Synthesis and pharmacological profile of a series of 1-substituted-2-carbonyl derivatives of diphenidol: Novel M4 muscarinic receptor antagonists

Medicinal Chemistry

Volumn 4, Issue 2, 2008, Pages 121-128

  Varoli, Lucilla ^a   Angeli, Piero ^b   Buccioni, Michela ^b   Burnelli, Silvia ^a   Fazio, Nicola ^a   Marucci, Gabriella ^b   Recanatini, Maurizio ^a   Spampinato, Santi ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Binding studies; cAMP; Diphenidol derivatives; Functional studies; Muscarinic antagonists; Subtype selectivity

Indexed keywords

1 BENZYLOXY 1,1 DIPHENYL 4 PIPERIDIN 1 YLBUTAN 2 ONE; 1 BENZYLOXY 1,1 DIPHENYLPROPAN 2 ONE; 1 BENZYLSULFANYL 1,1 DIPHENYL 4 PIPERIDIN 1 YLBUTAN 2 ONE; 1 BENZYLSULFANYL 1,1 DIPHENYLPROPAN 2 ONE; 1 ISOBUTOXY 1,1 DIPHENYL 4 PIPERIDIN 1 YLBUTAN 2 ONE; 1 ISOBUTOXY 1,1 DIPHENYLPROPAN 2 ONE; 1 ISOPROPOXY 1,1 DIPHENYL 4 PIPERIDIN 1 YLBUTAN 2 ONE; 1 ISOPROPOXY 1,1 DIPHENYLPROPAN 2 ONE; 1 THIOPEN 3 YL 1,1 DIPHENYL 4 PIPERIDIN 1 YLBUTAN 2 ONE; 1,1 DIPHENYL 1 THIOPEN 3 YL PROPAN 2 ONE; 1,2 DIPHENYL 1 THIOPEN 3 YL PROPANE 1,2 DIOL; 2 HYDROXY 1,2 DIPHENYL 2 THIOPEN 3 YL ETHANONE; CARBACHOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; DIFENIDOL; FORSKOLIN; MUSCARINIC M4 RECEPTOR; MUSCARINIC M4 RECEPTOR BLOCKING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GEL CHROMATOGRAPHY; HUMAN; MALE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG ANTAGONISM; GUINEA PIG; HAMSTER; RABBIT; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GUINEA PIGS; MUSCARINIC ANTAGONISTS; PIPERIDINES; RABBITS; RECEPTOR, MUSCARINIC M4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42949136115     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608783789211     Document Type: Article

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