Role of desmoplasia in recurrence of stage II colorectal cancer within five years after surgery and therapeutic implication

Cancer Investigation

Volumn 26, Issue 4, 2008, Pages 419-425

  Crispino, Pietro ^a   De Toma, Giorgio ^b   Ciardi, Antonio ^a   Bella, Antonino ^c   Rivera, Margherita ^a   Cavallaro, Giuseppe ^b   Polistena, Andrea ^b   Fornari, Francesca ^b   Unim, Hans ^a   Pica, Roberta ^a   Cassieri, Claudio ^a   Mingazzini, Pietro Luigi ^a   Paoluzi, Paolo ^a,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d POLICLINICO UMBERTO I   (Italy)

Author keywords

Colorectal cancer; Desmoplasia; Disease recurrence; Mortality

Indexed keywords

ANTINEOPLASTIC AGENT;

ADENOMA; ADULT; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CLASSIFICATION; CANCER MORTALITY; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER TISSUE; CLINICAL ARTICLE; COLON RESECTION; COLORECTAL CANCER; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; LYMPHOCYTIC INFILTRATION; MALE; PRIORITY JOURNAL; PROGNOSIS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE; STROMA; SURVIVAL RATE; TREATMENT OUTCOME; VEIN;

ADENOCARCINOMA; AGED; ANTINEOPLASTIC AGENTS; CHEMOTHERAPY, ADJUVANT; COLECTOMY; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FOLLOW-UP STUDIES; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; NEOPLASM CIRCULATING CELLS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM STAGING; RISK; STAINING AND LABELING; STROMAL CELLS; SURVIVAL ANALYSIS; SURVIVAL RATE; VEINS;

EID: 42649139216     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900701788155     Document Type: Article

References (29)

1. Kinzler, K.W.; Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 1996, 87, 159-170.
2. Compton, CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003, 16, 376-388.
3. Hewitt, R.E.; Powe, D.G.; Carter, I.; et al. Desmoplasia and its relevance to colorectal tumour invasion. Int J Cancer 1993, 52, 62-9.
4. Lunevicius, R.; Nakamishi, H.; Ito, S.; et al. Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. J Cancer Res Clin Oncol 2001, 127, 193-9.
5. Caporale, A.; Vestri, A.R.; Benvenuto, E.; et al. Is Desmoplasia a protective factor for survival in patients with colorectal carcinoma. Clin Gastroent and Hepatol 2005, 3, 370-5.
6. Jass, J.R.; Atkin, W.S.; Cuzick, J.; et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathol 1986, 10, 437-459.
7. Liotta, L.A.; Rao, C.N.; Barsky, J.N. Tumour invasion of extracellular matrix. Lab Invest 1983, 49, 636-49.
8. Nakada, I.; Tasaki, T.; Ubukata, H.; et al. Desmoplastic response in biopsy specimens of early carcinoma is predictive of deep submucosal invasion. Dis Colon Rectum 1988, 41, 896-900.
9. Nishimura, R.; Hesebe, T.; Tsubno, J.; et al. The fibrotic focus in advanced colorectal carcinoma: a hitherto unrecognized historical predictor for liver metastasis. Virchows Arch 1998, 433, 517-22.
10. Gabbert, H.; Wagner, R.; Moll, R.; et al. Tumour dedifferentiation: an important step in tumour invasion. Int J Cancer 1993, 52, 62-9.
11. Ueno, H.; Jones, A.M.; Wilkinson K.A.; et al. Histological categorisation of fibrotic cancer stroma in advanced rectal cancer. Gut 2004, 53, 581-6.
12. Martin, M.; Pujuguet, P.; Martin, F. Role of stromal myofibroblast infiltrating colon cancer in tumour invasion. Pathol Res Pract 1996, 192, 712-7.
13. Hauptmann, S.; Budianto, D.; Denkert, C.; et al. Adhesion and migration of HRT-18 colorectal carcinoma cells on extracellular matrix components typical for the desmoplastic stroma of colorectal adenocarcinomas. Oncol 2003, 65, 174-81.
14. Lieubeau, B.; Heynam, M.F.; Henry, F.; et al. Immunomodulatory effect of tumour-associated fibroblast in colorectal-tumour development. Int J Cancer 1999, 81, 629-36.
15. Kapiteijn, E.; Corrie M.; Nagtegaal, I.D.; et al. Preoperative Radiotherapy Combined with Total Mesorectal Excision for resectable rectal Cancer. N Engl J Med 2001, 345, 638-646.
16. Krook, J.E.; Moertel, C.G.; Gunderson, L.L.; et al. Effective surgical adjuvant therapy for high risk rectal carcinoma. N Engl JMed 1991, 324, 709-715.
17. Marsh, P.J.; James, R.D.; Schofield, P.F.; et al. Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma. Results of a prospective randomized trial. Dis Colon Rectum 1994, 37, 1205-1214.
18. Medical Research Council Rectal CancerWorking Party. Randomized trial of surgery alone versus radiotherapy followed by surgery for mobile cancer of the rectum. Lancet 1996, 348, 1610-1614.
19. Medical Research Council Rectal CancerWorking Party. Randomized trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet 1996, 348, 1605-1610.
20. Sobin, L.H.; Wittekind CH (editors). TNM classification of malignant tumours. Sixth Edition, Philadelphia: JB Lippincott, 2002.
21. Ueno, H.; Jones, A.; Jass, J.R.; et al. Clinicopathological significance of the "keloid like" collagen and myxoid stroma in advanced rectal cancer. Histopathol 2002, 40, 327-34.
22. Prall, F.; Nizze, H.; Barten M. Tumour budding as prognostic factor in stage I/II colorectal carcinoma. Histopathol 2005, 47, 17-24.
23. Mescoli, C.; Rugge, M.; Pucciarelli, S.; et al. High prevalence of isolated tumour cells tumour cells in regional lymph nodes from pN0 colorectal cancer. J Clin Pathol 2006, 59, 870-4.
24. Eisenberg, B.; Decosse, J.J.; Harford, F.; et al. Carcinoma of the colon and rectum: the natural history reviewed in 1704 patients. Cancer 1982, 49, 1131-4.
25. Shurlch, W.; Seenarer, T.A.; Gabbiani, G. In Sternberg S (Ed) Histology for pathologist, 2nd ed Philadelphia. Lippincott-Raven Publishers 1997, 129-65.
26. Heinen, E.; Corwann, N.; Kinet-Denoel C. The Limph-follicle: a hard nut to crack. Immunol Today 1988, 9, 240-3.
27. Unaue, E.R.; Allen, P.M. The basis of the immunoregulatory role of macrophages and of the accessory cells. Science 1987, 236, 551-7.
28. Sandel, M.H.; Dadabayev, A.R.; Menon, A.G.; et al. Prognostic value of Tumor-infiltrating dendritic celles in Colorectal Cancer: Role of maturation status and intratumoral localisation. Clin Cancer Res 2005, 11, 2576-82.
29. Chau, I.; Cunnigham, D. Adjuvant therapy in colorectal cancer: current status and future directions. Cancer Treat Rev 2002, 28, 223-36.