Improving the effectiveness of interventions in palliative care: The potential role of qualitative research in enhancing evidence from randomized controlled trials

Palliative Medicine

Volumn 22, Issue 2, 2008, Pages 123-131

  Flemming, Kate ^a   Adamson, Joy ^a   Atkin, Karl ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Evidence based practice; Palliative care; Qualitative research; Randomized controlled trials; Research design

Indexed keywords

HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADVANCED CANCER; AROMATHERAPY; ARTICLE; BREAST CANCER; CANCER PALLIATIVE THERAPY; CAREGIVER SUPPORT; CLINICAL RESEARCH; CLINICAL TRIAL; COCHRANE LIBRARY; CONCEPTUAL FRAMEWORK; DRUG EFFICACY; EVIDENCE BASED PRACTICE; FUNDING; HEALTH SERVICES RESEARCH; HORMONE SUBSTITUTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFORMATION DISSEMINATION; INFORMATION RETRIEVAL; MASSAGE; PALLIATIVE THERAPY; PATIENT PARTICIPATION; PROSTATE CANCER; PUBLISHING; QUALITATIVE RESEARCH; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; RANDOMIZATION; RESEARCH ETHICS; THERAPY EFFECT; THROMBOSIS;

HUMANS; PALLIATIVE CARE; PATIENT SELECTION; QUALITATIVE RESEARCH; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN;

EID: 42649114813     PISSN: 02692163     EISSN: None     Source Type: Journal    
DOI: 10.1177/0269216307087319     Document Type: Article

References (59)

1. Strauss, SE, Scott Richardson, W, Glasziou, P. Evidence-Based Medicine: How to practice and teach EBM, thirrd edition. Edinburgh: Elsevier Churchill Livingstone, 2005.
2. Piggott, M, McGee, H, Feuer, D. Has CONSORT improved the reporting of randomized controlled trials in the palliative care literature? A systematic review. Palliat Med 2004; 18: 32-38.
3. McWhinney, IR, Bass, MJ, Donner, A. Evaluation of a palliative care service: problems and pitfalls. BMJ 1994; 309: 1340-1342.
4. Rinck, GC, van den Bos, GA, Kleijnen, J, de Haes, HJ, Schade, E, Veenhof, CH. Methodologic issues in effectiveness research on palliative cancer care: a systematic review. J Clin Oncol 1997; 15: 1697-1707.
5. Medical Research Council. A Framework for Development and Evaluation of RCTs for Complex Interventions to Improve Health. London: MRC, 2001.
6. Medical Research Council. Clinical Trials for Tomorrow: An MRC Review of Randomised Controlled Trials. London: MRC. Clinical Trial Series, 2003,
7. Hussain-Gambles, M, Atkin, K, Leese, B. South Asian participation in clinical trials: the views of lay people and health professionals. Health Policy 2006; 77: 149-165.
8. Atkin, K, Ahmad, WI. Living a 'normal' life: young people coping with thalassaemia major or sickle cell disorder. Soc Sci Med 2001; 53: 615-626.
9. Atkin, K, Chattoo, S. Approaches to conducting qualitative research in ethnically diverse populations. In: Nazroo, J, (ed). Methodological Issues in Research Relating to Black and Minority Ethnic Groups: Publishing the Evidence. London: Taylor Francis, 2006,
10. Bowling, A, Ebrahim, S, (eds). Handbook of Health Research Methods. Maidenhead: Open University Press, 2005.
11. Adamson, J. Combined qualitative and quantitative designs. In: Bowling, A, Ebrahim, S, (eds). Handbook of Health Research Methods. Maidenhead: Open University Press, 2005.
12. Hammersley, M. Deconstructing the qualitative-quantitative divide. In: Brannen, J, (ed). Mixing Methods: Qualitative and Quantitative Research. Aldershot: Ashgate Publishing Company, 1992.
13. Brannen, J. Combining qualitative and quantitative approaches: an overview. In: Brannen, J, (ed). Mixing Methods: Qualitative and Quantitative Research. Aldershot: Ashgate Publishing Company, 1992.
14. Flemming, K. The knowledge base for evidence-based nursing: a role for mixed methods research? ANS Adv Nurs Sci 2007; 30: 41-51.
15. Greene, JC, Caracelli, VJ, Graham, WF, Toward a conceptual framework for mixed-method evaluation designs. Educ Eval Policy Anal 1989; 11: 255-274.
16. Teddlie, C, Tashakkori, A. Major issues and controversies in the use of mixed methods in the social and behavioural sciences. In: Teddlie, C, Tashakkori, A, (eds). Handbook of Mixed Methods in Social and Behavioural Research. Thousand Oaks, CA: Sage, 2003,
17. Bryman, A. Social Research Methods, second edition. Oxford: Oxford University Press, 2004.
18. Mount, BM, Cohen, R, MacDonald, N, Bruera, E, Dudgeon, DJ. Ethical issues in palliative care research revisited. Palliat Med 1995; 9: 165-166.
19. Robbins, M. Evaluating Palliative Care. Establishing the Evidence Base. Oxford: Oxford University Press, 1998.
20. de Raeve, L. Ethical issues in palliative care research. Palliat Med 1994; 8: 298-305.
21. Pink, T. Moral obligation. In: O'Hear, A, (ed). Modern Moral Philosophy. Cambridge: Cambridge University Press, 2004.
22. Weber, M. Essays in Sociology. London: Kegan Paul, 1948.
23. Janssens, R, Gordijn, B. Clinical trials in palliative care: an ethical evaluation. Patient Educ Couns 2000; 41: 55-62.
24. Ling, J, Rees, E, Hardy, J. What influences participation in clinical trials in palliative care in a cancer centre? Eur J Cancer 2000; 36: 621-626.
25. Jubb, AM. Palliative care research: trading ethics for an evidence base. J Med Ethics 2002; 28: 342-346.
26. Casarett, DJ, Karlawish, JH. Are special ethical guidelines needed for palliative care research? J Pain Symptom Manage 2000; 20: 130-139.
27. Addington-Hall, J. Research sensitivities to palliative care patients. Eur J Cancer Care (Engl) 2002; 11: 220-224.
28. Grande, GE, Todd, CJ. Why are trials in palliative care so difficult? Palliat Med 2000; 14: 69-74.
29. Gelber, RD, Goldhirsch, A. Can a clinical trial be the treatment of choice for patients with cancer? J Natl Cancer Inst 1988; 80: 886-887.
30. Fagge, D, Corrie, P, Regan, J. Consumers and trials. Lancet 2001; 358: 763-764.
31. Small, N, Rhodes, P. Too Ill to Talk? User Involvement in Palliative Care. London: Routledge, 2000.
32. Marsden, J, Bradburn, J. Patient and clinician collaboration in the design of a national randomized breast cancer trial. Health Expect 2004; 7: 6-17.
33. Thornton, H. Patient perspectives on involvement in cancer research in the UK. Eur J Cancer Care (Engl) 2002; 11: 205-209.
34. Donovan, J, Mills, N, Smith, M, Brindle, L, Jacoby, A, Peters, T, et al. Quality improvement report: Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. Commentary: presenting unbiased information to patients can be difficult. BMJ 2002; 325: 766-770.
35. Thornton, H, Dixon-Woods, M. Recruitment of women into trials. Lancet 2002; 359: 164-165.
36. Aranda, S. Changing paradigms in research: do we need to rethink the future? Prog Palliat Care 2000; 8: 193-197.
37. Kendall, M, Harris, F, Boyd, K, Sheikh, A, Murray, SA, Brown, D, et al. Key challenges and ways forward in researching the "good death": qualitative in-depth interview and focus group study. BMJ 2007; 334: 521.
38. Ewing, G, Rogers, M, Barclay, S, McCabe, J, Martin, A, Todd, C. Recruiting patients into a primary care based study of palliative care: why is it so difficult? Palliat Med 2004; 18: 452-459.
39. Cook, AM, Finlay, IG, Butler-Keating, RJ. Recruiting into palliative care trials: lessons learnt from a feasibility study. Palliat Med 2002; 16: 163-165.
40. Hudson, P. The experience of research participation for family caregivers of palliative care cancer patients. Int J Palliat Nurs 2003; 9: 120-123.
41. Grunfeld, E, Zitzelsberger, L, Coristine, M, Aspelund, F. Barriers and facilitators to enrollment in cancer clinical trials: qualitative study of the perspectives of clinical research associates. Cancer 2002; 95: 1577-1583.
42. Westcombe, AM, Gambles, MA, Wilkinson, SM, Barnes, K, Fellowes, D, Maher, EJ, et al. Learning the hard way! Setting up an RCT of aromatherapy massage for patients with advanced cancer. Palliat Med 2003; 17: 300-307.
43. Cox, K. Enhancing cancer clinical trial management: recommendations from a qualitative study of trial participants' experiences. Psychooncology 2000; 9: 314-322.
44. Raudonis, BM. Ethical considerations in qualitative research with hospice patients. Qual Health Res 1992; 2: 238-249.
45. Barnett, M. Interviewing terminally ill people: is it fair to take their time? Palliat Med 2001; 15: 157-158.
46. Bradburn, J, Maher, J. User and carer participation in research in palliative care. Palliat Med 2005; 19: 91-92.
47. Daniels, LE, Exley, C. Preparation, information and liaison: conducting successful research in palliative care. Int J Palliat Nurs 2001; 7: 192-197.
48. Featherstone, K, Donovan, JL. Random allocation or allocation at random? Patients' perspectives of participation in a randomised controlled trial. BMJ 1998; 317: 1177-1180.
49. King, M. The effects of patients' and practitioners' preferences on randomized clinical trials. Palliat Med 2000; 14: 539-542.
50. Fletcher, RH, Fletcher, SW, Wagner, EH. Clinical Epidemiology. Baltimore, MD: Williams and Wilkins, 1992.
51. Fitzpatrick, R, Davey, C, Buxton, MJ, Jones, DR. Evaluating patient-based outcome measures for use in clinical trials. Health Technol Assess 1998; 2: i-74.
52. Korfage, IJ, Hak, T, de Koning, HJ, Essink-Bot, ML. Patients' perceptions of the side-effects of prostate cancer treatment-a qualitative interview study. Soc Sci Med 2006; 63: 911-919.
53. Nettleton, S. 'I just want permission to be ill': towards a sociology of medically unexplained symptoms. Soc Sci Med 2006; 62:1167-1178.
54. Meyer, G, Marjanovic, Z, Valcke, J, Lorcerie, B, Gruel, Y, Solal-Celigny, P, et al. Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med 2002; 162: 1729-1735.
55. Noble, SI, Finlay, IG. Is long-term low-molecular-weight heparin acceptable to palliative care patients in the treatment of cancer related venous thromboembolism? A qualitative study. Palliat Med 2005; 19: 197-201.
56. Ferrell, B, Wisdom, C, Wenzl, C, Brown, J. Effects of controlled-released morphine on quality of life for cancer pain. Oncol Nurs Forum 1989; 16: 521-526.
57. Bryman, A. Barriers to integrating quantitative and qualitative research. J Mixed Methods Res 2007; 1: 8-22.
58. Cox, K. Assessing the quality of life of patients in phase I and II anti-cancer drug trials: interviews versus questionnaires. Soc Sci Med 2003; 56: 921-934.
59. Onwuegbuzie, AJ, Teddlie, C. A framework for analyzing data in mixed methods research. In: Tashakkori, A, Teddlie, C, (eds). Handbook of Mixed Methods in Social and Behavioral Research. Thousand Oaks, CA: Sage, 2003.