The in vivo metabolism of tibolone in animal species

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 1, 2002, Pages 1-10

  Verhoeven, C H J ^a   Vos, R M E ^a   Delbressine, L P C ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Animals; Metabolism; Metabolites; Pharmacokinetics; Tibolone

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; TIBOLONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG CONJUGATION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG FORMULATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FEMALE; IN VIVO STUDY; NONHUMAN; RABBIT; RAT; REDUCTION; SPECIES DIFFERENCE;

EID: 0036209501     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190399     Document Type: Article

References (15)

1. Livial: A review of clinical studies
2. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: Analysis of interspecies variability and comparison with metabolism in vivo
3. Clinical profile of Org OD14
4. Mass spectrometry of basic aluminium sucrose octasulphate using fast atom bombardment with a saturated tetramethylammonium ion sample matrix
5. Fast atom bombardment mass spectrometry of sulphated metabolites of the steroid Org OD 14 using a glycerol matrix saturated with tetramethylammonium hydroxide
6. 5(10)estrene to the 3α-hydroxy epimer
7. In vitro and in vivo metabolism of desogestrel in several species
8. In vitro and in vivo metabolism of the progestagen Org 30659 in several species
9. Molecular structure of rat hepatic 3α-hydroxysteroid dehydrogenase
10. 5-steroid dehydrogenase and steroid delta-isomerase: Evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity
11. Partial characterization of the cytosol 3α-hydroxysteroid: NAD(P)+oxidoreductase of rat ventral prostate
12. Purification and properties of human hepatic 3α-hydroxysteroid dehydrogenase
13. Indomethacin-sensitive 3α-hydroxysteroid dehydrogenase in rat tissues
14. Intracrinology: The secret of the tissue-specificity of tibolone
15. Endocrinological studies with (7α, 17α-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD14)