Cytochemical estimation of cytochrome oxidase activity as a morphofunctional mitochondrial check-up

Rejuvenation Research

Volumn 9, Issue 2, 2006, Pages 202-206

  Bertoni Freddari, Carlo ^a   Fattoretti, Patrizia ^a   Giorgetti, Belinda ^a   Grossi, Yessica ^a   Casoli, Tiziana ^a   Di Stefano, Giuseppina ^a   Balietti, Marta ^a  

^a INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; CYTOCHEMICAL PRECIPITATE MITOCHONDRIAL AREA RATIO; CYTOCHEMISTRY; ENERGY YIELD; ENZYME ACTIVITY; MEASUREMENT; MITOCHONDRION; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; TECHNIQUE; ULTRASTRUCTURE;

AGING; ANIMALS; ELECTRON TRANSPORT COMPLEX IV; IMMUNOHISTOCHEMISTRY; MITOCHONDRIA; RATS;

EID: 33744953978     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2006.9.202     Document Type: Conference Paper

References (20)

1. Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Meier-Ruge W, Ulrich J. Morphological plasticity of synaptic mitochondria during aging. Brain Res 1993;628:193-200.
2. Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurol Sci 1993;16:125-131.
3. Luft R. The development of mitochondrial medicine. Proc Natl Acad Sci USA 1994;91:8731-8748.
4. Beal MF. Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurol Sci 2000;23:298-304.
5. Singh K, Luccy BM, Zullo SJ. Mitochondria, oxidative stress and mitochondrial diseases. In: RG Cutler, H Rodriguez, eds. Critical Reviews of Oxidative Stress and Aging. Advances in Basic Science, Diagnostics and Intervention. Singapore: World Scientific, 2003:452-466.
6. Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992;256:628-632.
7. Bertoni-Freddari C, Fattoretti P, Giorgetti B, Solazzi M, Balietti M, Meier-Ruge. Role of mitochondrial deterioration in physiological and pathological brain aging. Gerontology 2004;50:187-192.
8. Bertoni-Freddari C, Fattoretti P, Casoli T, Di Stefano G, Solazzi M, Meier-Ruge W. Quantitative cytochemical mapping of mitochondrial enzymes in rat cerebella. Micron 2001;32:405-410.
9. Bertoni-Freddari C, Fattoretti P, Paoloni R, Caselli U, Giorgetti B, Solazzi M. Inverse correlation between mitochondrial size and metabolic competence: a quantitative cytochemical study of cytochrome oxidase activity. Naturwissenschaften 2003;90:68-71.
10. Bertoni-Freddari C, Fattoretti P, Giorgetti B, Spazzafumo L, Solazzi M, Balietti M. Age-related decline in metabolic competence of small and medium-sized synaptic mitochondria. Naturwissenschaften 2005;92:82-85.
11. Seligman AM, Karnowsky MJ, Wasserkrug HL, Hanker JS. Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerising osmiophilic reagent, diaminobenzidine (DAB). J Cell Biol 1968;38:1-14.
12. Wong-Riley MTT. Changes in the visual system of monocular sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. Brain Res 1979;171:11-28.
13. Coggeshall RE, Lekan HA. Methods for determining number of cells and synapses: a case for more uniform standard review. J Comp Neurol 1996;364:6-15.
14. Collins TJ, Berridge MJ, Lipp P, Bootman MD. Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J 2002;21:1616-1627.
15. Hanson BJ, Carrozzo R, Piemonte F, Tessa A, Robinson BH, Capaldi RA. Cytochrome c oxidase-deficient patients have distinct subunits assembly profiles. J Biol Chem 2001;276:16296-16301.
16. Taaman JW. Human cytochrome c oxidase: structure, function, and deficiency. J Bioenerg Biomembr 1997;29:151-163.
17. Toescu EC, Myronova N, Verkhratsky A. Age-related structural and functional changes of brain mitochondria. Cell Calcium 2000;28:329-338.
18. Dykens JA, Carroll AK, Wright AC, Fleck B. Mitochondrial dysfunction in aging and disease: development of therapeutic strategies. In: RG Cutler, H Rodriguez, eds. Critical Reviews of Oxidative Stress and Aging. Advances in Basic Science, Diagnostics and Intervention. Singapore: World Scientific, 2003:452-466.
19. Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to aging and degenerative diseases. Lancet 1989;642-645.
20. Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in aging. Lancet 1989;637-639.