Retinal safety of oral and topical ofloxacin in rabbits

Journal of Ocular Pharmacology and Therapeutics

Volumn 13, Issue 4, 1997, Pages 369-379

  Cohen, Robyn G ^a   Raizman, Michael ^a,b   Callina, Cynthia ^a   Lahav, Moshe ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW ENGLAND EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OFLOXACIN;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG PENETRATION; DRUG SAFETY; EYE INFECTION; EYE TOXICITY; INTRAOCULAR PRESSURE; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; TOPICAL DRUG ADMINISTRATION;

EID: 0030766485     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1997.13.369     Document Type: Article

References (11)

1. Monk, J.P. and Campoli-Richards, D.M. Ofloxacin: A review of its antibacterial activity pharmacokinetic properties, and therapeutic use. Drugs, 33:346, 1987.
2. Von Gunten, S., Lew, D., Paccolat, F., Vaudaux, P., Brazitikos, P.D., and Leuenberger, P.M. Aqueous humor penetration of ofloxacin given by various routes. Am. J. Ophthalmol., 117:87-89, 1994.
3. Donnenfeld, E.D., Schier, A., Perry, H.D., Aulicino, T., Gombert, M.E., and Snyder, R. Penetration of topically applied ciprofloxacin, norfloxacin, and ofloxacin into the aqueous humor. Ophthalmology, 101:902-905, 1994.
4. Gwon, A. Ofloxacin vs. tobramycin for the treatment of external ocular infection. Arch. Ophthalmol., 110:1234-1237, 1992.
5. Osato, M.S., Jensen, H.G., Trousdale, M.D., et al. The comparative in vitro activity of ofloxacin and selected ophthalmic antimicrobial agents against ocular bacterial isolates. Am. J. Ophthalmol., 108:380-386, 1989.
6. Mitsui, Y., Sakuragi, S., Tamura, O., et al. Effect of ofloxacin ophthalmic solution in the treatment of external bacterial infections of the eye. Folina Ophthalmol., 37:1115-1140, 1986.
7. Sasovetz, D. Ketamine hydrochloride: an effective general anesthetic for use in electroretinography. Ann. Ophthalmol., 10:1510-1514, 1978.
8. Lode, H., Hoffken, G., and Prinzing, C. Comparative pharmacokinetics of new quinolones. Drugs, 34(Suppl. 1):21-25, 1987.
9. Kresken, M. and Wiedermann, B. Development of resistance to nalidixic acid and the fluoroquinolones after the introduction of norfloxacin and ofloxacin. Antimicrob. Agents Chemother., 32:1285-1288, 1988.
10. Mochizuki, K., Torisaki, M., and Wakabayashi, K. Effects of vancomycin and ofloxacin on rabbit ERG in vivo. Jpn. J. Ophthalmol., 35:435-445, 1991.
11. Sable, M., DAversa, G. and Sorenson, J., et al. Retinal toxicity of sparfloxaxin, ofloxacin, and imipenem in a rabbit model. Invest. Ophthalmol. Vis. Sci. (suppl.), 37:5778, 1996.