Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles

Virology

Volumn 375, Issue 1, 2008, Pages 118-129

  Clementz, Mark A ^a   Kanjanahaluethai, Amornrat ^b   O'Brien, Timothy E ^c   Baker, Susan C ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b Faculty of Medicine Chiang Mai University   (Thailand)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Coronavirus; Double membrane vesicles; Nonstructural proteins; ts mutant

Indexed keywords

ALANINE; ASPARAGINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CORONAVIRUS; GLYCOSYLATION; HUMAN; HUMAN CELL; MEMBRANE VESICLE; MITOCHONDRION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; TEMPERATURE; TEMPERATURE SENSITIVITY; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELL MEMBRANE; CRICETINAE; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MURINE HEPATITIS VIRUS; MUTAGENESIS, SITE-DIRECTED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS ASSEMBLY;

CORONAVIRUS; DASHEEN MOSAIC VIRUS; MURINE HEPATITIS VIRUS; RNA VIRUSES;

EID: 42749085841     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.01.018     Document Type: Article

References (43)

1. Baker S.C., Shieh C.K., Soe L.H., Chang M.F., Vannier D.M., and Lai M.M. Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein. J. Virol. 63 9 (1989) 3693-3699
2. Baker S.C., and Denison M.R. Cell biology of nidovirus replication complexes. In: Perlman S., Gallagher T., and Snijder E. (Eds). Nidoviruses (2008), ASM Press, Washington 103-113
3. Baric R.S., Fu K., Schaad M.C., and Stohlman S.A. Establishing a genetic recombination map for murine coronavirus strain A59 complementation groups. Virology 177 2 (1990) 646-656
4. Bonilla P.J., Hughes S.A., and Weiss S.R. Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59. J. Virol. 71 2 (1997) 900-909
5. Bost A.G., Carnahan R.H., Lu X.T., and Denison M.R. Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. J. Virol. 74 7 (2000) 3379-3387
6. Deming D.J., Graham R.L., Denison M.R., and Baric R.S. Processing of open reading frame 1a replicase proteins nsp7 to nsp10 in murine hepatitis virus strain A59 replication. J. Virol. 81 19 (2007) 10280-10291
7. Denison M.R., Hughes S.A., and Weiss S.R. Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology 207 1 (1995) 316-320
8. Donaldson E.F., Graham R.L., Sims A.C., Denison M.R., and Baric R.S. Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing. J. Virol. 81 13 (2007) 7086-7098
9. Fu K., and Baric R.S. Map locations of mouse hepatitis virus temperature-sensitive mutants: confirmation of variable rates of recombination. J. Virol. 68 11 (1994) 7458-7466
10. Fuerst T.R., Niles E.G., Studier F.W., and Moss B. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 83 21 (1986) 8122-8126
11. Goldsmith C.S., Tatti K.M., Ksiazek T.G., Rollin P.E., Comer J.A., Lee W.W., Rota P.A., Bankamp B., Bellini W.J., and Zaki S.R. Ultrastructural characterization of SARS coronavirus. Emerg. Infect. Dis. 10 2 (2004) 320-326
12. Gosert R., Kanjanahaluethai A., Egger D., Bienz K., and Baker S.C. RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J. Virol. 76 8 (2002) 3697-3708
13. Graham R.L., and Denison M.R. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. J. Virol. 80 23 (2006) 11610-11620
14. Harcourt B.H., Jukneliene D., Kanjanahaluethai A., Bechill J., Severson K.M., Smith C.M., Rota P.A., and Baker S.C. Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity. J. Virol. 78 24 (2004) 13600-13612
15. Kanjanahaluethai A., and Baker S.C. Identification of mouse hepatitis virus papain-like proteinase 2 activity. J. Virol. 74 17 (2000) 7911-7921
16. Kanjanahaluethai A., and Baker S.C. Processing of the replicase of murine coronavirus: papain-like proteinase 2 (PLP2) acts to generate p150 and p44. Adv. Exp. Med. Biol. 494 (2001) 267-273
17. Kanjanahaluethai A., Jukneliene D., and Baker S.C. Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2. J. Virol. 77 13 (2003) 7376-7382
18. Kanjanahaluethai A., Chen Z., Jukneliene D., and Baker S.C. Membrane topology of murine coronavirus replicase nonstructural protein 3. Virology 361 2 (2007) 391-401
19. Kopek B.G., Perkins G., Miller D.J., Ellisman M.H., and Ahlquist P. Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle. PLoS Biol. 5 9 (2007) e220
20. Lu Y., Lu X., and Denison M.R. Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. J. Virol. 69 6 (1995) 3554-3559
21. Lu X.T., Sims A.C., and Denison M.R. Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J. Virol. 72 3 (1998) 2265-2271
22. Masters P.S. The molecular biology of coronaviruses. Adv. Virus Res. 66 (2006) 193-292
23. Miller D.J., and Ahlquist P. Flock house virus RNA polymerase is a transmembrane protein with amino-terminal sequences sufficient for mitochondrial localization and membrane insertion. J. Virol. 76 19 (2002) 9856-9867
24. Miller D.J., Schwartz M.D., and Ahlquist P. Flock house virus RNA replicates on outer mitochondrial membranes in Drosophila cells. J. Virol. 75 23 (2001) 11664-11676
25. Miller D.J., Schwartz M.D., Dye B.T., and Ahlquist P. Engineered retargeting of viral RNA replication complexes to an alternative intracellular membrane. J. Virol. 77 22 (2003) 12193-12202
26. Oostra M., Te Lintelo E.G., Deijs M., Verheije M.H., Rottier P.J., and de Haan C.A. Localization and membrane topology of the coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication. J. Virol. 81 22 (2007) 12323-12336
27. Peiris J.S., Guan Y., and Yuen K.Y. Severe acute respiratory syndrome. Nat. Med. 10 12 Suppl (2004) S88-S97
28. Prentice E., Jerome W.G., Yoshimori T., Mizushima N., and Denison M.R. Coronavirus replication complex formation utilizes components of cellular autophagy. J. Biol. Chem. 279 11 (2004) 10136-10141
29. Ratkowsky D. "Handbook of Nonlinear Regression Models." (1990), Marcel Dekker, New York
30. Salonen A., Ahola T., and Kaariainen L. Viral RNA replication in association with cellular membranes. Curr. Top. Microbiol. Immunol. 285 (2005) 139-173
31. Sawicki S.G., Sawicki D.L., Younker D., Meyer Y., Thiel V., Stokes H., and Siddell S.G. Functional and genetic analysis of coronavirus replicase-transcriptase proteins. PLoS Pathog. 1 4 (2005) e39
32. Sawicki S.G., Sawicki D.L., and Siddell S.G. A contemporary view of coronavirus transcription. J. Virol. 81 1 (2007) 20-29
33. Schaad M.C., Stohlman S.A., Egbert J., Lum K., Fu K., Wei Jr. T., and Baric R.S. Genetics of mouse hepatitis virus transcription: identification of cistrons which may function in positive and negative strand RNA synthesis. Virology 177 2 (1990) 634-645
34. Schiller J.J., Kanjanahaluethai A., and Baker S.C. Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a. Virology 242 2 (1998) 288-302
35. Shi S.T., Schiller J.J., Kanjanahaluethai A., Baker S.C., Oh J.W., and Lai M.M. Colocalization and membrane association of murine hepatitis virus gene 1 products and de novo-synthesized viral RNA in infected cells. J. Virol. 73 7 (1999) 5957-5969
36. Siddell S., Sawicki D., Meyer Y., Thiel V., and Sawicki S. Identification of the mutations responsible for the phenotype of three MHV RNA-negative ts mutants. Adv. Exp. Med. Biol. 494 (2001) 453-458
37. Snijder E.J., van der Meer Y., Zevenhoven-Dobbe J., Onderwater J.J., van der Meulen J., Koerten H.K., and Mommaas A.M. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J. Virol. 80 12 (2006) 5927-5940
38. Sparks J.S., Lu X., and Denison M.R. Genetic analysis of murine hepatitis virus nsp4 in virus replication. J. Virol. 81 22 (2007) 12554-12563
39. Stadler K., Masignani V., Eickmann M., Becker S., Abrignani S., Klenk H.D., and Rappuoli R. SARS-beginning to understand a new virus. Nat. Rev. Microbiol. 1 3 (2003) 209-218
40. Younker D.R., and Sawicki S.G. Negative strand RNA synthesis by temperature-sensitive mutants of mouse hepatitis virus. Adv. Exp. Med. Biol. 440 (1998) 221-226
41. Yount B., Denison M.R., Weiss S.R., and Baric R.S. Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. J. Virol. 76 21 (2002) 11065-11078
42. Ziebuhr J., and Snijder E.J. The coronavirus replicase gene: special enzymes for special viruses. In: Thiel V. (Ed). "Coronaviruses: Molecular and Cellular Biology" (2007), Caister Academic Press
43. Ziebuhr J., Snijder E.J., and Gorbalenya A.E. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J. Gen. Virol. 81 Pt 4 (2000) 853-879