Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Case of drug interaction?

Acta Gastro-Enterologica Belgica

Volumn 71, Issue 1, 2008, Pages 36-38

  Etogo Asse, F ^a   Boemer, F ^a   Sempoux, C ^a   Geubel, A ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Cholestasis; Hypericum perforatum; St. John's wort; Vanishing bile duct syndrome

Indexed keywords

HYDROXYCHLOROQUINE SULFATE; HYPERICUM PERFORATUM EXTRACT; TIBOLONE; URSODEOXYCHOLIC ACID;

ADULT; APPETITE; ARTICLE; CASE REPORT; CHOLESTATIC HEPATITIS; DARK URINE; DEPRESSION; DRUG WITHDRAWAL; FATIGUE; FEMALE; HEPATOMEGALY; HUMAN; HUMAN TISSUE; HYPERICUM PERFORATUM; INTRAHEPATIC BILE DUCT; JAUNDICE; LIVER BIOPSY; LIVER INJURY; MENOPAUSAL SYNDROME; PRURITUS; RHEUMATOID ARTHRITIS; SIDE EFFECT;

ANDROGEN ANTAGONISTS; BILE DUCTS, INTRAHEPATIC; CHOLESTASIS; DRUG INTERACTIONS; FEMALE; HEPATITIS, TOXIC; HUMANS; HYPERICUM; MIDDLE AGED; NORPREGNENES; POSTMENOPAUSE;

EID: 42949142612     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. DURR D., STIEGER B., KULLAK-UBLICK G.A., RENTSCH K., STEINERT H.C., MEIER P.J et al. St. John's wort induces intestinal P-glycoprotein/MD R1 and intestinal and hepatic CYP3A4. Clin. Pharmacol. Ther., 2000, 68 : 598.
2. PISCITELLI S.C., BURSTEIN A.H., CHAITT D., ALFARO R.M., FALLOON J. Indinavir concentrations and St. John's wort. Lancet, 2000 (9203), 355 : 547-548.
3. KARLIOVA M., TREICHEL U., MALAGO M., FRILLING A., BROELSCH C.E. Interaction of Hypericum perforatum (St. John's wort) with cyclosporin A metabolism in a patient after liver transplantation. J. Hepatol., 2000, 33 : 853-855.
4. BARONE G.W., GURLEY B.J., KETEL B.L., ABUL-EZZ S.R. Herbal supplements : a potential for drug interactions in transplant recipients. Transplantation, 2001 ;71(2) :239-241.
5. NEBEL A., SCHNEIDER B.J., BAKER R.K., KROLL D.J. Potential metabolic interaction between St. John's wort and theophylline [letter]. Ann. Pharmacother., 1999, 33 (4) : 502.
6. HARPUTLUOGLU M.M., DEMIREL U., KARADAG N., KARAHAN D., ALADAG M., KARINCAOGLU M., HILMIOGLU F. Severe hepatitis with prolonged cholestasis and bile duct injury due the long-term use of ornidazole. Acta Gastroenterol. Belg., 2007 Jul-Sep, 70 (3) : 293-5.
7. DEMIRAG M.D., OZENIRLER S., GOKER B., POYRAZ A., HAZNEDAROGLU S., OZTURK M.A. Idiosyncratic toxic hepatitis secondary to single dose of naproxen. Acta Gastroenterol. Belg., 2007 Apr-Jun, 70 (2) : 247-8.
8. SONMEZ A., YILMAZ M.I., MAS R., OZCAN A., CELASUN B., DOGRU T., TASLIPINAR A., KOCAR I.H. Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation. Acta Gastroenterol. Belg., 2005 Jul-Sep, 68 (3) : 385-7.
9. SCHEUER P.J, LEFKOWITCH J.H. Liver biopsy interpretation. 1994, fifth edition. W.B. Saunders Company Ltd, London Philadelphia Toronto Sydney Tokyo, p. 304.
10. ROSKAMS T.A., THEISE N.D., BALABAUD C., BHAGAT G., BATHAL P.S., BIOULAC-SAGE P. et al. Nomenclature of the finer branches of the biliary tree : canals, ductules, and ductular reactions in human livers. Hepatol., 2004, 39 (6) : 1739-1745.
11. GREGORETTI B., STEBEL M., CANDUSSIO L., CRIVELLATO E., BARTOLI F., DECORTI G. Toxicity of Hypericum perforatum (St. John's Wort) administered during pregnancy and lactation in rats. Toxicol. Applied Pharmacol. 2004, 200 : 201-205.
12. GRUSH L.R., NIERENBERG A., KEEFE B., COHEN L.S. St. John's Wort during pregnancy. JAMA, 1998, 280 : 1566.
13. MOORE L.B., GOODWIN B., JONES S.A., WISELY G.B., SERABJIT-SINGH C.J., WILLSON T.M., COLLINS J.L., KLIEWER S.A. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. PNAS, 2000, 97 : 7500-7502.
14. BRAY B.J., PERRY N.B., MENKES D.B ., ROSENGREN R.J. Toxicol. St. John's Wort extract induces CYP3A and CYP2E1 in the swiss webster mouse. Toxicol., 2002, 66 : 27-33.
15. BLANCO SAMPASCUAL S., DE LAS HERAS NINO B., CABEZUDO GIL P., RUIZ EGUILUZ P., ORIVE CURA V. Tibolone-induced hepatotoxicity. Gastroenterol. Hepatol., 2002, 25 : 274.
16. VERHOEVEN C.H., VOS R.M., DELBRESSINE L.P. The in vivo metabolism of tibolone in animal species. Eur. J. Drug Metab. Pharmacokinet., 2002, 27: 1-10.