Apoptotic cell death and p53 expression in leiomyosarcoma of soft-tissue origin

Yonago Acta Medica

Volumn 44, Issue 2, 2001, Pages 115-123

  Yoshida, Haruhiko ^a   Watanabe, Mari ^a   Shomori, Kohei ^a   Ito, Hisao ^a   Minamizaki, Takeshi ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Immunohistochemistry; Leiomyosarcoma; p53 protein

Indexed keywords

EID: 42649115701     PISSN: 05135710     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Aihara M, Truong LD, Dunn JK, Wheeler TM, Scardino PT, Thompson TC. Frequency of apoptotic bodies positively correlates with Gleason grade in prostatic Cancer. Hum Pathol 1994; 25:797-801.
2. Arai T, Kino I. Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas. J Pathol 1995;176:37-44.
3. Enzinger FM, Weiss SW. Soft tissue tumors. 2nd ed. St Lous: CV Mosby, 1988. Chapter 15. Leiomyosarcoma; p. 402-421.
4. Chen J, Wu X, Lin J, Levine AJ. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996; 16:2445-2452.
5. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993;362:849-852.
6. Endo K, Sakatani T, Watanabe M, Yoshida H, Nannba E, Ito H. Wild-type p53 transfer resulted in cell cycle arrest, but not apoptosis of newly established human malignant fibrous histiocytoma cell line. Internat J Oncol 1999;15:935-942.
7. Drobijak M, Latres E, Pollack D, Karpeh M, Dudas M, Woodruff JM, et al. Prognositic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. J Natl Cancer Inst 1994;86:549-554.
8. Hashimoto H, Daimaru Y, Tsuneyoshi M, Enjoji M. Leiomyosarcoma of the external soft tissues. Cancer 1986;57:2077-2088.
9. Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J 1996;15:1596-1606.
10. Gagvrielli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
11. Ikeda M, Shomori K, Endo K, Makino T, Matsuura T, Ito H. Frequent occurrence of apoptosis is an early event in the oncogenesis of human gastric carcinoma. Virchows Arch 1998;432:43-47.
12. Kawauchi S, Fukuda T, Oda Y, Saito T, Takeshita M, Yokoyama K, et al. Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod pathol 2000;13: 755-765.
13. Kasagi N, Oomyo Y, Shirai H, Tsujitani S, Ito H. Apoptotic cell death in human gastric carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Jpn J Cancer Res 1994;85:939-945.
14. Konomoto T, Fukuda T, Hayashi K, Kumazawa J, Tsuneyoshi M. Leiomyosarcoma in soft tissue: examination of p53 status and cell proliferating factors in different locations. Hum Pathol 1998; 29:74-81.
15. Kerr JFK, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
16. Kerr JFR, Winterford CM, Hormon BV. Apoptosis: its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026.
17. Leoncini L, Del Vacchio MT, Megha T, Barbini P, Galieni P, Piled S, et al. Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas. Am J Pathol 1993; 142:755-763.
18. Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci USA 1994;91:2026-2030.
19. Nakanishi H, Ohsawa M, Naka N, Uchida, Ochi T, Aozasa K. Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis. Oncology 1997;54:238-244.
20. Stefanou DG, Nonni AV, Agnantis NJ, Athnassiadou SE, Briassoulis E, Pavlidis N. p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different types of human sarcomas: a ten-year follow-up study. Anticancer Res 1998;18:4673-4681.
21. O'Reilly PE, Raab SS, Niemann TH, Rodgers JR, Robinson RA. p53, proliferating cell nuclear antigen, and Ki-67 expression in extrauterine leiomyosarcoma. Mod Pathol 1997;10:91-97.
22. Staunton MJ, Gaffney EF. Tumor type is a determinant of susceptability to apoptosis. Am J Clin Pathol 1995;103:300-307.
23. Tatebe S, Ishida M, Kasagi N, Tsujitani S, Kaibara N, Ito H. Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling, Int J Cancer 1996;65: 173-177.
24. Toffoli G, Doglioni C, Cernigoi C, Frustaci S, Perin T, Canal B, et al: p53 over-expression in human soft tissue sarcomas: relation to biological aggressiveness. Ann Oncol 1994;5:167-172.
25. Umansky SR. The genetic program of cell death. Hypothesis and some applications: transformation, carcinogenesis, aging. J Theor Biol 1982; 97:591-602.
26. Valenti MT, Azzarello G, Vinate O, Manconi R, Balducci E, Guidolin D, et al. Differentiation, proliferation and apoptosis levels in human leiomyoma and leiomyosarcoma. J Cancer Res Clin Oncol 1998;124:93-10
27. Wyllie AH. Cell death: a new classification separating apoptosis from necrosis. In: Bowen ID, Lockshin RA, eds. Cell death in biology and pathology. London: Chapman and Hall; 1981. p. 9-34.
28. Yoo J, Lee HK, Kang CS, Park WS, Lee JY, Shim SI. p53 gene mutation and p53 protein expression in human soft tissue sarcomas. Arch Pathol Lab Med 1997;121:395-399.
29. Yuki M, Yokota K, Okuyama S. Cell proliferation and cell death (apoptosis) as indices differentiating malignant from benign gastrointestinal myogenic tumors. Nippon Shokakibyo Gakkai Zasshi 1995;92:206-216 (in Japanese with English abstract).