Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1782, Issue 5, 2008, Pages 335-340

  Nikles, Daphne ^a   Vana, Karen ^a   Gauczynski, Sabine ^a   Knetsch, Heike ^a   Ludewigs, Heike ^a   Weiss, Stefan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cancer; Heterochromatin; Laminin receptor; LRP LR; Prion protein; PrP; Subcellular localization

Indexed keywords

FLUORESCENT DYE; LAMININ RECEPTOR; PRION PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HETEROCHROMATIN; INTRACELLULAR SPACE; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANIMALS; CELL COMPARTMENTATION; CELL LINE; CELL NUCLEUS; CLONING, MOLECULAR; HETEROCHROMATIN; LUMINESCENT PROTEINS; MICE; MOLECULAR WEIGHT; MUTANT PROTEINS; PRIONS; PROTEIN TRANSPORT; RECEPTORS, LAMININ; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS;

EID: 42749095169     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2008.02.003     Document Type: Article

References (39)

1. Prusiner S.B. Novel proteinaceous infectious particles cause scrapie. Science 216 (1982) 136-144
2. Castilla J., Saa P., Hetz C., and Soto C. In vitro generation of infectious scrapie prions. Cell 121 (2005) 195-206
3. Legname G., Baskakov I.V., Nguyen H.O., Riesner D., Cohen F.E., DeArmond S.J., and Prusiner S.B. Synthetic mammalian prions. Science 305 (2004) 673-676
4. Bueler H., Fischer M., Lang Y., Bluethmann H., Lipp H.P., DeArmond S.J., Prusiner S.B., Aguet M., and Weissmann C. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356 (1992) 577-582
5. Bragason B.T., and Palsdottir A. Interaction of PrP with NRAGE, a protein involved in neuronal apoptosis. Mol. Cell. Neurosci. 29 (2005) 232-244
6. Hajj G.N., Lopes M.H., Mercadante A.F., Veiga S.S., da Silveira R.B., Santos T.G., Ribeiro K.C., Juliano M.A., Jacchieri S.G., Zanata S.M., and Martins V.R. Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins. J. Cell Sci. 120 (2007) 1915-1926
7. Krebs B., Wiebelitz A., Balitzki-Korte B., Vassallo N., Paluch S., Mitteregger G., Onodera T., Kretzschmar H.A., and Herms J. Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide. J. Neurochem. 100 (2007) 358-367
8. Li A., Piccardo P., Barmada S.J., Ghetti B., and Harris D.A. Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice. EMBO J. 26 (2007) 2777-2785
9. Mitteregger G., Vosko M., Krebs B., Xiang W., Kohlmannsperger V., Nolting S., Hamann G.F., and Kretzschmar H.A. The role of the octarepeat region in neuroprotective function of the cellular prion protein. Brain Pathol. 17 (2007) 174-183
10. Morel E., Fouquet S., Chateau D., Yvernault L., Frobert Y., Pincon-Raymond M., Chambaz J., Pillot T., and Rousset M. The cellular prion protein PrPc is expressed in human enterocytes in cell-cell junctional domains. J. Biol. Chem. 279 (2004) 1499-1505
11. Paitel E., Sunyach C., Alves da Costa C., Bourdon J.C., Vincent B., and Checler F. Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels. J. Biol. Chem. 279 (2004) 612-618
12. Barmada S., Piccardo P., Yamaguchi K., Ghetti B., and Harris D.A. GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol. Dis. 16 (2004) 527-537
13. Barmada S.J., and Harris D.A. Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein. J. Neurosci. 25 (2005) 5824-5832
14. Gu Y., Verghese S., Mishra R.S., Xu X., Shi Y., and Singh N. Mutant prion protein-mediated aggregation of normal prion protein in the endoplasmic reticulum: implications for prion propagation and neurotoxicity. J. Neurochem. 84 (2003) 10-22
15. Hachiya N.S., Watanabe K., Yamada M., Sakasegawa Y., and Kaneko K. Anterograde and retrograde intracellular trafficking of fluorescent cellular prion protein. Biochem. Biophys. Res. Commun. 315 (2004) 802-807
16. Magalhaes A.C., Silva J.A., Lee K.S., Martins V.R., Prado V.F., Ferguson S.S., Gomez M.V., Brentani R.R., and Prado M.A. Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein. J. Biol. Chem. 277 (2002) 33311-33318
17. Lee K.S., Magalhaes A.C., Zanata S.M., Brentani R.R., Martins V.R., and Prado M.A. Internalization of mammalian fluorescent cellular prion protein and N-terminal deletion mutants in living cells. J. Neurochem. 79 (2001) 79-87
18. Crozet C., Vezilier J., Delfieu V., Nishimura T., Onodera T., Casanova D., Lehmann S., and Beranger F. The truncated 23-230 form of the prion protein localizes to the nuclei of inducible cell lines independently of its nuclear localization signals and is not cytotoxic. Mol. Cell. Neurosci. 32 (2006) 315-323
19. Derrington E., Gabus C., Leblanc P., Chnaidermann J., Grave L., Dormont D., Swietnicki W., Morillas M., Marck D., Nandi P., and Darlix J.L. PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1. C. R. Biol. 325 (2002) 17-23
20. Vana K., Zuber C., Nikles D., and Weiss S. Novel aspects of prions, their receptor molecules, and innovative approaches for TSE therapy. Cell. Mol. Neurobiol. 27 (2007) 107-128
21. Gauczynski S., Peyrin J.M., Haik S., Leucht C., Hundt C., Rieger R., Krasemann S., Deslys J.P., Dormont D., Lasmezas C.I., and Weiss S. The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J. 20 (2001) 5863-5875
22. Gauczynski S., Nikles D., El-Gogo S., Papy-Garcia D., Rey C., Alban S., Barritault D., Lasmezas C.I., and Weiss S. The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes. J. Infect. Dis. 194 (2006) 702-709
23. Morel E., Andrieu T., Casagrande F., Gauczynski S., Weiss S., Grassi J., Rousset M., Dormont D., and Chambaz J. Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor. Am. J. Pathol. 167 (2005) 1033-1042
24. Ludewigs H., Zuber C., Vana K., Nikles D., Zerr I., and Weiss S. Therapeutic approaches for prion disorders. Expert Rev. Anti Infect. Ther. 5 (2007) 613-630
25. Zuber C., Ludewigs H., and Weiss S. Therapeutic approaches targeting the prion receptor LRP/LR. Vet. Microbiol. 123 (2007) 387-393
26. Zuber C., Knackmuss S., Rey C., Reusch U., Rottgen P., Frohlich T., Arnold G.J., Pace C., Mitteregger G., Kretzschmar H.A., Little M., and Weiss S. Single chain Fv antibodies directed against the 37 kDa/67 kDa laminin receptor as therapeutic tools in prion diseases. Mol. Immunol. 45 (2008) 144-151
27. Zuber C., Mitteregger G., Pace C., Kretzschmar H.A., Zerr I., and Weiss S. Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in scrapie infected mice. Prion 1 (2007) 207-212
28. Leucht C., Simoneau S., Rey C., Vana K., Rieger R., Lasmezas C.I., and Weiss S. The 37 kDa/67 kDa laminin receptor is required for PrP(Sc) propagation in scrapie-infected neuronal cells. EMBO Rep. 4 (2003) 290-295
29. Vana K., and Weiss S. A trans-dominant negative 37 kDa/67 kDa laminin receptor mutant impairs PrP(Sc) propagation in scrapie-infected neuronal cells. J. Mol. Biol. 358 (2006) 57-66
30. C. Zuber, S. Knackmuss, G. Zemora, U. Reusch, E. Vlasova, D. Diehl, V. Mick, K. Hofmann, D. Nikles, T. Fröhlich, G. Arnold, B. Brenig, E. Wolf, H. Lahm, M. Little, S. Weiss, Invasion of tumorigenic HT1080 cells is impeded by downregulating or blocking the 37 kDa/67 kDa laminin receptor, J. Mol. Biol. (in press). doi:10.1016/j.jmb.2008.02.004.
31. Ito M., Shinagawa M., Doi S., Sasaki S., Isomura H., Takahashi K., Goto H., and Sato G. Effects of the antiserum against a fraction enriched in scrapie-associated fibrils on the scrapie incubation period in mice. Microbiol. Immunol. 32 (1988) 749-753
32. Rieger R., Edenhofer F., Lasmezas C.I., and Weiss S. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat. Med. 3 (1997) 1383-1388
33. Kaneda Y., Kinoshita K., Sato M., Tanaka K., and Kaneda Y. The analysis of 40 kDa nuclear protein, p40, in interphase cells and mitotic cells. J. Cell Sci. 106 Pt 3 (1993) 741-748.
34. Kinoshita K., Kaneda Y., Sato M., Saeki Y., Wataya-Kaneda M., and Hoffmann A. LBP-p40 binds DNA tightly through associations with histones H2A, H2B, and H4. Biochem. Biophys. Res. Commun. 253 (1998) 277-282
35. Sato M., Kinoshita K., Kaneda Y., Saeki Y., Iwamatsu A., and Tanaka K. Analysis of nuclear localization of laminin binding protein precursor p40 (LBP/p40). Biochem. Biophys. Res. Commun. 229 (1996) 896-901
36. Salama R.H., Muramatsu H., Zou K., Inui T., Kimura T., and Muramatsu T. Midkine binds to 37-kDa laminin binding protein precursor, leading to nuclear transport of the complex. Exp. Cell Res. 270 (2001) 13-20
37. Shibata Y., Muramatsu T., Hirai M., Inui T., Kimura T., Saito H., McCormick L.M., Bu G., and Kadomatsu K. Nuclear targeting by the growth factor midkine. Mol. Cell. Biol. 22 (2002) 6788-6796
38. Hundt C., Peyrin J.M., Haik S., Gauczynski S., Leucht C., Rieger R., Riley M.L., Deslys J.P., Dormont D., Lasmezas C.I., and Weiss S. Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor. EMBO J. 20 (2001) 5876-5886
39. Wan K.M., Nickerson J.A., Krockmalnic G., and Penman S. The nuclear matrix prepared by amine modification. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 933-938