Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome?

Human Reproduction

Volumn 14, Issue 6, 1999, Pages 1435-1439

  Petermann, T ^a,g   Piwonka, V ^b   Perez F ^c   Maliqueo, M ^d   Recabarren, S E ^e   Wildt, L ^f  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c Laboratory of Animal Physiology and Endocrinology   (Germany)

^d UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^e UNIVERSITY OF CONCEPCIÓN   (Chile)

^f UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^g NONE   (Chile)

Author keywords

Leptin; LH; Polycystic ovarian syndrome; Pulsatility; Synchronicity

Indexed keywords

FOLLITROPIN; GONADORELIN; LEPTIN; LUTEINIZING HORMONE;

ADULT; ALGORITHM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LUTEINIZING HORMONE BLOOD LEVEL; MENSTRUAL CYCLE; MOLECULAR INTERACTION; OVARY POLYCYSTIC DISEASE; PROTEIN BLOOD LEVEL;

EID: 0033029531     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/14.6.1435     Document Type: Article

References (33)

1. Adams, J., Poison, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355-359.
2. Ahima, R., Prabakaran, D., Mantzoros, C. et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature, 382, 250-252.
3. Albers, N., Bettendorf, M., Herrmann, H. et al. (1993) Hormone ontogeny in thé ovine fétus. XXVII. Pulsatile and copulsatile secretion of luteinizing hormone, follicle-stimulating hormone, growth hormone, and prolactin in late gestation: a new method for the analysis of copulsatility. Endocrinology, 132, 701-709.
4. Barash, I.A., Cheung, C.C., Weigle, D.S. et al. (1996) Leptin is a metabolic signal to the reproductive system. Endocrinology, 137, 3144-3147.
5. Chapman, I., Wittert, G. and Norman, R. (1997) Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin. Endocrinol., 46, 175-181.
6. Chehab, F., Lim, M. and Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with recombinant human leptin. Nature Genet., 12, 318-320.
7. Cioffi, J.A., Van Blerkom, J., Antczak, M. et al. (1997) The expression of leptin and its receptors in pre-ovulatory human follicles. Mol. Hum. Reprod., 3, 467-472.
8. Dunaif, A., Segal, K.R., Futterweit, W. et al. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
9. Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
10. Geisthövel, F., Meysing, A. and Brabant, G. (1998) C-peptide and insulin, but not C+-steroids, support the predictive value of body mass index on leptin in serum of premenopausal women. Hum. Reprod., 13, 547-553.
11. Gennarelli, G., Holte, J., Wide, L. et al. (1998) Is there a role for leptin in the endocrine and metabolic aberrations of polycystic ovary syndrome. Hum. Reprod., 13, 535-541.
12. Hardie, L., Trayhurn, P., Abramovich, D. and Fowler, P. (1997) Circulating leptin in women: a longitudinal study in the menstrual cycle during pregnancy, Clin. Endocrinol., 47, 101-106.
13. Karlsson, C., Lindell, K., Svensson, E. et al. (1997) Expression of functional leptin receptors in the human ovary. J. Clin. Endocrinol. Metab., 82, 4144-4148.
14. Klein, S., Coppack, S.W., Mohamed-Ali, V. and Landt, M. (1996) Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes, 45, 984-987.
15. Laughlin, G.A., Morales, A.J. and Yen, S.S.C. (1997) Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J. Clin. Endocrinol. Metab., 82, 1692-1696.
16. Licinio, J., Negrao, A.B., Mantzoros, C. et al. (1998) Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Med. Sci., 95, 2541-2546.
17. Mantzoros, C., Dunaif, A. and Flier, J. (1997) Leptin concentrations in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 82, 1687-1691.
18. Messinis, I. E., Milingos, S., Zikopoulos, K. et al. (1998) Leptin concentrations in the follicular phase of spontaneous cycles superovulated with follicle stimulating hormone. Hum. Reprod., 13, 1152-1156.
19. Palmen, M.R., Radovick, S. and Boepple, P.A. (1998) The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J. Clin. Endocrinol. Metab., 83, 1091-1096.
20. Pearson, E.S. and Clopper, C.J. (1934) The use of confidence or fiducial limits illustrated in the case of binomial. Biomelrika, 26, 701-709.
21. Poretsky, L. and Piper, B. (1994) Insulin resistance hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome. Obstet. Gynecol, 84, 613-621.
22. Rouro, J., Antilla, L., Koskinen, P. et al. (1997) Serum leptin concentrations in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 82, 1697-1700.
23. Rosenbaum, M. and Leibel, R.L. (1998) Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility. TEM, 9, 117-124.
24. Rosenbaum, M., Nicolson, M., Hirsch, J. et al. (1996) Effect of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol. Metab., 81, 3424-3427.
25. Saad, M., Damani, S., Gingerich, R.L. et al. (1997) Sexual dimorphism in plasma leptin concentration. J. Clin. Endocrinol. Metab., 82, 579-584.
26. Santen, R.J. and Bardin, C.W. (1973) Episodic lueteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms. J. Clin. Invest., 52, 2617-2628.
27. Sir-Petermann, T., Recabarren, S.E., Bittl, A. et al. (1995) A simple device for serial blood collection in human subjects and animals. Exp. Clin. Endocrinol., 138, 398-401.
28. Spicer, L. and Francisco, C. (1997) The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology, 138, 3374-3379.
29. Stephens, T.W., Basinski, M., Bristow, P.K. et al. (1995) The role of neuropeptide Y in the antiobesity action of obese gene product. Nature, 377, 530-532.
30. Veldhuis, J.D. and Johnson, M.L. (1986) Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. Am. J. Physiol., 250, E486-493.
31. Yu, W.H., Kimura., Walczewska, A. et al (1997a) Role of leptin in hypothalamic-pituitary function. Proc. Natl Acad. Sci. USA, 94, 1023-1028.
32. Yu, W.H., Walczewska, A., Karanth, S. and McCann, S. (1997b) Nitric oxide mediates leptin-induced lutîinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. Endocrinology, 138, 5055-5058.
33. Zhang, F., Proenca, R., Maffei, M. et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.