Artemisinin - An innovative cornerstone for anti-malaria therapy

Progress in Drug Research

Volumn 66, Issue , 2008, Pages 383-422

  Thomas, Kuhn ^a   Ying, Wang ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIMONIA PILOSA EXTRACT; ANTIMALARIAL AGENT; ARTABOTRYS HEXAPETALU EXTRACT; ARTEETHER; ARTEMETHER; ARTEMETHER PLUS BENFLUMETOL; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; ARTESUNATE; ARTESUNATE PLUS AYRONARIDINE; BENFLUMETOL; BRUCEA JAVANICA EXTRACT; CHLOROQUINE; CHLORPROGUANIL PLUS DAPSONE; DICHROA FEBRIFUGA EXTRACT; DIHYDROARTEMISININ PLUS PIPERAQUINE; EUCALYPTUS ROBUSTA EXTRACT; FANSIDAR; MEFLOQUINE; NANDINA DOMESTICA EXTRACT; OZ 227; PIPERAQUINE; PLANT EXTRACT; POLYALTHIA NEMORALIS EXTRACT; UNCLASSIFIED DRUG; ARTEMETHER LUMEFANTRINE COMBINATION; ARTEMETHER-LUMEFANTRINE COMBINATION; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; HERBACEOUS AGENT;

AGRIMONIA; AGRIMONIA PILOSA; ANTIMALARIAL ACTIVITY; ARTABOTRYS HEXAPETALU; ARTEMISIA ANNUA; BRUCEA; BRUCEA JAVANICA; CHINESE MEDICINE; CLINICAL TRIAL; DICHROA FEBRIFUGA; DISEASE TRANSMISSION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG ISOLATION; DRUG MANUFACTURE; DRUG MARKETING; DRUG MECHANISM; DRUG METABOLISM; DRUG PURIFICATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; EUCALYPTUS; EUCALYPTUS ROBUSTA; EVERGREEN; HUMAN; MALARIA; MEDICAL SOCIETY; MEDICINAL PLANT; NANDINA DOMESTICA; POLYALTHIA; POLYALTHIA NEMORALIS; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOMASS; CHEMICAL STRUCTURE; CHEMISTRY; CROP; DRUG COMBINATION; DRUG DESIGN; DRUG RESISTANCE; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; PHARMACEUTICS; TREATMENT OUTCOME;

ANIMALS; ANTIMALARIALS; ARTEMISIA ANNUA; ARTEMISININS; BIOMASS; CROPS, AGRICULTURAL; DRUG COMBINATIONS; DRUG DESIGN; DRUG RESISTANCE; DRUGS, CHINESE HERBAL; ETHANOLAMINES; FLUORENES; HUMANS; MALARIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TECHNOLOGY, PHARMACEUTICAL; TREATMENT OUTCOME;

EID: 42949144997     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7643-8595-8_9     Document Type: Review

References (39)

1. www.nobelprice.org
2. www.rollbackmalaria.org
3. www.theglobalfund.org
4. Butler A, Hensman T (2000) Drugs for the fevel. Educ Chem 37(6): 151
5. Editorial Office (2007) Chinese inventors who saved the lives of 500 million people. Global People 25(5): 15-16
6. Li Y, Wu Y (2003) An over four millennium story behind qinghaosu (artemisinin) - a fantastic antimalarial drug from a traditional Chinese herb. Curr Med Chem 10: 2197-2230
7. Lu Y (2007) Tu Youyou, changing the world with a medicinal plant. Global People 25(5): 17-18
8. Hsu E (2006) Reflections on the 'discovery' of the antimalarial qinghao. Br J Clin Pharmacol 66(6): 666-670
9. Charles D, Cebert E, Simon J (1991) Characterization of the essential oils of Artemisia annua L. J Ess Oil Res 3: 33-39
10. Woerdenbag H, Pras N, Chan N, Bang B, Bos R, van Uden W, Van PY, Boi N, Batterman S, Lugt C (1994) Artemisinin, related sesquiterpenes, and essential oil in Artemisia annua during a vegetation period in Vietnam. Planta Med 60: 272-275
11. Coordinating Group for Research on the Structure of Qing Hau Su (1977) Coordination research on the structure of qinghaosu. Kexue Tongbao (Chinese Edition) 22(3): 142
12. Haynes R (2006) From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. Curr Topics Med Chem 6: 509-537
13. Delabays N, Simonnet X, Gaudin M (2001) The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Curr Med Chem 8: 1795-1801
14. Delabays N (1997) Biologie de la reproduction chez l'Artemisia annua L. et génétique de la production en artémisinine - Contribution à la domestication et à l'amélioration génétique de l'espèce. Thèse de doctorat. Faculté des Sciences de l'Université de Lausanne
15. Acton N, Klayman D, Rollman I (1985) Reductive electrochemical HPLC assay for artemisinin (qinghaosu). Planta Med 51: 445-446
16. Goozner M (2006) Beating malaria. The Scientist 20(12): 31
17. Robert A, Coppel Y, Meunier B (2002) Alkylation of heme by the antimalarial drug artemisinin. Chem Com 5: 414-415
18. Efferth T, Davey M, Olbrich A, Rucker G, Gebhart E, Davey R (2002) Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. Blood Cells Mol Dis 28(2): 160-168
19. Schmid G, Hofheinz W (1983) Total synthesis of qinghaosu. J Am Chem Soc 105: 624-625
20. Acton N, Roth R (1992) On the conversion of dihydroartemisinic acid into artemisinin. J Org Chem 57: 3610-3614
21. Lapkin A, Plucinski P, Cuthler M (2006) Comparative assessment of technologies for extraction of artemisinin. J Nat Prod 69: 1653-1664
22. www.who.int/medicines/publications/essentialmedicines/en/index.html
23. Thayer A (2005) Fighting malaria. Chem Eng News 83(43): 69-82
24. Rosenthal P (2003) Antimalarial drug discovery: old and new approaches. J Exp Biol 206: 3735-3744
25. Olliaro P, Taylor W (2004) Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria. J Postgrad Med 50: 40-44
26. www.malariaandhealth.com
27. www.mediplant.ch
28. Kumar S, Gupta S, Singh P, Bajpai P, Gupta M, Singh D, Gupta A, Ram G, Shasany A, Sharma S (2004) High yields of artemisinin by multi-harvest of Artemisia annua crops. Ind Crops and Prod 19: 77-90
29. Duke S, Vaughn K, Croom Jr E, Elsohly H (1987) Artemisinin, a constituent of annual wormwood (A. annua), is a selective phytotoxin. Weed Sci 35: 499-505
30. Chen P, Leather G, Klayman D (1987) Allelopathic effect of artemisinin and its related compounds from A. annua. Plant Physiol 83: 406
31. Namdeo A, Mahadik K, Kadam S (2006) Antimalaria drug - Artemisia annua. Pharmacognosy Magazine 2 (6): 106-111
32. Roth R, Acton N (1989) A simple conversion of artemisinic acid into artemisinin. J Nat Prod 52 (5): 1183-1185
33. Jung M, ElSohly H, Croom Jr E (1986) Practical conversion of artemisinic acid into desoxyartemisinin. J Org Chem 51: 5417-5419
34. Covello P, Teoh K, Polichuk D, Reed D, Nowak G (2007) Functional genomics and the biosynthesis of artemisinin. Phytochemistry 68 (14): 1864-1871
35. www.who.int/medicines/publications/pharmacopoeia/overview/en/index.html
36. www.bundesrecht.juris.de/aflatoxinverbotsv/
37. Ro D, Paradise E, Ouellet M, Fisher K, Newman K, Ndungu J, Ho K, Eachus R, Ham R, Kirby J et al (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440: 940-943
38. Boehm M, Fünfschilling P, Krieger M, Kuesters E, Struber F (2007) An improved manufacturing process for the antimalaria drug Coartem, Part 1. Org Process R&D 11: 336-340
39. Beutler U, Fünfschilling P, Steinkemper A (2007) An improved manufacturing process for the antimalaria drug Coartem, Part 2. Org Process R&D 11: 341-345