Selective decline of the metabolic competence of oversized synaptic mitochondria in the old monkey cerebellum

Rejuvenation Research

Volumn 11, Issue 2, 2008, Pages 387-391

  Bertoni Freddari, Carlo ^a   Balietti, Marta ^a   Giorgetti, Belinda ^a   Grossi, Yessica ^a   Casoli, Tiziana ^a   Di Stefano, Giuseppina ^a   Perretta, Gemma ^b   Fattoretti, Patrizia ^a  

^a INRCA   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE;

ANIMAL EXPERIMENT; ARTICLE; CELL COMMUNICATION; CEREBELLUM; CONTROLLED STUDY; CYTOCHEMISTRY; ENZYME ACTIVITY; MACACA; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SYNAPSE;

AGING; ANIMALS; CEREBELLUM; ELECTRON TRANSPORT COMPLEX IV; HAPLORHINI; MITOCHONDRIA; MITOCHONDRIAL SIZE; SYNAPSES;

ANIMALIA; MACACA FASCICULARIS;

EID: 42649101666     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2008.0659     Document Type: Article

References (21)

1. Bertoni-Freddari C, Fattoretti P, Casoli T, et al. Neurobiology of the aging brain. In: Conn PM (ed.): Handbook of Models for the Study of Human Aging. San Diego: Elsevier, 2006, pp. 485-506.
2. Meier-Ruge W, Bertoni-Freddari C. Mitochondrial genome lesions in the pathogenesis of sporadic Alzheimer's disease. Gerontology 1999;45:289-297.
3. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Role of mitochondrial deterioration in physiological and pathological brain aging. Gerontology 2004;50:187-192.
4. Bertoni-Freddari C, Fattoretti P, Casoli T, et al. Morphological plasticity of synaptic mitochondria during aging. Brain Res 1993;628:193-200.
5. Wong-Riley MTT. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Nerosci 1989;12:94-101.
6. Bertoni-Freddari C, Fattoretti P, Casoli T, et al. Quantitative cytochemical mapping of mitochondrial enzymes in rat cerebella. Micron 2001;32:405-410.
7. Bertoni-Freddari C, Fattoretti P, Paoloni R, et al. Inverse correlation between mitochondrial size and metabolic competence: a quantitative cytochemical study of cytochrome oxidase activity. Naturwissenschaften 2003;90:68-71.
8. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Age-related decline in metabolic competence of small and medium-sized synaptic mitochondria. Naturwissenschaften 2005;92:82-85.
9. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Cytochemical estimation of cytochrome oxidase activity as a morphofunctional mitochondrial check-up. Rejuvenation Res 2006;9:202-206.
10. Coggesshall RE, Lekan HA. Methods for determining number of cells and synapses: a case for more uniform standard review. J Comp Neurol 1996;364:6-15.
11. Hof PR, Gilisse EP, Sherwood CC, et al. Comparative neuropathology of brain aging in primates. In: Erwin JM, Hof PR (eds.): Aging in Nonhuman Primates. Basel: Karger, 2002, pp. 130-154.
12. Joachim CL, Mori H, Selkoe DJ. Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease. Nature 1989;341:226-230.
13. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Synaptic pathology in the brain cortex of old monkeys as an early alteration in senile plaque formation. Rejuvenation Res 2006;9:85-88.
14. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. Ann NY Acad Sci 2007; 1096:128-137.
15. Bertoni-Freddari C, Fattoretti P, Giorgetti B, et al. Synaptic and mitochondrial morphometry provides structural correlates of successful brain aging. Ann NY Acad Sci 2007;1097:51-53.
16. Bereiter-Hahn J, Voth M. Dynamics of mitochondria in living cells: shape changes, dislocation, fusion and fission of mitochondria. Microsc Res Tech 1994;27:198-219.
17. Linnane AW, Marzuki S, Ozawa T, et al. Mitochondrial DNA mutations as an important contribution to aging and neurodegenerative diseases. Lancet 1989;642-645.
18. Toescu EC, Myronova N, Verkhratsky A. Age-related structural and functional changes of brain mitochondria. Cell Calcium 2000;28:329-338.
19. Walter PB, Beckman KB, Ames BN. The role of mitochondria and iron in aging. In: Cadenas E, and Packer L (eds.): Understanding the Process of Aging. The Role of Free Radicals and Antioxidants. New York: Dekker, 1999, pp. 203-227.
20. Solmi R, Pallotti F, Rugolo M. Lack of major mitochondrial bioenergetic changes in cultured skin fibroblasts from aged individuals. Biochem Mol Biol Int 1994;33:477-484.
21. Karbowsky M, Kurono C, Nishizawa, et al. Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocytes. Biochem Biophys Acta 1997;1349:242-250.