchi, S. (2006) Recent H5N1 avian influenza A virus increases rapidly in virulence to mice after a single passage in mice. J Gen Virol, 87, pp. 3655-3659.
21. McCullers, J. A., Facchini, S., Chesney, P. J. and Webster, R. G. (1999) Influenza B virus encephalitis. Clin Infect Dis, 28, pp. 898-900.
22. Mori, I. and Kimura, Y. (2001) Neuropathogenesis of influenza virus infection in mice. Microbes Infect, 3, pp. 475-479.
23. Mori, S., Nagashima, M., Sasaki, Y., Mori, K., Tabei, Y., Yoshida, Y., Yamazaki, K., Hirata, I., Ito, T. and Suzuki, S. (1999) A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997-1998 season in Tokyo. Arch Virol, 144, pp. 147-155.
24. Murphy, A. and Hawkes, R. (1970) Neurological complications of influenza A2/Hong Kong/68 virus. Med J Aust, 2, p. 511.
25. Nishimura, H., Itamura, S., Iwasaki, T., Kurata, T. and Tashiro, M. (2000) Characterization of human influenza A (H5N1) virus infection in mice: Neuro-, pneumo- and adipotropic infection. J Gen Virol, 81, pp. 2503-2510.
26. Ovanesov, M. V., Sauder, C., Rubin, S. A., Richt, J., Nath, A., Carbone, K. M. and Pletnikov, M. V. (2006) Activation of microglia by borna disease virus infection: In vitro study. J Virol, 80, pp. 12141-12148.
27. Park, C. H., Ishinaka, M., Takada, A., Kida, H., Kimura, T., Ochiai, K. and Umemura, T. (2002) The invasion routes of neurovirulent A/Hong Kong/ 483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice. Arch Virol, 147, pp. 1425-1436.
28. Reinacher, M., Bonin, J., Narayan, O. and Scholtissek, C. (1983) Pathogenesis of neurovirulent influenza A virus infection in mice. Lab Invest, 49, pp. 686-692.
29. Rose, E. and Prabhakar, P. (1982) Influenza A virus associated neurological disorders in Jamaica. WI Med J, 31, pp. 29-33.
30. Rubin, S., Liu, D., Pletnikov, M., McCullers, J., Ye, Z., Levandowski, R., Johannessen, J. and Carbone, K. (2004) Wild-type and attenuated influenza virus infection of the neonatal rat brain. J NeuroVirol, 10, pp. 305-314.
31. Scholtissek, C., Vallbracht, A., Flehmig, B. and Rott, R. (1979) Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurovirulent parent virus strains. Virology, 95, pp. 492-500.
32. Shinya, K., Hamm, S., Hatta, M., Ito, H., Ito, T. and Kawaoka, Y. (2004) PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology, 320, pp. 258-266.
33. Shortridge, K. F., Zhou, N. N., Guan, Y., Gao, P., Ito, T., Kawaoka, Y., Kodihalli, S., Krauss, S., Markwell, D., Murti, K. G., Norwood, M., Senne, D., Sims, L., Takada, A. and Webster, R. G. (1998) Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology, 252, pp. 331-342.
34. Subbarao, E. K., London, W. and Murphy, B. R. (1993) A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol, 67, pp. 1761-1764.
35. Suguitan Jr., A. L., McAuliffe, J., Mills, K. L., Jin, H., Duke, G., Lu, B., Luke, C. J., Murphy, B., Swayne, D. E., Kemble, G. and Subbarao, K. (2006) Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets. PLoS Med, 3, p. e360.
36. Takahashi, M., Yamada, T., Nakashita, Y., Saikusa, H., Deguchi, M., Kida, H., Tashiro, M. and Toyoda, T. (2000) Influenza virus-induced encephalopathy: Clinicopathologic study of an autopsied case. Pediatr Int, 42, pp. 204-214.
37. Thraenhart, O., Schley, G. and Kuwert, E. (1975) Isolation of influenza virus A/Hong Kong/1/68 (H3N2) from liquor cerebrospinalis of patients with CNS involvement. Med Klin, 70, pp. 1910-1914.