Studies on the binding mechanism of fluoroquinolones to melanin

Journal of Infection and Chemotherapy

Volumn 6, Issue 2, 2000, Pages 72-76

  Fukuda, Masamichi ^a   Morita, Yasuo ^b   Sasaki, Kazuyuki ^a   Yamamoto, Yutaka ^b  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Binding mechanism; Melanin affinity Fluoroquinolones; Metal ions; Ocular melanin

Indexed keywords

5 HYDROXYTRYPTOPHAN; BARIUM ION; CALCIUM ION; CHLOROQUINE; CHLORPROMAZINE; CIPROFLOXACIN; COPPER ION; FUNCTIONAL GROUP; IRON; LEVODOPA; LEVOFLOXACIN; LITHIUM ION; LOMEFLOXACIN; MAGNESIUM ION; MELANIN; NICKEL; NORFLOXACIN; OFLOXACIN; PHENYLALANINE; POTASSIUM ION; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SODIUM ION; TRYPTOPHAN; TYROSINE;

ANTIBACTERIAL ACTIVITY; BACILLUS SUBTILIS; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; METAL BINDING; NONHUMAN; REVIEW;

EID: 0033911784     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00012154     Document Type: Article

References (21)

1. Barza M, Kane A, Baum J. Marked differences between pigmented and albino rabbits in the concentration of clindamycin in iris and choroid-retina. J Infect Dis 1979;139:203-8.
2. Potts AM. The reaction of uveal pigment in vitro with polycyclic compounds. Invest Ophthalmol Vis Sci 1964;3:405-16.
3. Barza M, Baum J, Kane A. Inhibition of antibiotic activity in vitro by synthetic melanin. Antimicrob Agents Chemother 1976;10:569-70.
4. Salazar M, Shimada K, Patil PN. Iris pigmentation and atropine mydriasis. J Pharmacol Exp Ther 1976;197:79-88.
5. Atlasik B, Stepien K, Wllczok T. Interaction of drugs with ocular melanin in vitro. Exp Eye Res 1980;30:325-31.
6. Lyons JS, Krohn DL. Pilocarpine uptake by pigmented uveal tissues. Am J Ophthalmol 1973;75:885-8.
7. Potts AM. The concentration of phenothiazines in the eye of experimental animals. Invest Ophthalmol Vis Sci 1962;1:522-30.
8. Fukuda M, Sasaki K. Intraocular dynamic mode differences of new quinolone antibacterial agents between pigmented and albino rabbit eyes. Lens Eye Toxic Res 1989;6:339-51.
9. Abrahamsson T, Bostrom S, Brautigam J, Lagerstrom PO, Regardh CG, Vauqelin G. Binding of the β-blockers timolol and H216/44 to ocular melanin. Exp Eye Res 1988;47:565-77.
10. Tjalve H, Nilsson M, Larsson B. Studies on the binding of chlorpromazine and chloroquine to melanin in vivo. Biochem Pharmacol 1981;30:1845-7.
11. Stepien KB, Wilczok T. Studies of the mechanism of chloroquine binding to synthetic dopa-melanin. Biochem Pharmacol 1982; 31:3359-65.
12. Ivanina TA, Sakina NL, Lebedeva MN, Borovjagin VL. A study of the mechanisms of chloroquine retinopathy. II. Chloroquine effect on protein synthesis of retina. Ophthalmic Res 1989;21:272-7.
13. Fukuda M, Sasaki K. Changes in the antibacterial activity of drugs. Ophthalmic Res 1990;22:1233-7.
14. Mitsui Y, Mita S. The xenobiotics of ofloxacin in the eyes of pigmented animals, with special reference to ocular safety. Atarashii Ganka (J Eye). 1993;10:83-6.
15. Fukuda M, Sasaki K. The influence of melanin on intraocular dynamics. Acta Soc Ophthalmol Jpn 1988;92:1839-43.
16. Mitsui Y, Ohkubo H, Komuro M. Intraocular pharmacokinetics of norfloxacin (NFLX) in pigmented animals. Chemotherapy 1995; 42:414-20.
17. Barza M, Brown B, Shen D, Gibaldi M, Weinstein L. Predictability of blood levels of gentamicin in man. J Infect Dis 1975;132:165-74.
18. Larsson B, Tjalve H. Studies on the mechanism of drug-binding to melanin. Biochem Pharmacol 1979;28:1181-7.
19. Tjalve H, Nilsson M, Larsson B. Studies on the binding of chlorpromazine and chloroquine to melanin in vivo. Biochem Pharmacol 1981;30:1845-7
20. Shiba K, Saito A, Miyahara T, Tachizawa H, Fujimoto T. Effect of aluminum hydroxide, an antacid, on the pharmacokinetics of new quinolones in humans. In: Proceedings of 15th International Congress of Chemotherapy, Astr Istanbul 1987;247.
21. Yano S, Kaisaki S, Sasaki Y, Yamaguchi M, et al. Complex chemistry. Tokyo: Kodansha; 1994. pp. 76-105.