Hippocampal dysfunction during free word association in male patients with schizophrenia

Schizophrenia Research

Volumn 101, Issue 1-3, 2008, Pages 242-255

  Kircher, Tilo ^a   Whitney, Carin ^a   Krings, Timo ^a   Huber, Walter ^b   Weis, Susanne ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

fMRI; Formal thought disorder; Hippocampus; Schizophrenia; Speech production; Word association

Indexed keywords

ADULT; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; HYPOTHESIS; MALE; PERSONALITY TEST; PHONETICS; PRIORITY JOURNAL; SCHIZOPHRENIA; SEMANTIC MEMORY; STIMULUS RESPONSE; THOUGHT DISORDER; VERBAL MEMORY;

ADOLESCENT; ADULT; BRAIN MAPPING; COGNITION DISORDERS; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PAIRED-ASSOCIATE LEARNING; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEMANTICS; VERBAL BEHAVIOR;

EID: 42749091893     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2008.02.003     Document Type: Article

References (68)

1. Achim A.M., and Lepage M. Episodic memory-related activation in schizophrenia: meta-analysis. Br. J. Psychiatry 187 (2005) 500-509
2. Andreasen N.C. The scale for the assessment of positive symptoms (SAPS) (1984), University of Iowa, Iowa City
3. Andreasen N.C. The scale for the assessment of negative symptoms (SANS) (1984), University of Iowa, Iowa City
4. Annett M. Classification of hand preference by association analysis. Br. J. Psychiatry 61 (1970) 303-321
5. Artiges E., Martinot J.L., Verdys M., Attar-Levy D., Mazoyer B., Tzourio N., et al. Altered hemispheric functional dominance during word generation in negative schizophrenia. Schizophr. Bull. 26 (2000) 709-721
6. Baayen R.H., Piepenbrock R., and van Rijn H. The CELEX Lexical Database (CD-ROM) (1993), University of Pennsylvania, Philadelphia, PA (Linguistic Data Consortium)
7. Bleuler E. Diagnostische Assoziationsstudien.Vorwort. Über die Bedeutung von Assoziationsversuchen. J. Psychol. Neurol. 3 (1904) 49-54
8. Bokat C.E., and Goldberg T.E. Letter and category fluency in schizophrenic patients: a meta-analysis. Schizophr. Res. 64 (2003) 73-78
9. Boksman K., Théberge J., Williamson P., Drost D.J., Malla A., Densmore M., et al. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr. Res. 75 (2005) 247-263
10. Bonner-Jackson A., Haut K., Csernansky J.G., and Barch D.M. The influence of encoding strategy on episodic memory and cortical activity in schizophrenia. Biol. Psychiatry 58 (2005) 47-55
11. Bookheimer S. Functional MRI of language: new approaches to understanding cortical organization of semantic processing. Annu. Rev. Neurosci. 25 (2002) 151-188
12. Braak E., Griffing K., Arai K., Bohl J., Bratzke H., and Braak H. Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?. Eur. Arch. Psychiatry Clin. Neurosci. 249 (1999) S14-S22
13. Cabeza R., and Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. J. Cogn. Neurosci. 12 (2000) 1-47
14. Curtis V.A., Bullmore E.T., Brammer M.J., Wright I.C., Williams S.C., Morris R.G., et al. Attenuated frontal activation during a verbal fluency task in patients with schizophrenia. Am. J. Psychiatry 155 (1996) 1056-1063
15. Davachi L., and Wagner A.D. Hippocampal contributions to episodic encoding: insights from relational and item based learning. J. Neurophysiol. 88 (2002) 982-990
16. Dye S.M., Spence S.A., Bench C.J., Hirsch S.R., Stefan M.D., Sharma T., et al. No evidence for left superior temporal dysfunction in asymptomatic schizophrenia and bipolar disorder. PET study of verbal fluency. Br. J. Psychiatry 175 (1999) 367-374
17. Eichenbaum H., Otto T., and Cohen N.J. Two functional components of the hippocampal memory system. Behav. Brain Sci. 17 (1994) 449-518
18. Fallgatter A.J., Bartsch A.J., Zielasek J., and Herrmann M.J. Brain electrical dysfunction of the anterior cingulate in schizophrenic patients. Psychiatry Res. 124 (2003) 37-48
19. Fernández G., Weis S., Stoffel-Wagner B., Tendolkar I., Reuber M., Beyenburg S., et al. Menstrual cycle-dependent neural plasticity in the adult human brain is hormone, task, and region specific. J. Neurosci. 23 (2003) 3790-3795
20. Fletcher P.C., Frith C.D., Grasby P.M., Friston K.J., and Dolan R.J. Local and distributed effects of apomorphine on fronto-temporal function in acute unmedicated schizophrenia. J. Neurosci. 16 21 (1996) 7055-7062
21. Friston K.J., Fletcher P., Josephs O., Holmes A., Rugg M.D., and Turner R. Event-related fMRI: characterizing differential responses. Neuroimage 7 (1998) 30-40
22. Frith C.D., Friston K.J., Herold S., Silbersweig D., Fletcher P., Cahill C., et al. Regional brain activity in chronic schizophrenic patients during performance of a verbal fluency task. Br. J. Psychiatry 167 (1995) 343-349
23. Fu C.H., Suckling J., Williams S.C., Andrew C.M., Vythelingum G.N., and McGuire P.K. Effects of psychotic state and task demand on prefrontal function in schizophrenia: an fMRI study of overt verbal fluency. Am. J. Psychiatry 162 (2005) 485-494
24. Gold J.J., Hopkins R.O., and Squire L.R. Single-item memory, associative memory, and the human hippocampus. Learn. Mem. 13 (2006) 644-649
25. Goldberg T.E., and Weinberger D.R. Thought disorder in schizophrenia: a reappraisal of older formulations and an overview of some recent studies. Cogn. Neuropsychiatry 5 (2000) 1-19
26. Goldman H.H., Skodol A.E., and Lave T.R. Revising Axis V for DSM-IV: a review of measures of social functioning. Am. J. Psychiatry 149 (1992) 1148-1156
27. Heckers S., and Titone D. Hippocampus, IV: relational memory. Am. J. Psychiatry 162 (2005) 663
28. Heckers S., Rauch S.L., Goff D., Savage C.R., Schacter D.L., Fischman A.J., et al. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat. Neurosci. 1 (1998) 318-323
29. Henke K., Mondadori C.R.A., Treyer V., Nitsch R.M., Buck A., and Hock C. Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe. Neuropsychologia 41 (2003) 863-876
30. Highley J.R., Esiri M.M., McDonald B., Cooper S.J., and Crow T.J. Temporal-lobe length is reduced, and gyral folding is increased in schizophrenia: a post-mortem study. Schizophr. Res. 34 (1998) 1-12
31. Indefrey P., and Levelt W.J.M. The spatial and temporal signatures of word production components. Cognition 92 (2004) 101-144
32. Jessen F., Scheef L., Germeshausen L., Tawo Y., Kockler M., Kuhn K.-U., et al. Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients. Am. J. Psychiatry 160 (2003) 1305-1312
33. Kerns J.G., and Berenbaum H. Cognitive impairments associated with formal thought disorder in people with schizophrenia. J. Abnorm. Psychology 111 (2002) 211-234
34. Kircher T.T.J., Bulimore E.T., Brammer M.J., Williams S.C.R., Broome M.R., Murray R.M., et al. Differential activation of the temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder. Schizophr. Res. 50 (2001) 27-40
35. Kircher T.T.J., Liddle P.F., Brammer M.J., Williams S.C.R., Murray R.M., and McGuire P.K. Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia. Psychol. Med. 32 (2002) 439-449
36. Kraepelin E. Experimentelle Studien über Assoziationen. Auth. Ber. 56. Vers (1889), Deutsch Naturf. u. Ärzte. Freiburg, 1889
37. Kuperberg G.R., Deckersbach T., Holt D., Goff D., and West W.C. Increased temporal and prefrontal activity to semantic associations in schizophrenia. Arch. Gen. Psychiatry 64 (2007) 138-151
38. Lehrl S., Triebig G., and Fischer B. Multiple-choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurol. Scand. 91 (1995) 335-345
39. Mayes A.R., Holdstock J.S., Isaac C.L., Montaldi D., Grigor J., Gummer A., et al. Associative recognition in a patient with selective hippocampal lesions and relatively normal item recognition. Hippocampus 14 (2004) 763-784
40. McGuire P.K., Quested D.J., Spence S.A., Murray R.M., Frith C.D., and Liddle P.F. Pathophysiology of 'positive' thought disorder in schizophrenia. Br. J. Psychiatry 173 (1998) 231-235
41. Mitchell R.L.C., and Crow T.J. Right hemisphere language functions and schizophrenia: the forgotten hemisphere?. Brain 128 (2005) 963-978
42. Nelson M.D., Saykin A.J., Flashman L.A., and Riordan H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging. Arch. Gen. Psychiatry 55 (1998) 433-440
43. Ngan E.T.C., Vouloumanos A., Cairo T.A., Laurens K.R., Bates A.T., Anderson C.M., et al. Abnormal processing of speech during oddball target detection in schizophrenia. Neuroimage 20 (2003) 889-897
44. Ohnishi T., Hashimoto R., Mori T., Nemoto K., Moriguchi Y., Iida H., et al. The association between the Val158Met polymorphism of the catechol-0-methyltransferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain 129 (2006) 399-410
45. Pihlajamäki M., Tanila H., Hänninen T., Könönen M., Laakso M., Partanen K., et al. Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study. Ann. Neurol. 47 (2000) 470-476
46. Prince S.E., Daselaar S.M., and Cabeza R. Neural correlates of relational memory: Successful encoding and retrieval of semantic and perceptual associations. J. Neurosci. 25 (2005) 1203-1210
47. Reske, M., Kellermann, T., Habel, U., Jon Shah, N., Backes, V., von Wilmsdorff, M., et al., 2007. Stability of emotional dysfunctions? A long-term fMRI study in first-episode schizophrenia. J. Psychiatr. Res. 41, 918-927.
48. Rossi A., Serio A., Stratta P., Petruzzi C., Schiazza G., Mancini F., et al. Planum temporale asymmetry and thought disorder in schizophrenia. Schizophr. Res. 12 (1984) 1-7
49. Shaywitz B.A., Shaywitz S.E., Pugh K.R., Constable R.T., Skudiarski P., Fulbright R.K., et al. Sex differences in the functional organization of the brain for language. Nature 373 (1995) 607-609
50. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N. Engl. J. Med. 327 (1992) 604-612
51. Shenton M.E., Dickey C.C., Frumin M., and McCarley R.W. A review of MRI findings in schizophrenia. Schizophr. Res. 15 (2001) 1-52
52. Simons J.S., and Spiers H.J. Prefrontal and medial temporal lobe interactions in long-term memory. Nat. Rev., Neurosci. 4 (2003) 637-648
53. Sitnikova T., Salisbury D.F., Kuperberg G., and Holcomb P.I. Electrophysiological insights into language processing in schizophrenia. Psychophysiology 39 (2002) 851-860
54. Slotnick S.D., Moo L.R., Segal J.B., and Hart Jr. J. Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes. Brain Res. Cogn. Brain Res. 17 (2003) 75-82
55. Snitz B.E., MacDonald III A., Cohen J.D., Cho R.Y., Becker T., and Carter C.S. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. Am. J. Psychiatry 162 (2005) 2322-2329
56. Sommer I.E., Aleman A., Bouma A., and Kahn R.S. Do women really have more bilateral language representation than men? A meta-analysis of functional imaging studies. Brain 127 (2004) 1845-1852
57. Spence S.A., Liddle P.F., Stefan M.D., Hellewell J.S.E., Sharma T., Friston K.J., et al. Functional anatomy of verbal fluency in people with schizophrenia and those at risk. Br. J. Psychiatry 176 (2000) 52-60
58. Spencer M.D., Moorhead T.W.J., McIntosh A.M., Stanfield A.C., Muir W.J., Hoare P., et al. Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study. Neuroimage 35 (2007) 1181-1191
59. Spiers H.J., Maguire E.A., and Burgess N. Hippocampal amnesia. Neurocase, 7 (2001) 357-382
60. Spitzer M., Braun U., Hermle L., and Maier S. Associative semantic network dysfunction in thought-disordered schizophrenic patients: direct evidence from indirect semantic priming. Biol. Psychiatry 34 (1993) 864-877
61. Talairach J., and Tournoux P. Co-planar stereotaxic atlas of the human brain (1988), Thieme, New York
62. Vandenberghe R., Price C., Wise R., Josephs O., and Frackowiak R.S.J. Functional anatomy of a common semantic system for words and pictures. Nature 383 (1996) 254-256
63. Vikingstad E.M., George K.P., Johnson A.F., and Cao Y. Cortical language lateralization in right handed normal subjects using functional magnetic resonance imaging. J. Neurol. Sci. 175 (2000) 17-27
64. Weiss A.P., Schacter D.L., Goff D.C., Rauch S.L., Alpert N.M., Fischman A.J., et al. Impaired hippocampal recruitment during normal modulation of memory performance in schizophrenia. Biol. Psychiatry 53 (2003) 48-55
65. Weiss E.M., Hofer A., Golaszewski S., Siedentopf C., Brinkhoff C., Kremser C., et al. Brain activation patterns during a verbal fluency test - a functional MRI study in healthy volunteers and patients with schizophrenia. Schizophr. Res. 70 (2004) 287-291
66. Whatmough C., and Chertkow H. rCBF to the hippocampal complex covaries with superior semantic memory retrieval. Behav. Brain Res. 181 (2007) 262-269
67. Yucel M., Brewer W.J., Harrison B.J., Fornito A., O'Keefe G.J., Olver J., et al. Anterior cingulate activation in antipsychotic-naive first-episode schizophrenia. Acta Psychiatr. Scand. 115 (2007) 155-158
68. Yurgelun-Todd D.A., Waternaux C.M., Cohen B.M., Gruber S.A., English C.D., and Renshaw P.F. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am. J. Psychiatry 153 (1996) 200-205